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Volumn 37, Issue 1, 2012, Pages 48-52

Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction

Author keywords

Muscle contraction; PDH regulation; PDK4

Indexed keywords

PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE COMPLEX;

EID: 84856570826     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/H11-136     Document Type: Article
Times cited : (16)

References (26)
  • 1
    • 0036128885 scopus 로고    scopus 로고
    • Intracellular ATP measured with luciferin/luciferase in isolated single mouse skeletal muscle fibres
    • doi:10. 1007/s00424-001-0756-y. PMID:11889583
    • Allen, D.G., Lannergren, J., and Westerblad, H. 2002. Intracellular ATP measured with luciferin/luciferase in isolated single mouse skeletal muscle fibres. Pflugers Arch. 443(5-6): 836-842. doi:10. 1007/s00424-001-0756-y. PMID:11889583.
    • (2002) Pflugers Arch. , vol.443 , Issue.5-6 , pp. 836-842
    • Allen, D.G.1    Lannergren, J.2    Westerblad, H.3
  • 2
    • 0031972736 scopus 로고    scopus 로고
    • Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
    • PMID:9405293
    • Bowker-Kinley, M.M., Davis, W.I., Wu, P.F., Harris, R.A., and Popov, K.M. 1998. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem. J. 329(1): 191-196. PMID:9405293.
    • (1998) Biochem. J. , vol.329 , Issue.1 , pp. 191-196
    • Bowker-Kinley, M.M.1    Davis, W.I.2    Wu, P.F.3    Harris, R.A.4    Popov, K.M.5
  • 3
    • 0025936701 scopus 로고
    • A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue
    • doi:10. 1016/0003-2697(91)90437-X. PMID:1799221
    • Constantin-Teodosiu, D., Cederblad, G., and Hultman, E. 1991. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Anal. Biochem. 198(2): 347-351. doi:10. 1016/0003-2697(91)90437-X. PMID:1799221.
    • (1991) Anal. Biochem. , vol.198 , Issue.2 , pp. 347-351
    • Constantin-Teodosiu, D.1    Cederblad, G.2    Hultman, E.3
  • 4
    • 0020613021 scopus 로고
    • Influence of fasting on glycogen depletion in rats during exercise
    • PMID:6629920
    • Dohm, G.L., Tapscott, E.B., Barakat, H.A., and Kasperek, G.J. 1983. Influence of fasting on glycogen depletion in rats during exercise. J. Appl. Physiol. 55(3): 830-833. PMID:6629920.
    • (1983) J. Appl. Physiol. , vol.55 , Issue.3 , pp. 830-833
    • Dohm, G.L.1    Tapscott, E.B.2    Barakat, H.A.3    Kasperek, G.J.4
  • 5
    • 33748446665 scopus 로고    scopus 로고
    • Effects of prior exercise and a low-carbohydrate diet on muscle sarcoplasmic reticulum function during cycling in women
    • doi:10.1152/japplphysiol.00052. 2006
    • Duhamel, T.A., Green, H.J., Perco, J.G., and Ouyang, J. 2006. Effects of prior exercise and a low-carbohydrate diet on muscle sarcoplasmic reticulum function during cycling in women. J. Appl. Physiol. 101(3): 695-706. doi:10.1152/japplphysiol.00052. 2006.
    • (2006) J. Appl. Physiol. , vol.101 , Issue.3 , pp. 695-706
    • Duhamel, T.A.1    Green, H.J.2    Perco, J.G.3    Ouyang, J.4
  • 6
    • 79958842796 scopus 로고    scopus 로고
    • PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: Effect of PDH kinase 1 compensation
    • doi:10.1152/ajpregu.00498.2010. PMID:21411764
    • Dunford, E.C., Herbst, E.A., Jeoung, N.H., Gittings, W., Inglis, J.G., Vandenboom, R., et al. 2011. PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300(6): R1487-R1493. doi:10.1152/ajpregu.00498.2010. PMID:21411764.
    • (2011) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.300 , Issue.6
    • Dunford, E.C.1    Herbst, E.A.2    Jeoung, N.H.3    Gittings, W.4    Inglis, J.G.5    Vandenboom, R.6
  • 7
    • 0142020833 scopus 로고    scopus 로고
    • Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration
    • PMID:12902322
    • Hildebrandt, A.L., Pilegaard, H., and Neufer, P.D. 2003. Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration. Am. J. Physiol. Endocrinol. Metab. 285(5): E1021-E1027. PMID:12902322.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285 , Issue.5
    • Hildebrandt, A.L.1    Pilegaard, H.2    Neufer, P.D.3
  • 8
    • 0034074642 scopus 로고    scopus 로고
    • Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding
    • doi:10.2337/diabetes.49.5.775. PMID: 10905486
    • Holness, M.J., Kraus, A., Harris, R.A., and Sugden, M.C. 2000. Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding. Diabetes, 49(5): 775-781. doi:10.2337/diabetes.49.5.775. PMID: 10905486.
