CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst

Journal of Biotechnology

Volumn 157, Issue 3, 2012, Pages 405-412

  Kleser, Michael ^a   Hannemann, Frank ^a   Hutter, Michael ^a   Zapp, Josef ^a   Bernhardt, Rita ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

CYP105A1; Sulfonylurea; Whole cell biocatalyst

Indexed keywords

ACTIVE SITE; BACILLUS MEGATERIUM; COMPUTATIONAL DOCKINGS; CYP105A1; CYTOCHROMES P450; ELECTRON TRANSFER; FERREDOXIN REDUCTASE; FISSION YEAST; GLIBENCLAMIDE; GLIMEPIRIDE; HOST STRAIN; HYPOGLYCEMIC DRUG; IN-VITRO; NMR ANALYSIS; RECOMBINANT BACILLI; REDOX PARTNERS; SCHIZOSACCHAROMYCES POMBE; SULFONYLUREA; WHOLE CELL BIOCATALYSTS;

BACILLI; BACTERIOLOGY; BIOCATALYSTS; CYTOLOGY; ELECTRON TRANSITIONS; ENZYMES; METABOLISM;

HYDROXYLATION;

CYTOCHROME; CYTOCHROME P450 105A1; ENZYME; GLIBENCLAMIDE; GLIMEPIRIDE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS MEGATERIUM; BIOCATALYST; CONTROLLED STUDY; DRUG TRANSFORMATION; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; WHOLE CELL;

BACILLUS MEGATERIUM; BACTERIAL PROTEINS; BLOTTING, WESTERN; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FERREDOXIN-NADP REDUCTASE; FERREDOXINS; GLYBURIDE; HYDROXYLATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; OXYGENASES; PLASMIDS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SULFONYLUREA COMPOUNDS;

BACILLUS MEGATERIUM; PROKARYOTA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE; STREPTOMYCES GRISEOLUS;

EID: 84856753247     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.12.006     Document Type: Article

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