High Epstein-Barr virus-specific T-cell counts are associated with near-zero likelihood of acute myeloid leukemia relapse after hematopoietic cell transplantation

Leukemia

Volumn 26, Issue 2, 2012, Pages 359-362

  Hoegh Petersen, M ^a   Sy, S ^a   Ugarte Torres, A ^a   Williamson, T S ^a   Eliasziw, M ^a   Mansoor, A ^b   Liu, Y ^a   Liu, S ^a   Podgorny, P ^a   Khan, F ^a   Duggan, P R ^b   Stewart, D A ^b   Russell, J A ^b   Storek, J ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b ALBERTA HEALTH SERVICES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS ANTIGEN;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIGEN SPECIFICITY; CANCER STAGING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPSTEIN BARR VIRUS; FOLLOW UP; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INFECTION CONTROL; INFECTION RISK; LETTER; LEUKEMIA RELAPSE; LYMPHOCYTE COUNT; MONONUCLEAR CELL; NATURAL KILLER CELL; NONHODGKIN LYMPHOMA; PATIENT ASSESSMENT; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TH1 CELL; VARICELLA ZOSTER VIRUS; VIRUS REACTIVATION;

HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPESVIRUS 4, HUMAN; HUMANS; LEUKEMIA, MYELOID, ACUTE; LIKELIHOOD FUNCTIONS; LYMPHOCYTE COUNT; RECURRENCE; T-LYMPHOCYTES;

EID: 84856693404     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.195     Document Type: Letter

References (8)

1. Atkinson KCR, Ritz J, Fibbe WE, Ljungman P, Brenner MK. Clinical Bone Marrow and Blood Stem Cell Transplantation. Cambrigde University Press: Cambridge, 2004.
2. Ringden O, Karlsson H, Olsson R, Omazic B, Uhlin M. The allogeneic graft-versus-cancer effect. Br J Haematol 2009; 147: 614-633.
3. Kapp M, Stevanovic S, Fick K, Tan SM, Loeffler J, Opitz A et al. CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free survival after allo-SCT. Bone Marrow Transplant 2009; 43: 399-410.
4. Parkman R, Cohen G, Carter SL, Weinberg KI, Masinsin B, Guinan E et al. Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation. Biol Blood Marrow Transplant 2006; 12: 919-927.
5. Amir AL, D'Orsogna LJ, Roelen DL, van Loenen MM, Hagedoorn RS, de Boer R et al. Allo-HLA reactivity of virus-specific memory T cells is common. Blood 2010; 115: 3146-3157.
6. Nakamura R, Battiwalla M, Solomon S, Follmann D, Chakrabarti S, Cortez K et al. Persisting posttransplantation cytomegalovirus antigenemia correlates with poor lymphocyte proliferation to cytomegalovirus antigen and predicts for increased late relapse and treatment failure. Biol Blood Marrow Transplant 2004; 10: 49-57. (Pubitemid 38145739)
7. Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood 2008; 112: 4371-4383.
8. Ruggeri L, Mancusi A, Capanni M, Urbani E, Carotti A, Aloisi T et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood 2007; 110: 433-440. (Pubitemid 47026866)