Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: A novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant

Artificial Cells, Blood Substitutes, and Biotechnology

Volumn 40, Issue 1-2, 2012, Pages 28-37

  Bian, Yuzhu ^a   Rong, Zhixia ^a   Chang, Thomas Ming Swi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

catalase; Antioxidant; Blood substitute; Carbon dioxide transport; Carbonic anhydrase; Nanobiotechnology; PolyHb CA; PolyHb SOD CAT CA; Polyhemoglobin; Superoxide dismutase

Indexed keywords

-CATALASE; ANTIOXIDANT; CARBON DIOXIDE TRANSPORT; POLYHB-CA; POLYHB-SOD-CAT-CA; POLYHEMOGLOBIN; SUPER OXIDE DISMUTASE;

ALDEHYDES; BLOOD SUBSTITUTES; CARBON DIOXIDE; CARBONIC ANHYDRASE; NANOBIOTECHNOLOGY; ORGANIC ACIDS;

OXYGEN;

ANTIOXIDANT; BLOOD SUBSTITUTE; GLUTARALDEHYDE; POLYHEMOGLOBIN SUPEROXIDE DISMUTASE CATALASE CARBONIC ANHYDRASE; UNCLASSIFIED DRUG;

ARTICLE; BIOTECHNOLOGY; CARBON DIOXIDE TRANSPORT; CROSS LINKING; DRUG EFFECT; ENZYME ACTIVITY; ERYTHROCYTE; MOLECULAR WEIGHT; OXYGEN TRANSPORT;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; BIOTECHNOLOGY; BLOOD SUBSTITUTES; BUFFERS; CARBON DIOXIDE; CARBONIC ANHYDRASES; CATALASE; CATTLE; CROSS-LINKING REAGENTS; GLUTARAL; HEMOGLOBINS; KINETICS; MOLECULAR WEIGHT; OXYGEN; SUPEROXIDE DISMUTASE;

EID: 84856594476     PISSN: 10731199     EISSN: 15324184     Source Type: Journal    
DOI: 10.3109/10731199.2011.582041     Document Type: Article

References (21)

1. Chang, T. M. S. (1997). B lood Substitutes: Principles, Methods, Products and Clinical Trials Vol. 1. Basel: Karger Landes Systems.
2. Chang, T. M. S. (2007). ARTIFICIAL CELLS: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative Medicine, Bioencapsulation, Cell/Stem Cell Therapy. Singapore: World Science Publishers/Imperial College Press.
3. Winslow, R. M. (2005). B lood Substitutes. London: Elsevier Inc.
4. Chang, T. M. S. (1964). Semipermeable microcapsules. Science 146: 524-525.
5. Chang, T. M. S. (1971). Stabilization of enzyme by microencapsulation with a concentrated protein solution or by crosslinking with glutaraldehyde. Biochem Biophys Res Commun 44: 1531-1533.
6. Gould, S. A. et al. (2002). The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg 195: 445-452.
7. Levy, J. H. et al. (2002). Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a random ized, double-blind trial. J Thorac Cardiovasc Surg 124 (1): 35-42.
8. Geers, C., Gros, G. (2000). Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiol Reviews 80 (2): 681-715. (Pubitemid 30164947)
9. Arthurs, G. J., Sudhakar, M. (2005). Carbon dioxide transport. Cont Ed Anaesth 5 (6): 207-210. (Pubitemid 41722740)
10. Bauer, C., Gros, G., Bartels, H. (eds). (1980). B iophysics and Physiology of Carbon Dioxide: Symposium Held at the University of Regensburg (FRG), April 17-20, 1979. New York: Springer-Verlag.
11. Monanty, A. K., Kannan, K. K., Mahajan, S. K. (1998). Human carbonic anhydrase I: Effects of specific site mutations on its function. J. Biosci 3: 235-246. (Pubitemid 28429689)
12. Lindskog, S. (1997). Structure and mechanism of carbonic anhydrase. Pharmacol Ther 74 (1): 1-20. (Pubitemid 27337350)
13. D A gnillo, F., Chang, T. M. S. (1998). Polyhemoglobinsuperoxide dismutase, catalase as a blood substitute with antioxidant properties. Nature Biotechnol 16: 667-671. (Pubitemid 28334326)
14. Henry, R. P. (1991). Techniques for measuring carbonic anhydrase activity in vitro. In: Dodgson, S. J., Tashian, R. E., Gros, G., Carter, N. D. (eds.), The Carbonic Anhydrases. New York: Plenum Press, 119-126.
15. Wilbur, K. M., Anderson, N. G. (1948). Electrometric and colorimetric determination of carbonic anhydrase. J Biol Chem 176: 147-154.
16. Zhu, H.L., Du, Q.Q., Chen, C., Chang, T.M.S. (2010). The immunological properties of stroma-free polyhemolysate containing catalase and superoxide dismutase activities prepared by polymerized bovine stroma-free hemolysate. Artificial Cells, Blood Substitutes, and Biotechnology , 38: 57-63.
17. Guyton, A. C., Hall, J. E. (2000). T extbook of Medical Physiology, 10 th ed. Philadelphia: W. B. Saunders Company, 1-1064.
18. Philpot, F. J., Philpot, J. St. L. (1937). A modified colorimetric estimation of carbonic anhydrase. Biochem J. 30 (12): 2191-2193.
19. Hlastala, M. P., Berger, A. J. (2001). P hysiology of Respiration, 2 nd ed. New York: Oxford University Press, 1-275.
20. Chang, T. M. S. (2010). Blood replacement with engineered hemoglobin and hemoglobin nanocapsules. Wiley Interdisciplinary Reviews on Nanomedicine and Nanobiotechnology 2: 418-430.
21. Chang, T. M. S. (2009). Nanobiotechnology for hemoglobin based blood substitutes. Critical Care Clinics 25:373-382.