Effects of Clostridium perfringens alpha and epsilon toxins in the bovine gut

Anaerobe

Volumn 18, Issue 1, 2012, Pages 143-147

  Morris, Winston E ^a   Dunleavy, Mariana V ^a   Diodati, Julián ^a   Berra, Guillermo ^a   Fernandez Miyakawa, Mariano E ^a  

^a INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

Author keywords

Bovine; Calves; Clostridium perfringens; Intestinal loop; Toxin

Indexed keywords

CLOSTRIDIUM PERFRINGEN ALPHA TOXIN; CLOSTRIDIUM PERFRINGEN EPSILON TOXIN; CLOSTRIDIUM TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALF (BOVINE); CELL DEATH; COLON; CONTROLLED STUDY; DISEASE SEVERITY; EPITHELIUM CELL; ILEUM; INTERCELLULAR SPACE; INTESTINAL BLEEDING; INTESTINE; INTESTINE CELL; INTESTINE FLUID; INTESTINE LOOP; LAMINA PROPRIA; LAPAROTOMY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BACTERIAL TOXINS; CALCIUM-BINDING PROTEINS; CATTLE; CLOSTRIDIUM PERFRINGENS; ENTEROCYTES; INTESTINAL MUCOSA; INTESTINES; TYPE C PHOSPHOLIPASES;

BOVINAE; CAPRA HIRCUS; CLOSTRIDIUM PERFRINGENS; OVIS ARIES;

EID: 84856737427     PISSN: 10759964     EISSN: 10958274     Source Type: Journal    
DOI: 10.1016/j.anaerobe.2011.12.003     Document Type: Article

References (25)

1. Mantis N. Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin. Advanced Drug Delivery Reviews 2005, 57:1424-1439.
2. McClane B.A., Uzal F.A., Fernández Miyakawa M., Lyerly D., Wilkins T. The Enterotoxic Clostridia. The Prokaryotes 2006, vol. 4:698-752. Springer-Verlag, New York. M. Dworkin, S. Falkow, E. Rosenburg, K.H. Schleifer, E. Stackebrandt (Eds.).
3. Ceci L., Paradies P., Sasanelli M., de Caprariis D., Guarda F., Capucchio M.T., et al. Haemorrhagic bowel syndrome in dairy cattle: possible role of Clostridium perfringens type A in the disease complex. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine 2006, 53:518-523. (Erratum in: Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine. 54: 55, 2007).
4. Keyburn A.L., Boyce J.D., Vaz P., Bannam T.L., Ford M.E., Parker D., et al. NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathology 2008, 8(4):e26.
5. Manteca C., Daube G., Jauniaux T., Linden A., Pirson V., Detilleux J., et al. Arole for the Clostridium perfringens beta2 toxin in bovine enterotoxaemia?. Veterinary Microbiology 2002, 86:191-202.
6. Minami J., Katayama S., Matsushita O., Matsushita C., Okabe A. Lambda-toxin of Clostridium perfringens activates the precursor of epsilon-toxin by releasing its N- and C-terminal peptides. Microbiol Immunology 1997, 41:527-535.
7. Uzal F.A., Songer J.G. Diagnosis of Clostridium perfringens intestinal infections in sheep and goats. Journal Veterinary Diagnostic Investigations 2008, 20:253-265.
8. Finnie J.W. Pathogenesis of brain damage produced in sheep by Clostridium perfringens type D epsilon toxin: a review. Australian Veterinary Journal 2003, 81:219-221.
9. Titball R.W. Bacterial Phospholipases C.Microbiological. Reviews 1993, 57:347-366.
10. Brown C.C., Baker D.C., Barker I.K. Alimentary system. The Jubb, Kennedy and Palmer's pathology of Domestic animals 2007, 1-296. Sounders Elsevier. 5th ed. M. Grant Maxie (Ed.).
11. Miyata S., Matsushita O., Minami J., Katayama S., Shimamoto S., Okabe A. Cleavage of a C-terminal peptide is essential for heptamerization of Clostridium perfringens epsilon-toxin in the synaptosomal membrane. Journal of Biological Chemistry 2001, 276:13778-13783.
12. Losada-Eaton D.M., Uzal F.A., Fernández Miyakawa M.E. Clostridium perfringens epsilon toxin is absorbed from different intestinal segments of mice. Toxicon 2008, 51:1207-1213.
13. Niilo L., Avery R.J. Bovine "Enterotoxemia" I. Clostridium perfringens types isolated from animal Sources in Alberta and Saskatchewan. Canadian Veterinary Journal 1963, 4:31-36.
14. Niilo L. Clostridium perfringens in animal disease: a review of current knowledge. Canadian Veterinary Journal 1980, 21:141-148.
15. Uzal F.A., Ghoddusi M., Kelly W.R., Rozmanec M. Comparison of the effects of Clostridium perfringens type D culture supernates in ligated intestinal loops of goats and sheep. Journal Comparative Pathology 1999, 121:127-138.
16. Filho E.J., Carvalho A.U., Assis R.A., Lobato F.F., Rachid M.A., Carvalho A.A., et al. clinicopathological features of experimental Clostridium perfringens type D enterotoxemia in cattle. Veterinary Pathology 2009, 46:1213-1220.
17. Uzal F.A., Kelly W.R., Morris W.E., Assis R.A. Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves. Journal Comparative Pathology 2002, 126:71-75.
18. Fernandez Miyakawa M.E., Uzal F.A. Morphologic and physiologic changes induced by Clostridium perfringens type A alpha toxin in the intestine of sheep. American Journal of Veterinary Research 2005, 66:251-255.
19. Stern M., Batty I. Pathogenic Clostridia 1975, Butterworths, London, pp. 96-101.
20. Fernandez-Miyakawa M.E., Jost B.H., Billington S.J., Uzal F.A. Lethal effects of Clostridium perfringens epsilon toxin are potentiated by alpha and perfringolysin-O toxins in a mouse model. Veterinary Microbiology 2008, 127:379-385.
21. Sayeed S., Fernandez-Miyakawa M.E., Fisherm D.J., Adams V., Poon R., Rood J.I., et al. Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model. Infection and Immunity 2005, 73:7413-7421.
22. Uzal F.A., Kelly W.R. Experimental Clostridium perfringens type D enterotoxemia in goats. Veterinary Pathology 1998, 35:132-140.
23. Manteca C., Daube G., Pirson V., Limbourg B., Kaeckenbeeck A., Mainil J.G. Bacterial intestinal flora associated with enterotoxaemia in Belgian Blue calves. Veterinary Microbiology 2001, 81:21-32.
24. Fernandez Miyakawa M.E., Uzal F.A. The early effects of Clostridium perfringens type D epsilon toxin in ligated intestinal loops of goats and sheep. Veterinary Research Communications 2003, 27:231-241.
25. Goldstein J., Morris W.E., Loidl C.F., Tironi-Farinatti C., McClane B.A., Uzal F.A., et al. Clostridium perfringens epsilon toxin increases the small intestinal permeability in mice and rats. PLoS One 2009, 4:e7065.