UV methodology for determination of antichagasic drugs Nifurtimox and Benznidazol in blood;Metodología UV para la determinación de los antichagásicos Nifurtimox y benznidazol en sangre

Acta Bioquimica Clinica Latinoamericana

Volumn 45, Issue 3, 2011, Pages 463-470

  Bulffer, Romina Fernanda ^a   Castro, José Alberto ^a   Fanelli, Silvia Laura ^a  

^a Farmacéutica ^*  (Argentina)

Author keywords

Benznidazol; Blood; Chagas' Disease; Nifurtimox; Spectrophotometry

Indexed keywords

RATTUS;

EID: 84856664960     PISSN: 03252957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. Rassi Jr A, Rassi A, Marin-Neto JA. Chagas heart disease: pathophysiologic, prognostic factors and risk stratification. Mem Inst Oswaldo Cruz 2009;104(Suppl. I): 152-8.
2. Schofield CJ, Jannin J, Salvatellan R. The future of Chagas disease control. Trends Parasitol 2006;22:583-8. (Pubitemid 44781088)
3. Jannin J, Villa L. An overview of Chagas disease treatment. Mem Inst Oswaldo Cruz 2007;102(Suppl. I): 95-7. (Pubitemid 350146008)
4. Rodriguez Coura J, de Castro SL. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 2002;97(1):3-24. (Pubitemid 135746197)
5. Castro JA, Montalto de Mecca M, Bartel LC. Toxic side effects of drugs used to treat Chagas disease (American Trypanosomiasis). Hum Exp Toxicol 2006;25:471-9. (Pubitemid 44384589)
6. Castro JA, de Toranzo EG. Toxic effects of Nifurtimox and Benznidazole, two drugs used against American Trypanosomiasis (Chagas disease). Biomed Environ Sci 1988;1:19-33.
7. Rodriguez Coura J. Present situation and strategies for Chagas disease chemotherapy - a proposal. Mem Inst Oswaldo Cruz 2009;104(4):549-54.
8. Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, et al. Long-term cardiac outcomes of treating chronic Chagas'disease in the Benznidazole versus no treatment. Ann Intern Med 2006;144:724-34. (Pubitemid 46780632)
9. Perez-Molina JA, Perez-Ayala A, Moreno S, Fernandez-Gonzalesz MC, Zamora J, Lopez-Velez R. Use of benznidazole to treat chronic Chagas'disease: a systemic review with a meta-analysis. J Anticrobial Chemother 2009;64(6):1139-47.
10. Sosa-Estani S, Viotti R, Segura EL. Therapy, diagnosis and prognosis of chronic Chagas'disease. Insight gained in Argentina. Mem Inst Oswaldo Cruz 2009;104(Suppl. 1):167-80.
11. Díaz G, Rodríguez de Castro C, Montalto de Mecca M, Castro JA. Benznidazole-induced ultrastructural and biochemical alterations in rat colon. Acta Pharmacol Sin 2000;21(11):961-6.
12. Montalto de Mecca M, Rodriguez de Castro C, Díaz EG, Castro JA. Alteraciones ultraestructurales en la mucosa del colon de ratas tratadas con Nifurtimox. Medicina (Buenos Aires) 2001;61:67-72. (Pubitemid 32224366)
13. Rodríguez de Castro C, Montalto de Mecca M, Fanelli SL, Cignoli de Ferreyra E, Díaz EG, Castro JA. Benznidazoleinduced ultrastructural and biochemical alterations in rat esophagus. Toxicology 2003;191:189-98. (Pubitemid 37329464)
14. Bartel LC, Montalto de Mecca M, Fanelli SL, Rodriguez de Castro C, Díaz EG, Castro JA. Early Nifurtimox-induced biochemical and ultrstructural alterations in rat heart. Hum Exp Toxicol 2007;26:781-8. (Pubitemid 350221392)
15. Montalto de Mecca M, Bartel LC, Rodriguez de Castro C, Castro JA. Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects. Mem Inst Oswaldo Cruz 2008;103(6):549-53.
16. General Chapter 1225, Validation of compendial methods, United States Pharmacopeia 30, National Formulary 25, Rockville, Md., USA, The United States Pharmacopeial Convention Inc., 2007.
17. Bioanalytical Method Validation. US Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER). Center for Veterinary Medicine (CVM), 2001.
18. Q2B Validation of Analytical Procedures: Methodology. US Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER). Center for Veterinary Medicine (CVM). International Conference Harmonization (ICH), 1996.
19. Gad SC, Principles and Methods in Toxicology. Philadelphia: Taylor & Francis; 2001.