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 775-781
    • Holness, M.J.1    Kraus, A.2    Harris, R.A.3    Sugden, M.C.4
  • 9
    • 50349094001 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice
    • doi:10.1152/ajpendo.00536.2007. PMID:18430968
    • Jeoung, N.H., and Harris, R.A. 2008. Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. Am. J. Physiol. Endocrinol. Metab. 295(1): E46-E54. doi:10.1152/ajpendo.00536.2007. PMID:18430968.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , Issue.1
    • Jeoung, N.H.1    Harris, R.A.2
  • 10
    • 33746863679 scopus 로고    scopus 로고
    • Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
    • doi:10. 1042/BJ20060125. PMID:16606348
    • Jeoung, N.H., Wu, P.F., Joshi, M.A., Jaskiewicz, J., Bock, C.B., DePaoli-Roach, A.A., and Harris, R.A. 2006. Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. Biochem. J. 397(3): 417-425. doi:10. 1042/BJ20060125. PMID:16606348.
    • (2006) Biochem. J. , vol.397 , Issue.3 , pp. 417-425
    • Jeoung, N.H.1    Wu, P.F.2    Joshi, M.A.3    Jaskiewicz, J.4    Bock, C.B.5    DePaoli-Roach, A.A.6    Harris, R.A.7
  • 11
    • 77449136006 scopus 로고    scopus 로고
    • Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle
    • doi:10.2337/db09-1032. PMID:19833896
    • Kiilerich, K., Gudmundsson, M., Birk, J.B., Lundby, C., Taudorf, S., Plomgaard, P., et al. 2010. Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle. Diabetes, 59(1): 26-32. doi:10.2337/db09-1032. PMID:19833896.
    • (2010) Diabetes , vol.59 , Issue.1 , pp. 26-32
    • Kiilerich, K.1    Gudmundsson, M.2    Birk, J.B.3    Lundby, C.4    Taudorf, S.5    Plomgaard, P.6
  • 12
    • 18044384124 scopus 로고    scopus 로고
    • PDH kinase inhibitors: A novel therapy for type II diabetes?
    • doi:10.1042/BST0330367. PMID: 15787608
    • Mayers, R.M., Leighton, B., and Kilgour, E. 2005. PDH kinase inhibitors: a novel therapy for type II diabetes? Biochem. Soc. Trans. 33(2): 367-370. doi:10.1042/BST0330367. PMID: 15787608.
    • (2005) Biochem. Soc. Trans. , vol.33 , Issue.2 , pp. 367-370
    • Mayers, R.M.1    Leighton, B.2    Kilgour, E.3
  • 13
    • 0348049838 scopus 로고    scopus 로고
    • AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2
    • doi:10.1042/BST0311168. PMID:14641019
    • Morrell, J.A., Orme, J., Butlin, R.J., Roche, T.E., Mayers, R.M., and Kilgour, E. 2003. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Biochem. Soc. Trans. 31(6): 1168-1170. doi:10.1042/BST0311168. PMID:14641019.
    • (2003) Biochem. Soc. Trans. , vol.31 , Issue.6 , pp. 1168-1170
    • Morrell, J.A.1    Orme, J.2    Butlin, R.J.3    Roche, T.E.4    Mayers, R.M.5    Kilgour, E.6
  • 14
    • 33744933166 scopus 로고    scopus 로고
    • Carbohydrate metabolism during prolonged exercise and recovery: Interactions between pyruvate dehydrogenase, fatty acids, and amino acids
    • doi:10.1152/ japplphysiol.00571.2005. PMID:16424076
    • Mourtzakis, M., Saltin, B., Graham, T., and Pilegaard, H. 2006. Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids. J. Appl. Physiol. 100(6): 1822-1830. doi:10.1152/ japplphysiol.00571.2005. PMID:16424076.
    • (2006) J. Appl. Physiol. , vol.100 , Issue.6 , pp. 1822-1830
    • Mourtzakis, M.1    Saltin, B.2    Graham, T.3    Pilegaard, H.4
  • 15
    • 79251576463 scopus 로고    scopus 로고
    • Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle
    • doi:10. 1113/jphysiol.2010.195982
    • Ørtenblad, N., Nielsen, J., Saltin, B., and Holmberg, H.C. 2011. Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle. J. Physiol. 589(3): 711-725. doi:10. 1113/jphysiol.2010.195982.
    • (2011) J. Physiol. , vol.589 , Issue.3 , pp. 711-725
    • Ørtenblad, N.1    Nielsen, J.2    Saltin, B.3    Holmberg, H.C.4
  • 16
    • 0033679675 scopus 로고    scopus 로고
    • Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    • PMID:11001762
    • Pilegaard, H., Ordway, G.A., Saltin, B., and Neufer, P.D. 2000. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am. J. Physiol. Endocrinol. Metab. 279(4): E806-E814. PMID:11001762.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279 , Issue.4
    • Pilegaard, H.1    Ordway, G.A.2    Saltin, B.3    Neufer, P.D.4
  • 17
    • 0027422164 scopus 로고
    • Pyruvate-dehydrogenase activity and acetyl group accumulation during exercise after different diets
    • PMID:8238502
