A phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: Preliminary results of the ACOSOG Z6041 trial

Annals of Surgical Oncology

Volumn 19, Issue 2, 2012, Pages 384-391

  Garcia Aguilar, Julio ^a   Shi, Qian ^b   Thomas Jr , Charles R ^c   Chan, Emily ^d   Cataldo, Peter ^e   Marcet, Jorge ^f   Medich, David ^g   Pigazzi, Alessio ^a   Oommen, Samuel ^h   Posner, Mitchell C ⁱ  

^a City of Hope ^*  (United States)

^b MAYO CLINIC   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF VERMONT   (United States)

^f TAMPA GENERAL HOSPITAL   (United States)

^g Allegheny Cancer Center   (United States)

^h John Muir Hospital   (United States)

ⁱ UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; OXALIPLATIN;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; AGED; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; LOCAL EXCISION; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; PAIN; PREOPERATIVE COMPLICATION; RECTUM CANCER; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; ORGANOPLATINUM COMPOUNDS; PROSPECTIVE STUDIES; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 84856640225     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-011-1933-7     Document Type: Article

References (37)

1. KC Peeters CA Marijnen ID Nagtegaal, et al. 2007 The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma Ann Surg 246 693 701 17968156 10.1097/01.sla.0000257358.56863.ce
2. NB Merchant JG Guillem PB Paty, et al. 1999 T3N0 rectal cancer: results following sharp mesorectal excision and no adjuvant therapy J Gastrointest Surg 3 642 647 10554372 10.1016/S1091-255X(99)80087-0 1:STN:280: DC%2BD3c%2FitF2qtw%3D%3D
3. E Leo F Belli S Andreola, et al. 1996 Total rectal resection, mesorectum excision, and coloendoanal anastomosis: a therapeutic option for the treatment of low rectal cancer Ann Surg Oncol 3 336 343 8790845 10.1007/BF02305662 1:STN:280:DyaK28zot12rsw%3D%3D
4. RJ Heald EM Husband RD Ryall 1982 The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg 69 613 616 6751457 10.1002/bjs.1800691019 1:STN:280:DyaL3s%2Fitl2nsw%3D%3D
5. DB Chessin JG Guillem 2005 Abdominoperineal resection for rectal cancer: historic perspective and current issues Surg Oncol Clin N Am 14 569 586 15978430 10.1016/j.soc.2005.04.002
6. P Luna-Pérez S Rodríguez-Ramírez J Vega E Sandoval S Labastida 2001 Morbidity and mortality following abdominoperineal resection for low rectal adenocarcinoma Rev Invest Clin 53 388 395 11795103
7. J Camilleri-Brennan RJ Steele 2001 Objective assessment of morbidity and quality of life after surgery for low rectal cancer Colorectal Dis 4 61 66 10.1046/j.1463-1318.2002.00300.x
8. A Nesbakken K Nygaard T Bull-Njaa E Carlsen LM Eri 2000 Bladder and sexual dysfunction after mesorectal excision for rectal cancer Br J Surg 87 206 210 10671929 10.1046/j.1365-2168.2000.01357.x 1:STN:280:DC%2BD3c7jslynug%3D%3D
9. R Bleday E Breen JM Jessup A Burgess SM Sentovich G Steele Jr 1997 Prospective evaluation of local excision for small rectal cancers Dis Colon Rectum 40 388 392 9106685 10.1007/BF02258381 1:STN:280:DyaK2s3mtVGltw%3D%3D
10. ET Chen M Mohiuddin H Brodovsky G Fishbein G Marks 1994 Downstaging of advanced rectal cancer following combined pre-operative chemotherapy and high dose radiation Int J Radiat Oncol Biol Phys 30 169 175 8083110 1:STN:280:DyaK2czmsVyksQ%3D%3D
11. RS Chari DS Tyler MS Anscher L Russell BM Clary J Hathorn HF Seigler 1995 Pre-operative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum Ann Surg 221 778 786 7794081 10.1097/00000658-199506000-00016 1:STN:280:DyaK2MzhsVChtw%3D%3D
12. NA Janjan VS Khoo J Abbruzzese, et al. 1999 Tumor downstaging and sphincter preservation with pre-operative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience Int J Radiat Oncol Biol Phys 44 1027 1038 10421535 10.1016/S0360-3016(99)00099-1 1:STN:280:DyaK1Mzksl2jsQ%3D%3D
13. R Sauer H Becker W Hohenberger, et al. 2004 Pre-operative versus post-operative chemoradiotherapy for rectal cancer N Engl J Med 351 1731 1740 15496622 10.1056/NEJMoa040694 1:CAS:528:DC%2BD2cXovFSksbo%3D
14. M Mohiuddin G Marks J Bannon 1994 High-dose pre-operative radiation and full thickness local excision: a new option for selected T3 distal rectal cancers Int J Radiat Oncol Biol Phys 30 845 849 7960986 1:STN:280: DyaK2M%2FkvFOhsg%3D%3D
15. CJ Kim TJ Yeatman D Coppola, et al. 2001 Local excision of T2 and T3 rectal cancers after downstaging chemoradiation Ann Surg 234 352 358 11524588 10.1097/00000658-200109000-00009 1:STN:280:DC%2BD3MvotVylsA%3D%3D
