Nebulized 0.5, 2.5 and 5 ml l-epinephrine for post-extubation stridor in children: A prospective, randomized, double-blind clinical trial

Intensive Care Medicine

Volumn 38, Issue 2, 2012, Pages 286-293

  Da Silva, Paulo Sérgio Lucas ^a   Fonseca, Marcelo Cunio MacHado ^b   Iglesias, Simone Brasil Oliveira ^b   Junior, Emílio Lopes ^b   De Aguiar, Vânia Euzébio ^a   De Carvalho, Werther Brunow ^c  

^a HOSPITAL DO SERVIDOR PÚBLICO ESTADUAL DE SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Croup; Epinephrine; Extubation; Intensive care; Intubation; Stridor

Indexed keywords

ADRENALIN;

ARTICLE; ARTIFICIAL VENTILATION; CHILD; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EXTUBATION; FEMALE; HEART ARRHYTHMIA; HEART RATE; HEMODYNAMIC PARAMETERS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NEBULIZATION; PALLOR; POSTEXTUBATION STRIDOR; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REBOUND; RESPIRATORY TRACT PARAMETERS; SCORING SYSTEM; SIDE EFFECT; STRIDOR; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; TREATMENT OUTCOME; TREMOR; VITAL SIGN; WESTLEY SCORE;

AIRWAY EXTUBATION; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; EPINEPHRINE; FEMALE; HUMANS; INFANT; MALE; NEBULIZERS AND VAPORIZERS; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS;

EID: 84856725340     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-011-2408-9     Document Type: Article

References (28)