    • Putman, C.T., Spriet, L.L., Hultman, E., Lindinger, M.I., Lands, L.C., Mckelvie, R.S., et al. 1993. Pyruvate-dehydrogenase activity and acetyl group accumulation during exercise after different diets. Am. J. Physiol. 265(5): E752-E760. PMID:8238502.
    • (1993) Am. J. Physiol. , vol.265 , Issue.5
    • Putman, C.T.1    Spriet, L.L.2    Hultman, E.3    Lindinger, M.I.4    Lands, L.C.5    McKelvie, R.S.6
  • 19
    • 34247131735 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
    • doi:10.1007/s00018-007-6380-z. PMID:17310282
    • Roche, T.E., and Hiromasa, Y. 2007. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell. Mol. Life Sci. 64(7-8): 830-849. doi:10.1007/s00018-007-6380-z. PMID:17310282.
    • (2007) Cell. Mol. Life Sci. , vol.64 , Issue.7-8 , pp. 830-849
    • Roche, T.E.1    Hiromasa, Y.2
  • 20
    • 9544245935 scopus 로고    scopus 로고
    • Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human
    • doi:10.1074/jbc. 271.37.22376. PMID:8798399
    • Rowles, J., Scherer, S.W., Xi, T., Majer, M., Nickle, D.C., Rommens, J.M., et al. 1996. Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J. Biol. Chem. 271(37): 22376-22382. doi:10.1074/jbc. 271.37.22376. PMID:8798399.
    • (1996) J. Biol. Chem. , vol.271 , Issue.37 , pp. 22376-22382
    • Rowles, J.1    Scherer, S.W.2    Xi, T.3    Majer, M.4    Nickle, D.C.5    Rommens, J.M.6
  • 21
    • 0033857489 scopus 로고    scopus 로고
    • Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet
    • PMID:10913026
    • St Amand, T.A., Spriet, L.L., Jones, N.L., and Heigenhauser, G.J. 2000. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. Am. J. Physiol. Endocrinol. Metab. 279(2): E275-E283. PMID:10913026.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279 , Issue.2
    • St Amand, T.A.1    Spriet, L.L.2    Jones, N.L.3    Heigenhauser, G.J.4
  • 22
    • 0036634105 scopus 로고    scopus 로고
    • Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia
    • doi:10.2174/1568008023340785. PMID: 12476789
    • Sugden, M.C., and Holness, M.J. 2002. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr. Drug Targets Immune Endocr. Metabol. Disord. 2(2): 151-165. doi:10.2174/1568008023340785. PMID: 12476789.
    • (2002) Curr. Drug Targets Immune Endocr. Metabol. Disord. , vol.2 , Issue.2 , pp. 151-165
    • Sugden, M.C.1    Holness, M.J.2
  • 23
    • 0037096150 scopus 로고    scopus 로고
    • Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man
    • doi:10.1113/jphysiol.2002.018820. PMID:12068055
    • Watt, M.J., Heigenhauser, G.J.F., Dyck, D.J., and Spriet, L.L. 2002. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. J. Physiol. 541(3): 969-978. doi:10.1113/jphysiol.2002.018820. PMID:12068055.
    • (2002) J. Physiol. , vol.541 , Issue.3 , pp. 969-978
    • Watt, M.J.1    Heigenhauser, G.J.F.2    Dyck, D.J.3    Spriet, L.L.4
  • 24
    • 4644282235 scopus 로고    scopus 로고
    • Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise
    • doi:10. 1152/japplphysiol.00132.2004. PMID:15169745
    • Watt, M.J., Heigenhauser, G.J.F., LeBlanc, P.J., Inglis, J.G., Spriet, L. L., and Peters, S.J. 2004. Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise. J. Appl. Physiol. 97(4): 1261-1267. doi:10. 1152/japplphysiol.00132.2004. PMID:15169745.
    • (2004) J. Appl. Physiol. , vol.97 , Issue.4 , pp. 1261-1267
    • Watt, M.J.1    Heigenhauser, G.J.F.2    LeBlanc, P.J.3    Inglis, J.G.4    Spriet, L.L.5    Peters, S.J.6
  • 25
    • 0031973056 scopus 로고    scopus 로고
    • Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
    • PMID:9405294
    • Wu, P., Sato, J., Zhao, Y., Jaskiewicz, J., Popov, K.M., and Harris, R.A. 1998. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem. J. 329(1): 197-201. PMID:9405294.
    • (1998) Biochem. J. , vol.329 , Issue.1 , pp. 197-201
    • Wu, P.1    Sato, J.2    Zhao, Y.3    Jaskiewicz, J.4    Popov, K.M.5    Harris, R.A.6
  • 26
    • 0032792498 scopus 로고    scopus 로고
    • Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes
    • doi:10.2337/diabetes.48.8. 1593. PMID:10426378
    • Wu, P., Inskeep, K., Bowker-Kinley, M.M., Popov, K.M., and Harris, R.A. 1999. Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes. Diabetes, 48(8): 1593-1599. doi:10.2337/diabetes.48.8. 1593. PMID:10426378.
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1593-1599
    • Wu, P.1    Inskeep, K.2    Bowker-Kinley, M.M.3    Popov, K.M.4    Harris, R.A.5


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