Outcomes after escalation of infliximab therapy in ambulatory patients with moderately active ulcerative colitis

Alimentary Pharmacology and Therapeutics

Volumn 35, Issue 5, 2012, Pages 562-567

  Rostholder, E ^a   Ahmed, A ^a   Cheifetz, A S ^a   Moss, A C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; INFLIXIMAB; MERCAPTOPURINE; PREDNISONE;

ADULT; AMBULATORY CARE; ARTICLE; COLON RESECTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FEMALE; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; REMISSION; RETROSPECTIVE STUDY; TREATMENT DURATION; ULCERATIVE COLITIS; UNSPECIFIED SIDE EFFECT;

ADULT; AMBULATORY CARE; ANTIBODIES, MONOCLONAL; COHORT STUDIES; COLITIS, ULCERATIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL AGENTS; HUMANS; MALE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84856730490     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2011.04986.x     Document Type: Article

References (28)

1. Moss AC, Peppercorn MA,. Steroid-refractory severe ulcerative colitis: what are the available treatment options? Drugs 2008; 68: 1157-67. (Pubitemid 351822109)
2. Gies N, Kroeker KI, Wong K, Fedorak RN,. Treatment of ulcerative colitis with adalimumab or infliximab: long-term follow-up of a single-centre cohort. Aliment Pharmacol Ther 2010; 32: 522-8.
3. Gisbert JP, Gonzalez-Lama Y, Mate J,. Systematic review: infliximab therapy in ulcerative colitis. Aliment Pharmacol Ther 2007; 25: 19-37. (Pubitemid 44902861)
4. Oussalah A, Evesque L, Laharie D, et al,. A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalization. Am J Gastroenterol 2010; 105: 2617-25.
5. Rutgeerts P, Sandborn WJ, Feagan BG, et al,. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-76. (Pubitemid 41770166)
6. Sandborn WJ, Rutgeerts P, Feagan BG, et al,. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 2009; 137: 1250-60.
7. Zabana Y, Domenech E, Manosa M, et al,. Infliximab safety profile and long-term applicability in inflammatory bowel disease: 9-year experience in clinical practice. Aliment Pharmacol Ther 2010; 31: 553-60.
8. Danese S, Fiorino G, Reinisch W,. Review article: Causative factors and the clinical management of patients with Crohn's disease who lose response to anti-TNF-alpha therapy. Aliment Pharmacol Ther 2011; 34: 1-10.
9. Chaparro M, Martinez-Montiel P, Van Domselaar M,. Intensification of infliximab (IFX) therapy in Crohn's disease: efficacy and safety. Gastroenterology 2008; 134: A664.
10. Kaplan GG, Hur C, Korzenik J, Sands BE,. Infliximab dose escalation vs. initiation of adalimumab for loss of response in Crohn's disease: a cost-effectiveness analysis. Aliment Pharmacol Ther 2007; 26: 1509-20. (Pubitemid 350178810)
11. Seow CH, Newman A, Irwin SP, Steinhart AH, Silverberg MS, Greenberg GR,. Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Gut 2010; 59: 49-54.
12. Lawlor G, Moss AC,. Cause for controversy? Infliximab in the treatment of ulcerative colitis: an update. Clin Exp Gastroenterol 2009; 2: 149-61.
13. Panccione R, Ghosh S, Middleton S, et al,. Infliximab, azathioprine, or infliximab plus azathioprine for treatment of moderate to severe ulcerative colitis: the UC success trial. Gastroenterology 2011; 140: S134.
14. Lichtenstein GR, Diamond RH, Wagner CL, et al,. Clinical trial: benefits and risks of immunomodulators and maintenance infliximab for IBD-subgroup analyses across four randomized trials. Aliment Pharmacol Ther 2009; 30: 210-26.
15. Moss AC, Kim KJ, Fernandez-Becker N, Cury D, Cheifetz AS,. Impact of concomitant immunomodulator use on long-term outcomes in patients receiving scheduled maintenance infliximab. Dig Dis Sci 2010; 55: 1413-20.
16. Mowat C, Cole A, Windsor A, et al,. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011; 60: 571-607.
17. Mortensen C, Caspersen S, Christensen NL, et al,. Treatment of acute ulcerative colitis with infliximab, a retrospective study from three Danish hospitals. J Crohns Colitis 2011; 5: 28-33.
18. Reinisch W, Sandborn WJ, Rutgeerts P, et al,. Long-term infliximab maintenance therapy for ulcerative colitis: the ACT-1 and -2 extension studies. Inflamm Bowel Dis 2011 [Epub ahead of print].
19. Waters H, Vanderpoel J, McKenzie S, et al,. Stability of infliximab dosing in inflammatory bowel disease: results from a multicenter US chart review. J Med Econ 2011; 14: 397-402.
20. Jarnerot G, Hertervig E, Friis-Liby I, et al,. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology 2005; 128: 1805-11. (Pubitemid 40824691)
21. Filippi J, Allen PB, Hebuterne X, Peyrin-Biroulet L,. Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review. Curr Drug Targets 2011; 12: 1440-7.
22. Gisbert JP, Panes J,. Loss of response and requirement of infliximab dose intensification in Crohn's disease: a review. Am J Gastroenterol 2009; 104: 760-7.
23. Kopylov U, Mantzaris GJ, Katsanos KH, et al,. The efficacy of shortening the dosing interval to once every six weeks in Crohn's patients losing response to maintenance dose of infliximab. Aliment Pharmacol Ther 2011; 33: 349-57.
24. Regueiro M, Siemanowski B, Kip KE, Plevy S,. Infliximab dose intensification in Crohn's disease. Inflamm Bowel Dis 2007; 13: 1093-9. (Pubitemid 47402592)
25. Xie F, Blackhouse G, Assasi N, Gaebel K, Robertson D, Goeree R,. Cost-utility analysis of infliximab and adalimumab for refractory ulcerative colitis. Cost Eff Resour Alloc 2009; 7: 20.
26. Farmer RG, Easley KA, Rankin GB,. Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients. Dig Dis Sci 1993; 38: 1137-46. (Pubitemid 23175139)
27. Sokol H, Seksik P, Carrat F, et al,. Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapy. Gut 2010; 59: 1363-8.
28. Melmed GY, Spiegel BM, Bressler B, et al,. The appropriateness of concomitant immunomodulators with anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all. Clin Gastroenterol Hepatol 2010; 8: 655-9.