CD4+ T-cell response against human papillomavirus type 16 E6 protein is associated with a favorable clinical trend

Cancer Immunology, Immunotherapy

Volumn 61, Issue 1, 2012, Pages 63-70

  Kim, Kevin H ^a   Greenfield, William W ^a   Cannon, Martin J ^a   Coleman, Hannah N ^a   Spencer, Horace J ^a   Nakagawa, Mayumi ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CD4 T cell; Human papillomavirus; Regulatory T cell; Vaccine

Indexed keywords

PROTEIN E6; PROTEIN E7; VIRUS DNA;

ADULT; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA FINGERPRINTING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TREND STUDY;

ADOLESCENT; ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CERVICAL INTRAEPITHELIAL NEOPLASIA; DNA, VIRAL; FEMALE; HUMAN PAPILLOMAVIRUS 16; HUMANS; MIDDLE AGED; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS E7 PROTEINS; PAPILLOMAVIRUS INFECTIONS; REPRESSOR PROTEINS; T-LYMPHOCYTES, REGULATORY; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS; YOUNG ADULT;

EID: 84856708821     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1092-5     Document Type: Article

References (29)

1. P Pisani F Bray DM Parkin 2002 Estimates of the world-wide prevalence of cancer for 25 sites in the adult population Int J Cancer 97 1 72 81 10.1002/ijc.1571 11774246 10.1002/ijc.1571 1:CAS:528:DC%2BD3MXovFKrurk%3D (Pubitemid 33104397)
2. FT Cutts S Franceschi S Goldie X Castellsague S de Sanjose G Garnett WJ Edmunds P Claeys KL Goldenthal DM Harper L Markowitz 2007 Human papillomavirus and HPV vaccines: a review Bull World Health Organ 85 9 719 726 S0042-96862007000900018 18026629 10.2471/BLT.06.038414 1:STN:280: DC%2BD2snpt1SisA%3D%3D (Pubitemid 47416724)
3. Cancer Facts & Figures (2010) American Cancer Society
4. FX Bosch A Lorincz N Munoz CJ Meijer KV Shah 2002 The causal relation between human papillomavirus and cervical cancer J Clin Pathol 55 4 244 265 11919208 10.1136/jcp.55.4.244 1:STN:280:DC%2BD383jtlOisg%3D%3D (Pubitemid 34293391)
5. JM Walboomers MV Jacobs MM Manos FX Bosch JA Kummer KV Shah PJ Snijders J Peto CJ Meijer N Munoz 1999 Human papillomavirus is a necessary cause of invasive cervical cancer worldwide J Pathol 189 1 12 19 10.1002/(SICI)1096- 9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F 10451482 10.1002/(SICI)1096- 9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F 1:STN:280: DyaK1Mzot1CjsQ%3D%3D (Pubitemid 29406813)
6. Crum C (ed) (2004) Robbins & cotran pathologic basis of disease. 7th edn, W.B. Saunders Co., Philadelphia
7. LA Koutsky KK Holmes CW Critchlow CE Stevens J Paavonen AM Beckmann TA DeRouen DA Galloway D Vernon NB Kiviat 1992 A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection N Engl J Med 327 18 1272 1278 10.1056/NEJM199210293271804 1328880 10.1056/NEJM199210293271804 1:STN:280:DyaK3s%2FisVOgtQ%3D%3D
8. RM Richart BA Barron 1969 A follow-up study of patients with cervical dysplasia Am J Obstet Gynecol 105 3 386 393 0002-9378(69)90268-3 5810787 1:STN:280:DyaF1M3ovFWitw%3D%3D
9. AG Ostor 1993 Natural history of cervical intraepithelial neoplasia: a critical review Int J Gynecol Pathol 12 2 186 192 8463044 10.1097/00004347- 199304000-00018 1:STN:280:DyaK3s3hs1ektQ%3D%3D (Pubitemid 23095196)
10. JD Nash TW Burke WJ Hoskins 1987 Biologic course of cervical human papillomavirus infection Obstet Gynecol 69 2 160 162 3027635 1:STN:280:DyaL2s7hs1OksA%3D%3D (Pubitemid 17015526)
11. MJ Campion DJ McCance J Cuzick A Singer 1986 Progressive potential of mild cervical atypia: prospective cytological, colposcopic, and virological study Lancet 2 8501 237 240 S0140-6736(86)92067-2 2874275 10.1016/S0140-6736(86) 92067-2 1:STN:280:DyaL283otlOntg%3D%3D (Pubitemid 16098894)
12. J Melnikow J Nuovo AR Willan BK Chan LP Howell 1998 Natural history of cervical squamous intraepithelial lesions: a meta-analysis Obstet Gynecol 92 4 Pt 2 727 735 9764690 10.1016/S0029-7844(98)00245-2 1:STN:280: DyaK1cvjsFOiuw%3D%3D (Pubitemid 28440819)
13. AB Moscicki S Shiboski NK Hills KJ Powell N Jay EN Hanson S Miller KL Canjura-Clayton S Farhat JM Broering TM Darragh 2004 Regression of low-grade squamous intra-epithelial lesions in young women Lancet 364 9446 1678 1683 10.1016/S0140-6736(04)17354-6 15530628 10.1016/S0140-6736(04)17354-6 (Pubitemid 39458143)
