Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 2, 2012, Pages 239-245

  Nagai, Noriaki ^a   Ito, Yoshimasa ^a   Takeuchi, Noriko ^b  

^a KINKI UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

2 Hydroxypropyl cyclodextrin; Cataract; Disulfiram; ICR f rat; Methylcellulose

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; EYE DROPS; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICATARACT EFFECT; ANTIOXIDANT ACTIVITY; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; BODY TEMPERATURE; CATARACT; CONTROLLED STUDY; CORNEA; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RETENTION; EVENING DOSAGE; EXPERIMENTAL MODEL; GELATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MORNING DOSAGE; NONHUMAN; PHARMACODYNAMICS; RABBIT; RAT; RAT STRAIN;

ANIMALS; ANTIOXIDANTS; CATARACT; DISEASE MODELS, ANIMAL; DISULFIRAM; DRUG CARRIERS; MALE; METHYLCELLULOSE; OPHTHALMIC SOLUTIONS; RABBITS; RATS;

EID: 84856563749     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.239     Document Type: Article

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