Do women exhibit greater differences in established and novel risk factors between diabetes and non-diabetes than men? the British Regional Heart Study and British Women's Heart Health Study

Diabetologia

Volumn 55, Issue 1, 2012, Pages 80-87

  Wannamethee, S G ^a   Papacosta, O ^a   Lawlor, D A ^b   Whincup, P H ^c   Lowe, G D ^d   Ebrahim, S ^e   Sattar, N ^d  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Cardiovascular risk factors; Diabetes; Insulin resistance; Sex

Indexed keywords

BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; D DIMER; FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TISSUE PLASMINOGEN ACTIVATOR; TRIACYLGLYCEROL; VON WILLEBRAND FACTOR;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VISCOSITY; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

ADIPOSITY; AGED; BIOLOGICAL MARKERS; BLOOD COAGULATION FACTORS; CARDIOVASCULAR DISEASES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HEALTH SURVEYS; HUMANS; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SEX CHARACTERISTICS;

EID: 84856758245     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2284-4     Document Type: Article

References (31)

1. Huxley R, Barzi F, Woodward M (2006) Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 332:73-78
2. Lee WL, Cape D, Cheung AM, Zinman B (2000) Impact of diabetes on coronary artery disease in women and men. A metaanalysis of prospective studies. Diabetes Care 23:962-968
3. Juutilainen A, Kortelainen S, Lehto S, Ronnemaa T, Pyorala K, LaakasoM(2004) Gender difference in the impact of type 2 diabetes on coronary heart disease risk. Diabetes Care 27:2898-2904 (Pubitemid 39565056)
4. Barrett-Connor EL, Cohn BA, Wingard DL, Edelstein SL (1991) Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. JAMA 265:627-631
5. Natarajan S, Liao Y, Sinha D, Cao G, Lipsitz SR, McGee DL (2003) Sex differences in risk for coronary heart disease mortality associated with diabetes and established coronary heart disease. Arch Intern Med 163:1735-1740 (Pubitemid 36898963)
6. Becker A, Bos G, de Vegt F et al (2003) Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals. Eur Heart J 24:1406-1413
7. Juutilainen A, Pyorala K, Lehto S, Laakso M, Ronnema T (2005) Type 2 diabetes as a "coronary heart disease equivalent": an 18 year prospective population based study in Finnish subjects. Diabetes Care 28:2901-2907 (Pubitemid 43942922)
8. Wexler DJ, Nathan DM, Grant RW, Cagliero E, Meigs JB (2005) Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes Care 28:514-520 (Pubitemid 40315306)
9. Howard BV, Cowan LD, Go O, Welty TK, Robbins DC, Lee ET, Strong Heart Study Investigators (1998) Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. Diabetes Care 21:1258-1265 (Pubitemid 28365680)
10. Haffner SM, Miettenen H, Stern MP (1997) Prelatively more atherogenic coronary heart disease risk factors in prediabetic women than in prediabetic men. Diabetologia 40:711-717 (Pubitemid 27288118)
11. Williams K, Tchernof A, Hunt KJ, Wagenknecht LE, Haffner SM, Sniderman AD (2008) Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men. Diabetes 57:3289-3296
12. Siegel RD, Cupples A, Schaefer EJ, Wilson PWF (1996) Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham Offspring Study. Metabolism 45:1267-1271
13. Sattar N, Wannamethee SG, Forouhi NG (2008) Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities? Diabetologia 51:926-940
14. Steinberg HO, Paradisi G, Cronin J et al (2000) Type II diabetes abrogates sex differences in endothelial function in premenopausal women. Circulation 101:2040-2046 (Pubitemid 30233166)
15. Chan P (1995) Coagulation activation in type 2 diabetes mellitus: the higher coronary risk of female diabetic patients. Diabet Med 12:504-507
16. Donahue RP, Rejman K, Rafalson LB, Dmochowski J, Strange S, Trevisan M (2007) Sex differences in endothelial function markers before conversion to pre-diabetes: does the clock start ticking earlier among women: the Western New York study. Diabetes Care 30:354-359 (Pubitemid 46198343)
17. Mansfield MW, Heywood DM, Grant PJ (1996) Sex differences in coagulation and fibrinolysis in white subjects with non-insulin dependent diabetes mellitus. Artherioscler Thromb Vasc Biol 16:160-164 (Pubitemid 26026946)
18. Yudkin JS. Abnormalities of coagulation and fibrinolysis in insulin resistance. Evidence for a common antecedent. Diabetes Care 22 (Suppl 3):C25-C30
19. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH (2005) The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men. Atherosclerosis 181:101-108 (Pubitemid 40804699)
20. Regitz-Zagrosek V, Lehmkuhl E, Weickert MO (2006) Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol 95:136-147
21. Shaper AG, Pocock SJ, Walker M, Cohen NM, Wale CJ, Thomson AG (1981) British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns. BMJ 283:179-186 (Pubitemid 11071686)
22. Lawlor DA, Bedford C, Taylor M, Ebrahim S (2003) Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study. J Epidemiol Community Health 57:134-140 (Pubitemid 36160623)
23. Wannamethee SG, Whincup PH, Shaper AG, Rumley A, Lennon L, Lowe GDO (2009) Circulating inflammatory and haemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men. J Thromb Haemost 7:1605-1611
24. Emberson J, Whincup PH, Walker M, Thomas M, Alberti KGM (2002) Biochemical measures in a population based study: the effect of fasting duration and time of day. Ann Clin Biochem 39:493-501 (Pubitemid 34983445)
25. Wannamethee SG, Papacosta O, Whincup PH et al (2010) Assessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women. Diabetologia 53:890-898
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Preacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419 (Pubitemid 15018832)
27. Wannamethee SG, Lowe GDO, Shaper AG, Rumley A, Lennon L, Whincup PH (2004) Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in type 2 diabetes with and without coronary heart disease. Diabetologia 47:1557-1565 (Pubitemid 39371638)
28. Lipscombe LL, Hux JE (2007) Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: a population-based study. Lancet 369:750-756 (Pubitemid 46321630)
29. Saltevo J, Kautiainen H, Vanhala M (2009) Gender differences in adiponectin and low grade inflammation among individuals with normal glucose tolerance, prediabetes and type 2 diabetes. Gend Med 6:463-470
30. Nilsson G, Hedberg P, Jonason T, Lonnberg I, Tenerz A, Ohrvik J (2007) White blood cell counts associate more strongly to the metabolic syndrome in 75 year-old women than in men: a population based study. Metab Syndr Relat Disord 5:359-364 (Pubitemid 350208899)
31. Kleinman JC, Donahue RP, Harris MI, Finucane FF, Madans JH, Brock DB (1988) Mortality among diabetics in a national sample. Am J Epidemiol 128:389-401