14. AB Moscicki M Schiffman S Kjaer LL Villa 2006 Chapter 5: Updating the natural history of HPV and anogenital cancer Vaccine 24 suppl 3 S3/42 S3/51 10.1016/j.vaccine.2006.06.018 (Pubitemid 44308674)
15. M Nakagawa DP Stites S Farhat JR Sisler B Moss F Kong AB Moscicki JM Palefsky 1997 Cytotoxic T lymphocyte responses to E6 and E7 proteins of human papillomavirus type 16: relationship to cervical intraepithelial neoplasia J Infect Dis 175 4 927 931 9086151 10.1086/513992 1:CAS:528:DyaK2sXisFGqs7o%3D (Pubitemid 27142969)
16. M Nakagawa DP Stites S Patel S Farhat M Scott NK Hills JM Palefsky AB Moscicki 2000 Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens J Infect Dis 182 2 595 598 10.1086/315706 10915094 10.1086/315706 1:CAS:528:DC%2BD3cXmvVWgs7s%3D (Pubitemid 30651059)
17. M Nakagawa SK Gupta HN Coleman MA Sellers JA Banken WW Greenfield 2010 A favorable clinical trend is associated with CD8 T-cell immune responses to the human papillomavirus type 16 e6 antigens in women being studied for abnormal pap smear results J Low Genit Tract Dis 14 2 124 129 10.1097/LGT.0b013e3181c6f01e 20354421 10.1097/LGT.0b013e3181c6f01e
18. JW Molling TD de Gruijl J Glim M Moreno L Rozendaal CJ Meijer AJ van den Eertwegh RJ Scheper ME von Blomberg HJ Bontkes 2007 CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia Int J Cancer 121 8 1749 1755 10.1002/ijc.22894 17582606 10.1002/ijc.22894 1:CAS:528:DC%2BD2sXhtVyktLfF (Pubitemid 47417293)
19. SH van der Burg SJ Piersma A de Jong JM van der Hulst KM Kwappenberg M van den Hende MJ Welters JJ Van Rood GJ Fleuren CJ Melief GG Kenter R Offringa 2007 Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens Proc Natl Acad Sci USA 104 29 12087 12092 10.1073/pnas.0704672104 17615234 10.1073/pnas.0704672104 (Pubitemid 47185634)
20. EM de Villiers C Fauquet TR Broker HU Bernard H zur Hausen 2004 Classification of papillomaviruses Virology 324 1 17 27 10.1016/j.virol.2004.03. 033 15183049 10.1016/j.virol.2004.03.033 (Pubitemid 38737395)
21. N Munoz FX Bosch S de Sanjose R Herrero X Castellsague KV Shah PJ Snijders CJ Meijer 2003 Epidemiologic classification of human papillomavirus types associated with cervical cancer N Engl J Med 348 6 518 527 10.1056/NEJMoa021641 12571259 10.1056/NEJMoa021641 (Pubitemid 36159887)
22. M Nakagawa KH Kim AB Moscicki 2005 Patterns of CD8 T-cell epitopes within the human papillomavirus type 16 (HPV 16) E6 protein among young women whose HPV 16 infection has become undetectable Clin Diagn Lab Immunol 12 8 1003 1005 10.1128/CDLI.12.8.1003-1005.2005 16085919 1:CAS:528:DC%2BD2MXosValur4%3D
23. R Kaul T Dong FA Plummer J Kimani T Rostron P Kiama E Njagi E Irungu B Farah J Oyugi R Chakraborty KS MacDonald JJ Bwayo A McMichael SL Rowland-Jones 2001 CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects J Clin Invest 107 10 1303 1310 10.1172/JCI12433 11375420 10.1172/JCI12433 1:CAS:528:DC%2BD3MXjsl2nt74%3D (Pubitemid 32494547)
24. AS Kadish P Timmins Y Wang GY Ho RD Burk J Ketz W He SL Romney A Johnson R Angeletti M Abadi 2002 Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide Cancer Epidemiol Biomarkers Prev 11 5 483 488 12010863 1:CAS:528:DC%2BD38Xkslagt74%3D (Pubitemid 34517944)
25. JC Steele CH Mann S Rookes T Rollason D Murphy MG Freeth PH Gallimore S Roberts 2005 T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia Br J Cancer 93 2 248 259 10.1038/sj.bjc.6602679 15986031 10.1038/sj.bjc.6602679 1:STN:280: DC%2BD2MzntFyntQ%3D%3D (Pubitemid 41133212)
26. CL Trimble S Peng C Thoburn F Kos TC Wu 2010 Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3 Cancer Immunol Immunother 59 5 799 803 10.1007/s00262-009-0806-4 20012604 10.1007/s00262-009-0806-4 1:CAS:528:DC%2BC3cXis1yht74%3D
27. KH Kim R Dishongh AD Santin MJ Cannon S Bellone M Nakagawa 2006 Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell clone Cancer Immun 6 9 060609 16808432
28. M Heusinkveld MJ Welters MI van Poelgeest JM van der Hulst CJ Melief GJ Fleuren GG Kenter SH van der Burg 2011 The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors Int J Cancer 128 2 379 389 10.1002/ijc.25361 20473854 10.1002/ijc.25361 1:CAS:528:DC%2BC3cXhsVGrur3M
29. D Mougiakakos A Choudhury A Lladser R Kiessling CC Johansson 2010 Regulatory T cells in cancer Adv Cancer Res 107 57 117 10.1016/S0065-230X(10) 07003-X 20399961 10.1016/S0065-230X(10)07003-X 1:CAS:528:DC%2BC3cXovFagsb4%3D