1. Anesthesia Study Committee of the New York State Society of Anesthesiologists 1972 Racemic epinephrine in postintubation laryngeal edema N Y State J Med 72 583 584
2. C Bjornson KF Russell B Vandermeer T Durec TP Klassen DW Johnson 2011 Nebulized epinephrine for croup in children Cochrane Database Syst Rev 2 CD006619 21328284
3. J Nutman LJ Brooks KM Deakins KK Baldesare MK Witte MD Reed 1994 Racemic versus l-epinephrine aerosol in the treatment of postextubation laryngeal edema: results from a prospective, randomized, double-blind study Crit Care Med 22 1591 1594 7924370 1:STN:280:DyaK2M%2FgvVynuw%3D%3D (Pubitemid 24320882)
4. A Sinha M Jayashree S Singhi 2010 Aerosolized l epinephrine versus budesonide for postextubation stridor: a randomized controlled trial Indian Pediatr 47 317 322 19736368 10.1007/s13312-010-0060-z 1:STN:280: DC%2BC3c3pslOhsQ%3D%3D
5. RG Cesar WB de Carvalho 2009 l-epinephrine and dexamethasone in postextubation airway obstruction: a prospective, randomized, double-blind placebo-controlled study Int J Pediatr Otorhinolaryngol 73 1639 1643 19762088 10.1016/j.ijporl.2009.08.004
6. A Preutthipan P Poomthavorn A Sumanapisan B Chinrat S Thasuntia A Plitponkarnpim T Chantarojanasiri 2005 A prospective, randomized double-blind study in children comparing two doses of nebulized l-epinephrine in postintubation croup J Med Assoc Thai 88 508 512 16146256 (Pubitemid 41073283)
7. IC Fernandes JC Fernandes A Cordeiro SH Hsin A Bousso B Ejzenberg Y Okay 2001 Efficacy and safety of nebulized l-epinephrine associated with dexamethasone in postintubation laringitis J Pediatr (Rio J) 77 179 188 10.1590/S0021-75572001000300008 (Pubitemid 32660610)
8. BH Wittekamp WN van Mook DH Tjan JH Zwaveling DC Bergmans 2009 Clinical review: post-extubation laryngeal edema and extubation failure in critically ill adult patients Crit Care 13 233 20017891 10.1186/cc8142
9. Y Waisman BL Klein DA Boenning GM Young JM Chamberlain R O'Donnell DW Ochsenschlager 1992 Prospective randomized double-blind study comparing l-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup) Pediatrics 89 302 306 1734400 1:STN:280: DyaK387jtFKjsg%3D%3D
10. A Sumboonnanonda S Suwanjutha S Sirinavin 1997 Randomized controlled trial of dexamethasone in infectious croup J Med Assoc Thai 80 262 265 9175396 1:STN:280:DyaK2szhvVCluw%3D%3D (Pubitemid 27339635)
11. JD Cherry 2008 Clinical practice. Croup N Engl J Med 358 384 391 18216359 10.1056/NEJMcp072022 1:CAS:528:DC%2BD1cXhtFCjsrc%3D (Pubitemid 351159238)
12. CL Bjornson DW Johnson 2008 Croup Lancet 371 329 339 18295000 10.1016/S0140-6736(08)60170-1 (Pubitemid 351754788)
13. Johnson D (2009) Croup. Clin Evid (Online):0321
14. MA Hegenbarth 2008 Preparing for pediatric emergencies: drugs to consider Pediatrics 121 433 443 18245435 10.1542/peds.2007-3284 (Pubitemid 351198471)
15. CL Gwinnutt WD Lord 1987 Nebulised adrenaline Anaesthesia 42 320 321 10.1111/j.1365-2044.1987.tb03059.x
16. Toaimah FH, Al-Ansari K (2011) Life-threatening cardiac arrhythmia after a single dose of nebulized epinephrine in pediatric emergency department. J Trop Pediatr Feb 1 [epub ahead of print]
17. MJ Butte BX Nguyen TJ Hutchison JW Wiggins JW Ziegler 1999 Pediatric myocardial infarction after racemic epinephrine administration Pediatrics 104 1 e9 10390295 10.1542/peds.104.1.e9 1:STN:280:DyaK1MzhvFSkuw%3D%3D
18. AH Kaji RJ Lewis 2010 Are we looking for superiority, equivalence, or noninferiority? Asking the right question and answering it correctly Ann Emerg Med 55 408 411 20172627 10.1016/j.annemergmed.2010.01.024
19. CR Westley EK Cotton JG Brooks 1978 Nebulized racemic epinephrine by IPPB for the treatment of croup: a double-blind study Am J Dis Child 132 484 487 347921 1:STN:280:DyaE1c7mtlegtA%3D%3D (Pubitemid 9128592)
20. Hopkins Johns (2002) The Harriet Lane handbook: a manual for pediatric house officers, 16th edn. St. Louis M, Mosby
21. D Fitzgerald C Mellis M Johnson H Allen P Cooper P Van Asperen 1996 Nebulized budesonide is as effective as nebulized adrenaline in moderately severe croup Pediatrics 97 722 725 8628614 1:STN:280:DyaK283gs1ejuw%3D%3D (Pubitemid 26138106)
22. Fisher LD, Dixon DO, Herson J, Frankowski RK, Hearron MS, Peace KE (1990) Intention to treat in clinical trials. In: Peace KE (ed) Statistical issues in drug research and development. Marcel Dekker, New York, pp 331-350
23. Khemani RG, Randolph A, Markovitz B (2009) Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev CD001000
24. AA Fifoot JY Ting 2007 Comparison between single-dose oral prednisolone and oral dexamethasone in the treatment of croup: a randomized, double-blinded clinical trial Emerg Med Australas 19 51 58 17305661 10.1111/j.1742-6723.2006. 00919.x (Pubitemid 46212262)
25. S Kristjansson K Berg-Kelly E Winso 1994 Inhalation of racemic adrenaline in the treatment of mild and moderately severe croup. Clinical symptom score and oxygen saturation measurements for evaluation of treatment effects Acta Paediatr 83 1156 1160 7841729 1:STN:280:DyaK2M7ktlyksQ%3D%3D (Pubitemid 24348083)
26. S Chub-Uppakarn P Sangsupawanich 2007 A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup Int J Pediatr Otorhinolaryngol 71 473 477 17208307 10.1016/j.ijporl.2006.11.016 1:STN:280:DC%2BD2s%2FkvFWmsQ%3D%3D (Pubitemid 46123585)
27. LM Taussig O Castro PH Beaudry WW Fox M Bureau 1975 Treatment of laryngotracheobronchitis (croup). Use of intermittent positive-pressure breathing and racemic epinephrine Am J Dis Child 29 790 793
28. AC Argent M Hatherill CJ Newth M Klein 2008 The effect of epinephrine by nebulization on measures of airway obstruction in patients with acute severe croup Intensive Care Med 34 138 147 17912497 10.1007/s00134-007-0855-0 1:CAS:528:DC%2BD1cXosl2lurc%3D