A novel method to load topotecan into liposomes driven by a transmembrane NH 4EDTA gradient

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 2, 2012, Pages 332-339

  Yang, Yuehui ^a   Ma, Yanling ^b   Wang, Shaoning ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antitumor efficacy; Liposomes; NH 4EDTA; Topotecan; Toxicity

Indexed keywords

AMMONIA; AMMONIUM SULFATE; BUFFER; CHOLESTEROL; EDETIC ACID; LIPOSOME; TOPOTECAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTIFICIAL MEMBRANE; CANCER INHIBITION; CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; ENCAPSULATION; MALE; MOUSE; NONHUMAN; PH; SINGLE DRUG DOSE; TOXICITY TESTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CHOLESTEROL; DOGS; EDETIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; LIPOSOMES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; QUATERNARY AMMONIUM COMPOUNDS; TOPOTECAN; TOXICITY TESTS, ACUTE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84856589992     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.10.013     Document Type: Conference Paper

References (35)

1. A.S. Taggar, J. Alnajim, M. Anantha, A. Thomas, M. Webb, E. Ramsay, and M.B. Bally Copper-topotecan complexation mediates drug accumulation into liposomes Journal of Controlled Release 114 2006 78 88 (Pubitemid 44128628)
2. J.F.S.LB. Pizzolato The camptothecins Lancet 361 Jun 28 2003 2235 2242
3. C. Broom Clinical studies of topotecan Annals of the New York Academy of Sciences 803 1996 264 271 (Pubitemid 27057994)
4. T.J. Herzog Update on the role of topotecan in the treatment of recurrent ovarian cancer Oncologist 7 2002 3 10
5. D.L. Emerson Liposomal delivery of camptothecins Pharmaceutical Science & Technology Today 3 2000 205 209 (Pubitemid 30364934)
6. P. Tardi, E. Choice, D. Masin, T. Redelmeier, M. Bally, and T.D. Madden Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models Cancer Research 60 2000 3389 3393 (Pubitemid 30482152)
7. Pantazis, P. Kozielski, A. Rodriguez, R. Petry, E. Wani, M. Wall, and B.M. Giovanella Therapeutic efficacy of camptothecin derivatives against human malignant melanoma xenografts Melanoma Research 4 1994 5 10 (Pubitemid 24127094)
8. P.W.C. Akkermans, Topoisomerase I inhibitors: The relevance of prolonged exposure for present, clinical development, in: P.J. B0S (Ed.), Prolonged tumor exposure to topoisomerase I inhibitor, The Netherlands, 1997, pp. 32-33.
9. Igor V. Zhigaltsev, Norbert Maurer, Quet-Fah Akhong, Robert Leone, Esther Leng, Jinfang Wang, Sean C. Semple, and Pieter R. Cullis Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention Journal of Controlled Release 104 2005 103 111 (Pubitemid 40615239)
10. A. Rahman, A. Kessler, N. More, B. Sikic, G. Rowden, P. Woolley, and P.S. Schein Liposomal protection of adriamycin-induced cardiotoxicity in mice Cancer Research 40 1980 1532 1537 (Pubitemid 10101997)
11. A. Gabizon, A. Dagan, D. Goren, Y. Barenholz, and Z. Fuks Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice Cancer Research 42 August 1982 4734 4739 (Pubitemid 13205982)
12. R.L. Hong, C.J. Huang, Y.L. Tseng, V.F. Pang, S.T. Chen, J.J. Liu, and C. FH Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? Clinical Cancer Research 5 Nov 1999 3645 3652
13. E.A. Forssen, and Z.A. Tokes Improved therapeutic benefits of doxorubicin by entrapment in anionic liposomes Cancer Research 43 1983 546 550 (Pubitemid 13193845)
14. R.L. Hong, Y.L. Tseng, and F.H. Chang Pegylated liposomal doxorubicin in treating a case of advanced hepatocellular carcinoma with severe hepatic dysfunction and pharmacokinetic study Annals of Oncology 11 2000 349 353
15. Y.H. Hsiang, R. Hertzberg, S. Hecht, and L. LF Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I Journal of Biological Chemistry 260 November 1985 14873 14878 (Pubitemid 16211028)
