Quantitative determination of odanacatib in human plasma using liquid-liquid extraction followed by liquid chromatography-tandem mass spectrometry analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 885-886, Issue , 2012, Pages 15-23

  Sun, Li ^a   Forni, Sabrina ^a   Schwartz, Michael S ^a   Breidinger, Sheila ^a   Woolf, Eric J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bioanalysis; Cathepsin K inhibitor; Human plasma; Liquid chromatography tandem mass spectrometry; Liquid liquid extraction; MK 0822; Odanacatib

Indexed keywords

BIOANALYSIS; CATHEPSIN K INHIBITOR; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MK-0822; ODANACATIB;

CHROMATOGRAPHY; ETHERS; ISOTOPES; LIQUIDS; MASS SPECTROMETRY; PLASMA (HUMAN);

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ACETYLSALICYLIC ACID; CAFFEINE; DEXTROMETHORPHAN; DIPHENHYDRAMINE; IBUPROFEN; KETOCONAZOLE; NICOTINE; ODANACATIB; PARACETAMOL; PHENIRAMINE; PHENYLEPHRINE; PSEUDOEPHEDRINE;

ACCURACY; ARTICLE; DILUTION; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; FREEZE THAWING; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; OSTEOPOROSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

BIPHENYL COMPOUNDS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LINEAR MODELS; LIQUID-LIQUID EXTRACTION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84856638270     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.004     Document Type: Article

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