Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 68, Issue 2, 2012, Pages 115-118

  Kirby, Christina A ^a   Cheung, Atwood ^a   Fazal, Aleem ^a   Shultz, Michael D ^a   Stams, Travis ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

displacement soaking; inhibitor complexes; PARP domains; tankyrase

Indexed keywords

ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; N (OXO 5,6 DIHYDROPHENANTHRIDIN 2 YL) N,N DIMETHYLACETAMIDE HYDROCHLORIDE; N-(OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE; PHENANTHRENE DERIVATIVE; TANKYRASE; TNKS PROTEIN, HUMAN; XAV939;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MODELS, MOLECULAR; PHENANTHRENES; PROTEIN INTERACTION DOMAINS AND MOTIFS; TANKYRASES;

EID: 84856890540     PISSN: None     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309111051219     Document Type: Article

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