Association of HbA 1c levels with vascular complications and death in patients with type 2 diabetes: Evidence of glycaemic thresholds

Diabetologia

Volumn 55, Issue 3, 2012, Pages 636-643

  Zoungas, S ^a,b   Chalmers, J ^a   Ninomiya, T ^a   Li, Q ^a   Cooper, M E ^c   Colagiuri, S ^d   Fulcher, G ^e   De Galan, B E ^a,f   Harrap, S ^g   Hamet, P ^h   Heller, S ⁱ   MacMahon, S ^a   Marre, M ^j   Poulter, N ^k   Travert, F ^j   Patel, A ^a   Neal, B ^a   Woodward, M ^a,l  

^a GEORGE INSTITUTE FOR GLOBAL HEALTH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ROYAL NORTH SHORE HOSPITAL   (Australia)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

ⁱ UNIVERSITY OF SHEFFIELD   (United Kingdom)

^j BICHAT HOSPITAL   (France)

^k NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^l JOHNS HOPKINS UNIVERSITY   (United States)

more..

Author keywords

Glycaemic control; Macrovascular disease; Microvascular disease; Mortality; Type 2 diabetes

Indexed keywords

GLICLAZIDE; GLUCOSE; HEMOGLOBIN A1C; INDAPAMIDE PLUS PERINDOPRIL; PLACEBO; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HEART DEATH; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; MORTALITY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; VASCULAR DISEASE; BLOOD; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; DIABETIC ANGIOPATHY; DRUG COMBINATION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERTENSION; MICROVASCULATURE; MIDDLE AGED; PATHOLOGY; PROPORTIONAL HAZARDS MODEL;

AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; BLOOD GLUCOSE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; HYPERTENSION; HYPOGLYCEMIC AGENTS; MALE; MICROVESSELS; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84856751751     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2404-1     Document Type: Article

References (19)

1. M Coutinho HC Gerstein Y Wang S Yusuf 1999 The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years Diabetes Care 22 233 240 10333939 10.2337/diacare.22.2.233 1:STN:280: DyaK1M3ms1Crsw%3D%3D
2. KT Khaw N Wareham S Bingham R Luben A Welch N Day 2004 Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk Ann Intern Med 141 413 420 15381514 1:CAS:528:DC%2BD2cXos1Cjtrg%3D
3. E Selvin S Marinopoulos G Berkenblit, et al. 2004 Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus Ann Intern Med 141 421 431 15381515 1:CAS:528:DC%2BD2cXos1Cjtrk%3D
4. IM Stratton AI Adler HA Neil, et al. 2000 Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study BMJ 321 405 412 10938048 10.1136/bmj.321.7258. 405 1:STN:280:DC%2BD3cvisFWnsg%3D%3D
5. S Gudbjörnsdottir B Eliasson K Eeg-Olofsson B Zethelius J Cederholm on behalf of the National Diabetes Register (NDR) 2011 Additive effects of glycaemia and dyslipidaemia on risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish National Diabetes Register Diabetologia 54 10 2544 2551 21674176 10.1007/s00125-011-2218-1
6. Emerging Risk Factors Collaboration 2010 Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies Lancet 375 2215 2222 10.1016/S0140-6736(10)60484-9
7. CJ Currie JR Peters A Tynan, et al. 2010 Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study Lancet 375 481 489 20110121 10.1016/S0140-6736(09)61969-3 1:CAS:528:DC%2BC3cXhs1altLs%3D
8. E Selvin MW Steffes H Zhu, et al. 2010 Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic patients N Engl J Med 362 800 811 20200384 10.1056/NEJMoa0908359 1:CAS:528:DC%2BC3cXivV2hu7Y%3D
9. W Duckworth C Abraira T Moritz, et al. 2009 Glucose control and vascular complications in veterans with type 2 diabetes N Engl J Med 360 129 139 19092145 10.1056/NEJMoa0808431 1:CAS:528:DC%2BD1MXnsFWkug%3D%3D
10. HC Gerstein ME Miller RP Byington, et al. 2008 Effects of intensive glucose lowering in type 2 diabetes N Engl J Med 358 2545 2559 18539917 10.1056/NEJMoa0802743 1:CAS:528:DC%2BD1cXnt1Wjs7s%3D
11. A Patel S MacMahon J Chalmers, et al. 2008 Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes N Engl J Med 358 2560 2572 18539916 10.1056/NEJMicm066227 1:CAS:528:DC%2BD1cXnt1yht7s%3D
12. FM Turnbull C Abraira RJ Anderson, et al. 2009 Intensive glucose control and macrovascular outcomes in type 2 diabetes Diabetologia 52 2288 2298 19655124 10.1007/s00125-009-1470-0 1:CAS:528:DC%2BD1MXht1Cis7jI Erratum 52: 2470
13. ADVANCE Management, Committee 2001 Study rationale and design of ADVANCE: action in diabetes and vascular disease-preterax and diamicron MR controlled evaluation Diabetologia 44 1118 1120 10.1007/s001250100612
14. Wales External Quality Assurance Scheme home page. www.weqas.com. Accessed 19 May 2008
15. DF Easton J Peto AG Babiker 1991 Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group Stat Med 10 1025 1035 1652152 10.1002/sim.4780100703 1:STN:280:DyaK3Mzktlymsg%3D%3D
16. WS Cleveland 1979 Robust locally weighted regression and smoothing scatterplots J Am Stat Assoc 74 829 836 10.2307/2286407
17. N Molinari JP Daures JF Durand 2001 Regression splines for threshold selection in survival data analysis Stat Med 20 237 247 11169599 10.1002/1097-0258(20010130)20:2<237::AID-SIM654>3.0.CO;2-I 1:STN:280:DC%2BD3M3gtlCktA%3D%3D
18. AC Dale K Midthjell TI Nilsen R Wiseth LJ Vatten 2009 Glycaemic control in newly diagnosed diabetes patients and mortality from ischaemic heart disease: 20-year follow-up of the HUNT Study in Norway Eur Heart J 30 1372 1377 19233856 10.1093/eurheartj/ehp039
19. AP Kengne A Patel S Colagiuri, et al. 2010 The Framingham and UKPDS risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: the ADVANCE Study Diabetologia 53 5 821 831 20157695 10.1007/s00125-010-1681-4 1:STN:280:DC%2BC3c3ksVyrtw%3D%3D