In situ Raman spectroscopy: A process analytical technology tool to monitor a de-protection reaction carried out in aqueous solution

Applied Spectroscopy

Volumn 66, Issue 2, 2012, Pages 151-156

  Clegg, Ian M ^a   Pearce, John ^b   Content, Sté Phane ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b Sandwich Laboratories   (United Kingdom)

Author keywords

Crizotinib; De protection; Fluorescence; PAT; Process analytical technology; Process development; Raman spectroscopy

Indexed keywords

CRIZOTINIB; DEPROTECTION; PAT; PROCESS ANALYTICAL TECHNOLOGY; PROCESS DEVELOPMENT;

FLUORESCENCE; RAMAN SPECTROSCOPY; REACTION INTERMEDIATES; SOLUTIONS;

RAMAN SCATTERING;

WATER;

ARTICLE; CHEMICAL REACTION; FLUORESCENCE; METHODOLOGY; PH; PHARMACEUTICS; RAMAN SPECTROMETRY; TEMPERATURE;

CHEMICAL PROCESSES; FLUORESCENCE; HYDROGEN-ION CONCENTRATION; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; WATER;

EID: 84856858326     PISSN: 00037028     EISSN: None     Source Type: Journal    
DOI: 10.1366/11-06355     Document Type: Article

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