Caveolin-1 expression regulates blood-retinal barrier permeability and retinal neovascularization in oxygen-induced retinopathy

Clinical and Experimental Ophthalmology

Volumn 40, Issue 1, 2012, Pages

  Tian, Xiao Feng ^a   Xia, Xiao Bo ^a   Xu, Hui Zhuo ^a   Xiong, Si Qi ^a   Jiang, Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Blood retinal barrier; Caveolin 1; Retinal neovascularization; SiRNA

Indexed keywords

ALBUMIN; CAVEOLIN 1; MESSENGER RNA; OXYGEN; SMALL INTERFERING RNA;

AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD RETINA BARRIER; CELL NUCLEUS; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE ANGIOGRAPHY; HISTOPATHOLOGY; HYPOXIA; MEMBRANE PERMEABILITY; MORPHOLOGY; MOUSE; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; RETINA NEOVASCULARIZATION; RETINOPATHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITREOUS BODY; WESTERN BLOTTING;

ALBUMINS; ANIMALS; ANIMALS, NEWBORN; BLOOD-RETINAL BARRIER; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CAVEOLIN 1; CELL COUNT; DISEASE MODELS, ANIMAL; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION REGULATION; HUMANS; INFANT, NEWBORN; INTRAVITREAL INJECTIONS; MICE; MICE, INBRED C57BL; OXYGEN; PLASMIDS; RETINAL NEOVASCULARIZATION; RETINOPATHY OF PREMATURITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84856648620     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2011.02656.x     Document Type: Article

References (30)

1. Afzal A, Shaw LC, Ljubimov AV, Boulton ME, Segal MS, Grant MB. Retinal and choroidal microangiopathies: therapeutic opportunities. Microvasc Res 2007; 74: 131-44.
2. Rosenfeld PJ, Rich RM, Lalwani GA. Ranibizumab: phase III clinical trial results. Ophthalmol Clin North Am 2006; 19: 361-72.
3. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-39.
4. Dvorak HF. Rous-Whipple award lecture. How tumors make bad blood vessels and stroma. Am J Pathol 2003; 162: 1747-57.
5. Hofman P, Blaauwgeers HG, Tolentino MJ etal. VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations. Curr Eye Res 2000; 21: 637-45.
6. Pascariu M, Bendayan M, Ghitescu L. 2004; Correlated endothelial caveolin overexpression and increased transcytosis in experimental diabetes. J Histochem Cytochem 52: 65-76.
7. Klaassen I, Hughes JM, Vogels IM, Schalkwijk CG, Van Noorden CJ, Schlingemann RO. Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. Exp Eye Res 2009; 89: 4-15.
8. Smith LE, Wesolowski E, McLellan A etal. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35: 101-11.
9. Song L, Ge S, Pachter JS. Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells. Blood 2007; 109: 1515-23.
10. Schlingemann RO, Hofman P, Vrensen GF, Blaauwgeers HG. Increased expression of endothelial antigen PAL-E in human diabetic retinopathy correlates with microvascular leakage. Diabetologia 1999; 42: 596-602.
11. Nakajima M, Cooney MJ, Tu AH etal. Normalization of retinal vascular permeability in experimental diabetes with genistein. Invest Ophthalmol Vis Sci 2001; 42: 2110-14.
12. Gu X, Samuel S, El-Shabrawey M etal. Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci 2002; 43: 496-502.
13. Zhang SX, Sima J, Shao C etal. Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes. Diabetologia 2004; 47: 124-31.
14. Tiruppathi C, Shimizu J, Miyawaki-Shimizu K etal. Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem 2008; 283: 4210-18.
15. Hu G, Vogel SM, Schwartz DE, Malik AB, Minshall RD. Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability. Circ Res 2008; 102: 120-31.
16. Schubert W, Frank PG, Razani B, Park DS, Chow CW, Lisanti MP. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J Biol Chem 2001; 276: 48619-22.
17. Drab M, Verkade P, Elger M etal. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001; 293: 2449-52.
18. Razani B, Engelman JA, Wang XB etal. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 2001; 276: 38121-38.
19. Nag S, Venugopalan R, Stewart DJ. Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown. Acta Neuropathol (Berl) 2007; 114: 459-69.
20. Ui-Tei K, Naito Y, Takahashi F etal. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res 2004; 32: 936-48.
21. Masuda I, Matsuo T, Yasuda T. Matsuo Nogene transfer with the intraocular tissues by different routes of administration. Invest Ophthalmol Vis Sci 1996; 37: 1914-20.
22. Bullejos M, Bowles J, Koopman P. Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression. Dev Dyn 2002; 225: 95-9.
23. Yokomori H, Oda M, Yoshimura K etal. Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral contraction in sinusoidal endothelial cells. Liver Int 2009; 29: 266-76.
24. Straub AC, Stolz DB, Ross MA etal. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 2007; 45: 205-12.
25. Liu J, Wang XB, Park DS, Lisanti MP. Caveolin-1 expression enhances endothelial capillary tubule formation. J Biol Chem 2002; 277: 10661-8.
26. Woodman SE, Ashton AW, Schubert W etal. Caveolin-1 knock-out mice show an impaired angiogenic response to exogenous stimuli. Am J Pathol 2003; 162: 2059-68.
27. Griffoni C, Spisni E, Santi S, Riccio M, Guarnieri T, Tomasi V. Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2000; 276: 756-61.
28. Sonveaux P, Martinive P, DeWever J etal. Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis. Circ Res 2004; 95: 154-61.
29. Bauer PM, Yu J, Chen Y etal. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci USA 2005; 102: 204-9.
30. Chang SH, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular permeability and pathological angiogenesis in caveolin-1-null mice. Am J Pathol 2009; 175: 1768-76.