16. R.P. Hertzberg, M.J. Caranfa, and S.M. Hecht On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex Biochemistry 28 1989 4629 4638 (Pubitemid 19151036)
17. T.G. Burke Chemistry of the camptothecins in the bloodstream. Drug stabilization and optimization of activity Annals of the New York Academy of Sciences 803 December 1996 29 31 (Pubitemid 27057972)
18. M. Nishino, S.K. Ashiku, O.N. Kocher, R.L. Thurer, P.M. Boiselle, and H. Hatabu The thymus: a comprehensive review 1 Radiographics 26 2006 335 348
19. M.F. Cesta Normal structure, function, and histology of the spleen Toxicologic Pathology 34 2006 455 465 (Pubitemid 44652213)
20. J. Winston, Clean Out Your Veins and Arteries, in March 2010 17.
21. L. MR Chelation therapy for cardiovascular disease. Review and commentary Texas Heart Institute Journal 24 1997 81 89
22. E. Ernst Chelation therapy for coronary heart disease: an overview of all clinical investigations American Heart Journal 140 2000 139 141 (Pubitemid 30471253)
23. M.D. Daniel Dugi, S.A. Takemoto, The role of heavy metal detoxification in heart disease and cancers: a pilot study in detoxification of heavy metals, in: WESCON Biomedicine and Bioengineering Conference, Anaheim, California, USA, September 24, 2002.
24. M.D. Walter Blumer, and M.D. Elmer Cranton Ninety percent reduction in cancer mortality after chelation therapy with EDTA Journal of Advancement in Medicine 2 1989 1 2
25. Y. Kondo, K. Sato, H. Ohkawa, Y. Ueyama, T. Okabe, N. Sato, S. Asano, M. Mori, N. Ohsawa, and K. Kosaka Association of hypercalcemia with tumors producing colony-stimulating factor(s) Cancer Research 43 1983 2368 2374 (Pubitemid 13088792)
26. A.S. Taggar Copper-topotecan complexation: development of a novel liposomal formulation of topotecan The Faculty of Graduate Studies (Pathology and Laboratory Medicine) 2003 University of British Columbia 15 16
27. J. Gubernator, G. Chwastek, M. Korycinska, M. Stasiuk, G. Grynkiewicz, F. Lewrick, R. Süss, and A. Kozubek The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo Journal of Controlled Release 146 2010 68 75
28. D.C. Drummond, C.O. Noble, Z. Guo, M.E. Hayes, C. Connolly-Ingram, B.S. Gabriel, B. Hann, B. Liu, J.W. Park, K. Hong, C.C. Benz, J.D. Marks, and D.B. Kirpotin Development of a highly stable and targetable nanoliposomal formulation of topotecan Journal of Controlled Release 141 2010 13 21
29. S. Dadashzadeh, A.M. Vali, and M. Rezaie The effect of PEG coating on in vitro cytotoxicity and in vivo disposition of topotecan loaded liposomes in rats International Journal of Pharmaceutics 353 2008 251 259
30. S.A. Abraham, K. Edwards, G. Karlsson, N. Hudon, L.D. Mayer, and M.B. Bally An evaluation of transmembrane ion gradient-mediated encapsulation of topotecan within liposomes Journal of Controlled Release 96 2004 449 461 (Pubitemid 38553923)
31. E. Herrmann, J. Gerss, S. Bierer, T. Köpke, C. Bolenz, L. Hertle, and C. Wülfing Pre-treatment global quality of health predicts progression free survival in metastatic kidney cancer patients treated with sorafenib or sunitinib Journal of Cancer Research and Clinical Oncology 135 2009 61 67
32. R.J. Gralla Quality-of-life considerations in patients with advanced lung cancer: effect of topotecan on symptom palliation and quality of life Oncologist 9 2004 14 24
33. J. Fassberg, and V.J. Stella A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues Journal of Pharmaceutical Sciences 81 1992 676 684 (Pubitemid 23006796)
34. A.S. Kearney, K. Patel, and N.R. Palepu Preformulation studies to aid in the development of a ready-to-use injectable solution of the antitumor agent, topotecan International Journal of Pharmaceutics 127 1996 229 237 (Pubitemid 26091008)
35. F.K. Bedu-Addo, and L. Huang Interaction of PEG-phospholipid conjugates with phospholipid: implications in liposomal drug delivery Advanced Drug Delivery Reviews 16 1995 235 247