Solute clearance in CRRT: Prescribed dose versus actual delivered dose

Nephrology Dialysis Transplantation

Volumn 27, Issue 3, 2012, Pages 952-956

  Lyndon, William D ^a   Wille, Keith M ^b   Tolwani, Ashita J ^a  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Acute kidney injury; Continuous renal replacement therapy; Critical care nephrology; Dialysis dose

Indexed keywords

CREATININE; NITROGEN; UREA;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTINUOUS HEMODIAFILTRATION; CONTINUOUS RENAL REPLACEMENT THERAPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOSE CALCULATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; BLOOD UREA NITROGEN; CREATININE; CRITICAL ILLNESS; FEMALE; HEMODIAFILTRATION; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RENAL REPLACEMENT THERAPY; UREA;

EID: 84856817006     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr480     Document Type: Article

References (24)

1. Barrantes F, Tian J, Vazquez R et al. Acute kidney injury criteria predict outcomes of critically ill patients. Crit Care Med 2008; 36: 1397-1403
2. Liano F, Pascual J. Outcomes in acute renal failure. Semin Nephrol 1998; 18: 541-550
3. Uchino S, Kellum JA, Bellomo R et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294: 813-818
4. Prowle JR, Bellomo R. Continuous renal replacement therapy: recent advances and future research. Nat Rev Nephrol 2010; 6: 521-529
5. Bouchard J, Macedo E, Mehta R. Dosing of renal replacement therapy in acute kidney injury: lessons learned from clinical trials. Am J Kidney Dis 2010; 55: 570-579
6. Ronco C, Bellomo R, Homel P et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: A prospective randomized trial. Lancet 2000; 356: 26-30
7. Saudan P, Niederberger M, De Seigneux S et al. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure. Kidney Int 2006; 70: 1312-1317
8. Bouman C, Oudemans-van Straaten H, Tijssen J et al. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med 2002; 30: 2205-2211
9. Tolwani AJ, Campbell RC, Stofan BS et al. Standard versus highdose CVVHDF for ICU-related acute renal failure. J Am Soc Nephrol 2008; 19: 1233-1238
10. Palevsky PM, Zhang JH, O'Connor TZ et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 2008; 359: 7-20
11. Bellomo R, Cass A, Cole L et al. Intensity of continuous renalreplacement therapy in critically ill patients. N Engl J Med 2009; 361: 1627-1638
12. Vesconi S, Cruz DN, Fumagalli R et al. Devlivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury. Crit Care 2009; 13: R57
13. Venkataraman R, Kellum JA, Palevsky P. Dosing patterns for continuous renal replacement therapy at a large academic medical center in the United States. J Crit Care 2002; 17: 246-250
14. Clark WR, Turk JE, Kraus MA et al. Dose determinants in continuous renal replacement therapy. Artif Organs 2003; 27: 815-820
15. Palevsky PM. Intensity of continuous renal replacement therapy in acute kidney injury. Semin Dial 2009; 22: 151-154
16. Troyanov S, Cardinal J, Geadah D et al. Solute clearances during continuous venovenous haemofiltration at various ultrafiltration flow rates using Multiflow-100 and HF1000 filters. Nephrol Dial Transplant 2003; 18: 961-966
17. Liao Z, Zhang W, Hardy PA et al. Kinetic comparison of different acute dialysis therapies. Artif Organs 2003; 27: 802-807
18. Brunet S, Leblanc M, Geadah D et al. Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates. Am J Kidney Dis 1999; 34: 486-492
19. Marshall MR. Current status of dosing and quantification of acute renal replacement therapy. Part 1: Mechanisms and consequences of therapy under-delivery. Nephrology (Carlton) 2006; 11: 171-180
20. Langsdorf LJ, Zydney AL. Effect of blood contact on the transport properties of hemodialysis membrances: A two-layer membrane model. Blood Purif 1994; 12: 292-307
21. Morti SM, Zydney AL. Protein-membrane interactions during hemodialysis: effects of solute transport. ASAIO J 1998; 44: 319-326
22. Messer J, Mulcahy B, Fissell WH. Middle-molecule clearance in CRRT: In vitro convection, diffusion and dialyzer area. ASAIO J 2009; 55: 224-226
23. Hoffman CL, Fissell WH. Middle molecule clearance at 20 and 35 ml/kg/h in continuous venovenous hemodiafiltration. Blood Purif 2010; 29: 259-263
24. Claure-Del Granado R, Macedo E, Chertow G et al. Effluent volume in continuous renal replacement therapy overestimates the delivered dose of dialysis. Clin J Am Soc Nephrol 2011; 6: 467-475