Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1598-1601

  Zitko, Jan ^a   Jampilek, Josef ^b   Dobrovolný, Lukaš ^a   Svobodova, Michaela ^c   Kuneš, Jiři ^a   Doležal, Martin ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^c Pardubice Regional Hospital   (Czech Republic)

Author keywords

Alkyl chain homology; Antimycobacterial activity; Lipophilicity; Pyrazinamide derivatives; Structure activity relationships

Indexed keywords

3 (HEPTYLAMINO)PYRAZINE 2,5 DICARBONITRILE; 3 (HEXYLAMINO)PYRAZINE 2,5 DICARBONITRILE; 3 AMINOPYRAZINE 2,5 DICARBONITRILE DERIVATIVE; ANTIMYCOBACTERIAL AGENT; PYRAZINAMIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS;

EID: 84856641436     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.129     Document Type: Article

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