Lipid A decreases human erythrocytes deformability by increasing intracellular Ca 2+: Effects of verapamil, staurosporine and the rho-kinase inhibitor Y-27632

Clinical Hemorheology and Microcirculation

Volumn 49, Issue 1-4, 2011, Pages 315-322

  Ruef, P ^a   Ehrhard, M ^a   Frommhold, D ^a   Koch, L ^a   Fritzsching, B ^a   Poeschl, J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Ca 2+; deformability; lipid A; Red blood cell; rho kinase inhibitor; sepsis; staurosporine; verapamil

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM ION; ENHANCED GREEN FLUORESCENT PROTEIN; LIPID A; STAUROSPORINE; VERAPAMIL;

CALCIUM CELL LEVEL; CELL ELONGATION; CLINICAL ARTICLE; CONFERENCE PAPER; DRUG EFFECT; ERYTHROCYTE DEFORMABILITY; ESCHERICHIA COLI; FLOW CYTOMETRY; HUMAN; MALE; MECHANICAL STRESS; SHEAR STRESS;

ADULT; AMIDES; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; DEPRESSION, CHEMICAL; DRUG INTERACTIONS; ERYTHROCYTE DEFORMABILITY; ESCHERICHIA COLI; HUMANS; LIPID A; MALE; PROTEIN KINASE INHIBITORS; PYRIDINES; RHO-ASSOCIATED KINASES; SHEAR STRENGTH; STAUROSPORINE; VERAPAMIL;

EID: 84856827815     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-2011-1482     Document Type: Conference Paper

References (26)

1. D.A. Andrews, L. Yang and P.S. Low, Phorbol ester stimulates a protein kinase C-mediated gatoxin-TK-sensitive calcium permeability pathway in human red blood cells, Blood 100 (2002), 3392-3399. (Pubitemid 35217092)
2. Anonymous, Ethical guidelines for publication in Clinical Hemorheology and Microcirculation, Clin Hemorheol Microcirc 44 (2010), 1-2.
3. O.K. Baskurt, M. Boynard, G.C. Cokelet, P. Connes, B.M. Cooke, S. Forconi, F. Liao, M.R. Hardeman, F. Jung, H.J. Meiselman, G. Nash, N. Nemeth, B. Neu, B. Sandhagen, S. Shin, G. Thurston and J.L. Wautier, International expert panel for standardization of hemorheological methods. New guidelines for hemorheological laboratory techniques, Clin Hemorheol Microcirc 42 (2009), 75-97.
4. O.K. Baskurt, D. Gelmont and H.J. Meiselman, Red blood cell deformability in sepsis, Am J Respir Crit Care Med 157 (1998), 421-427. (Pubitemid 28090530)
5. A.A. Boukharov and C.M. Cohen, Guanine nucleotide-dependent translocation of rho A from cytosol to high affinity membrane binding sites in human erythrocytes, Biochem J 330 (1998), 1391-1398. (Pubitemid 28162020)
6. P. Cabrales, Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia, Am J Physiol Heart Circ Physiol 293 (2007), H1206-H1215. (Pubitemid 47254223)
7. S. de Oliveira, A.S. Silva-Herdade and C. Saldanha, Modulation of erythrocyte deformability by PKC activity, Clin Hemorheol Microcirc 39 (2008), 363-373. (Pubitemid 352040016)
8. C.F. Fernandez, Red blood cell deformability is critical for oxygen utilization in sepsis, Crit Care Med 37 (2009), 3172-3173.
9. E. Friederichs and H.J. Meiselman, Effects of calcium permeabilization onRBCrheologic behavior, Biorheology 31 (1994), 207-215. (Pubitemid 24150326)
10. Y. Fukata, N. Oshiro, N. Kinoshita, Y. Kawano, Y. Matsuoka, V. Bennett, Y. Matsuura and K. Kaibuchi, Phosphorylation of adductin by rho-kinase plays a crucial role in cell motility, J Biol Chem 145 (1999), 347-361. (Pubitemid 29198306)
11. B.S. Hall, O.O. Daramola, G. Barden and G.A. Targett, Modulation of protein kinase C activity in Plasmodium falciparuminfected erythrocytes, Blood 89 (1997), 1770-1778. (Pubitemid 27097473)
12. A. Hitomi, S. Satoh, I. Ikegaki, Y. Suzuki, M. Shibuya and T. Asano, Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity, Life Sci 67 (2000), 1929-1939.
13. F. Jung, From hemorheology to microcirculation and regenerative medicine: F̊ahraeus Lecture 2009, Clin Hemorheol Microcirc 45 (2010), 79-99.
14. A. Marossy, P. Svorc, I. Kron and S. Gresov′a, Hemorheology and circulation, Clin Hemorheol Microcirc 42 (2009), 239-258.
15. C. Mehlin, C. Crittenden and J. Andreyka, No-wash dyes for calcium flux measurement, Biotechniques 34 (2003), 164-166. (Pubitemid 36070914)
16. G. Minetti and P.S. Low, Erythrocyte signal transduction pathways and their possible functions, Cur Opin Haematol 4 (1997), 116-121. (Pubitemid 27202127)
17. A.G. Moutzouri, A.T. Skoutelis, C.A. Gogos, Y.F. Missirlis and G.M. Athanassiou, Red blood cell deformability in patients with sepsis: A marker for prognosis and monitoring of severity, Clin Hemorheol Microcirc 36 (2007), 291-299. (Pubitemid 46868439)
18. M. Piagnerelli, K. Zouaoui Boudjeltia, M. Vanhaeverbeck and J.-L. Vincent, Red blood cell rheology in sepsis, Intensive Care Med 29 (2003), 1052-1061. (Pubitemid 36918545)
19. J.M.B. Poeschl, C. Leray, P. Ruef, J.P. Cazenave and O. Linderkamp, Endotoxin binding to erythrocyte membrane and erythrocyte deformbility in human sepsis and in vitro, Crit Care Med 31 (2003), 924-928. (Pubitemid 36379605)
20. G. Reggiori, G. Occhipinti, A. De Gasperi, J.-L. Vincent and M. Piagnerelli, Early alterations of red blood cell rheology in critically ill patients, Crit Care Med 37 (2009), 3041-3046.
21. 2+ increase in human platelets, Biochem J 278 (1991), 75-80.
22. A.O. Santos, E.S. Furtado, N.R.Villela and E. Bouskela, Microcirculatory effects of fluid therapy and dopamine, associated or not to fluid therapy, in endotoxemic hamsters, Clin Hemorheol Microcirc 47 (2011), 1-13.
23. H. Schmid-Scḧonbein, P. Ruef and O. Linderkamp, The shear stress diffractometer Rheodyn SSD for determination of erythrocyte deformability. I. Principles of operation and reproducibility, Clin Hemorheol 16 (1996), 745-748. (Pubitemid 26406190)
24. M. Sitina, Z. Turek, R. Parizkova, C. Lehmann and V. Cerny, Preserved cerebral microcirculation in early stages of endotoxemia in mechanically- ventilated rabbits, Clin Hemorheol Microcirc 47 (2011), 37-44.
25. J.C. Todd3rd and D.L. Mollitt, Effect of sepsis on erythrocyte intracellular calcium homeostasis, Crit Care Med 23 (1995), 459-465.
26. M.B. Yerer, H. Yapislar, S. Aydogan, O. Yalcin and O. Baskurt, Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin, Clin Hemorheol Microcirc 30 (2004), 77-82. (Pubitemid 38402420)