16. L Ruo JG Guillem BD Minsky SH Quan PB Paty AM Cohen 2002 Pre-operative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers Int J Colorectal Dis 17 54 58 12018456 10.1007/s003840100327 1:STN:280:DC%2BD383nslGltg%3D%3D
17. SR Schell RA Zlotecki WM Mendenhall RW Marsh JN Vauthey EM Copeland 3rd 2002 Transanal excision of locally advanced rectal cancers downstaged using neoadjuvant chemoradiotherapy J Am Coll Surg 194 584 590 12025835 10.1016/S1072-7515(02)01128-6
18. M Bonnen C Crane JN Vauthey, et al. 2004 Long-term results using local excision after pre-operative chemoradiation among selected T3 rectal cancer patients Int J Radiat Oncol Biol Phys 60 1098 1105 15519780 10.1016/j.ijrobp. 2004.07.368
19. T Borschitz D Wachtlin M Möhler H Schmidberger T Junginger 2008 Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer Ann Surg Oncol 15 712 720 18163173 10.1245/s10434-007-9732-x
20. RM Nair EM Siegel DT Chen, et al. 2008 Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum J Gastrointest Surg 12 1797 1805 18709419 10.1007/s11605-008-0647-z
21. G Lezoche M Baldarelli M Guerrieri AM Paganini A De Sanctis S Bartolacci E Lezoche 2008 A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy Surg Endosc 22 352 358 17943364 10.1007/s00464-007-9596-y 1:STN:280:DC%2BD1c%2FpvFaguw%3D%3D
22. Edge SB, Byrd DR, Compton CC et al. (eds) AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
23. BD Minsky AM Cohen WE Enker P Paty 1995 Sphincter preservation with pre-operative radiation therapy and coloanal anastomosis Int J Radiat Oncol Biol Phys 31 553 559 7852119 10.1016/0360-3016(94)00375-U 1:STN:280: DyaK2M7lsFSrtw%3D%3D
24. CH Crane JM Skibber BW Feig, et al. 2003 Response to pre-operative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma Cancer 97 517 524 12518377 10.1002/cncr.11075
25. R Sauer R Fietkau C Wittekind, et al. 2003 Adjuvant versus neoadjuvant combined modality treatment for locally advanced rectal cancer: the German rectal cancer study (CAO/ARO/AIO-94) Colorectal Dis 5 406 415 12925071 10.1046/j.1463-1318.2003.00509.x 1:STN:280:DC%2BD3svltFGitQ%3D%3D
26. C Rodel GG Grabenbauer T Papadopoulos W Hohenberger HJ Schmoll R Sauer 2003 Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer J Clin Oncol 21 3098 3104 12915600 10.1200/JCO.2003.02.505
27. Aschele C, Pinto S, Cordio G, et al. Perioperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: pathological response analysis of the Studio Terapia Adiuvante Retto (STAR)-01 randomized phase III trial. J Clin Oncol. 2009;27:18s (suppl; abstr CRA4008).
28. JP Gérard D Azria S Gourgou-Bourgade, et al. 2010 Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2 J Clin Oncol 28 1638 1644 20194850 10.1200/JCO.2009.25.8376
29. PL Baron WE Enker MF Zakowski C Urmacher 1995 Immediate vs. salvage resection after local treatment for early rectal cancer Dis Colon Rectum 38 177 181 7851173 10.1007/BF02052447 1:STN:280:DyaK2M7lsVSluw%3D%3D
30. D Hahnloser BG Wolff DW Larson J Ping S Nivatvongs 2005 Immediate radical resection after local excision of rectal cancer: an oncologic compromise? Dis Colon Rectum 48 429 437 15747069 10.1007/s10350-004-0900-9
31. GD Steele Jr JE Herndon R Bleday, et al. 1999 Sphincter-sparing treatment for distal rectal adenocarcinoma Ann Surg Oncol 6 433 441 10458680 10.1007/s10434-999-0433-5
32. JA Greenberg D Shibata JE Herndon 2nd GD Steele Jr R Mayer R Bleday 2008 Local excision of distal rectal cancer: an update of cancer and leukemia group B 8984 Dis Colon Rectum 51 1185 1191 18536973 10.1007/s10350-008-9231-6
33. JH Marks EB Valsdottir A DeNittis, et al. 2009 Transanal endoscopic microsurgery for the treatment of rectal cancer: comparison of wound complication rates with and without neoadjuvant radiation therapy Surg Endosc 23 1081 1087 19263164 10.1007/s00464-009-0326-5
34. RC Dresen GL Beets HJ Rutten, et al. 2009 Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part I. Are we able to predict tumor confined to the rectal wall? Radiology 252 71 80 19403847 10.1148/radiol.2521081200
35. MJ Lahaye GL Beets SM Engelen, et al. 2009 Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes? Radiology 252 81 91 19403848 10.1148/radiol.2521081364
36. Z Radovanovic M Breberina T Petrovic A Golubovic D Radovanovic 2008 Accuracy of endorectal ultrasonography in staging locally advanced rectal cancer after pre-operative chemoradiation Surg Endosc 22 2412 2415 18622554 10.1007/s00464-008-0037-3
37. SP Hiotis SM Weber AM Cohen, et al. 2002 Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients J Am Coll Surg 194 131 135 11848629 10.1016/S1072-7515(01)01159-0