Rare LEDGF/p75 genetic variants in white long-term nonprogressor HIV+ individuals

AIDS

Volumn 26, Issue 4, 2012, Pages 527-528

  Ballana, Ester ^a   Gonzalo, Encarna ^a   Grau, Eulàlia ^a   Iribarren, José A ^b   Clotet, Bonaventura ^a   Este, José A ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b HOSPITAL DONOSTIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75;

ALLELE; CD4 LYMPHOCYTE COUNT; CELL COUNT; CHROMOSOME; DISEASE COURSE; DISEASE DURATION; EXON; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LETTER; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION;

EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HIV INTEGRASE; HIV LONG-TERM SURVIVORS; HIV SEROPOSITIVITY; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS;

EID: 84856860485     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834fa194     Document Type: Letter

References (11)

1. Study IHC. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010; 330:1551-1557.
2. Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog 2009; 5:e1000437.
3. Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, et al. A whole-genome association study of major determinants for host control of HIV-1. Science 2007; 317:944-947. (Pubitemid 47301321)
4. Engelman A, Cherepanov P. The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog 2008; 4:e1000046.
5. Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, et al. A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 2005; 11:1287-1289. (Pubitemid 41752906)
6. Adamson CS, Freed EO. Novel approaches to inhibiting HIV-1 replication. Antiviral Res 2010; 85:119-141.
7. Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, et al. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol 2010; 6:442-448.
8. Madlala P, Gijsbers R, Christ F, Hombrouck A, Werner L, Mlisana K, et al. Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. AIDS 2011; 25:1711-1719.
9. Garcia-Merino I, de Las Cuevas N, Jimenez JL, Gallego J, Gomez C, Prieto C, et al. The Spanish HIV BioBank: a model of cooperative HIV research. Retrovirology 2009; 6:27.
10. Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, et al. ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression. Clin Infect Dis 2010; 50:1022-1032.
11. Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 2008; 40:695-701. (Pubitemid 351748875)