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Volumn 129, Issue 2, 2012, Pages

A decision-tree approach to cost comparison of newborn screening strategies for cystic fibrosis

Author keywords

Costs; Cystic fibrosis; DNA; Immunoreactive trypsinogen; Newborn screening; Sensitivity

Indexed keywords

TRYPSINOGEN;

EID: 84856551093     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-0096     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 0018769118 scopus 로고
    • Dried-blood spot screening for cystic fibrosis in the newborn
    • Crossley JR, Elliott RB, Smith PA. Dried-blood spot screening for cystic fibrosis in the newborn. Lancet. 1979;1(8114):472-474 (Pubitemid 9127240)
    • (1979) Lancet , vol.1 , Issue.8114 , pp. 472-474
    • Crossley, J.R.1    Elliott, R.B.2    Smith, P.A.3
  • 2
    • 4944235029 scopus 로고    scopus 로고
    • Newborn screening for cystic fibrosis: Evaluation of benefits and risks and recommendations for state newborn screening programs
    • CDC
    • Grosse SD, Boyle CA, Botkin JR, et al CDC. Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs. MMWR Recomm Rep. 2004;53(RR-13):1-36
    • (2004) MMWR Recomm Rep , vol.53 , Issue.RR-13 , pp. 1-36
    • Grosse, S.D.1    Boyle, C.A.2    Botkin, J.R.3
  • 3
    • 25844517871 scopus 로고    scopus 로고
    • Newborn screening for cystic fibrosis: An opportunity to improve care and outcomes
    • DOI 10.1016/j.jpeds.2005.08.016, PII S0022347605007547
    • Campbell PW, III, White TB. Newborn screening for cystic fibrosis: an opportunity to improve care and outcomes. J Pediatr. 2005;147(suppl 3):S2-S5 (Pubitemid 41400251)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Campbell III, P.W.1    White, T.B.2
  • 4
    • 27744550646 scopus 로고    scopus 로고
    • Newborn screening: Toward a uniform screening panel and system
    • Department of Health and Human Services
    • Department of Health and Human Services. Newborn screening: toward a uniform screening panel and system. 70 Federal Register 11247 (2005)
    • (2005) 70 Federal Register , pp. 11247
  • 5
    • 0027527564 scopus 로고
    • Application of DNA analysis in a population-screening program for neonatal diagnosis of cystic fibrosis (CF): Comparison of screening protocols
    • Gregg RG, Wilfond BS, Farrell PM, Laxova A, Hassemer D, Mischler EH. Application of DNA analysis in a population-screening program for neonatal diagnosis of cystic fibrosis (CF): comparison of screening protocols. Am J Hum Genet. 1993;52(3):616-626 (Pubitemid 23311332)
    • (1993) American Journal of Human Genetics , vol.52 , Issue.3 , pp. 616-626
    • Gregg, R.G.1    Wilfond, B.S.2    Farrell, P.M.3    Laxova, A.4    Hassemer, D.5    Mischler, E.H.6
  • 6
    • 61549085334 scopus 로고    scopus 로고
    • Clarification of laboratory and clinical variables that influence cystic fibrosis newborn screening with initial analysis of immunoreactive trypsinogen
    • Available at
    • Kloosterboer M, Hoffman G, Rock MJ, et al. Clarification of laboratory and clinical variables that influence cystic fibrosis newborn screening with initial analysis of immunoreactive trypsinogen. Pediatrics. 2009;123(2). Available at: www.pediatrics.org/cgi/content/full/123/2/e338
    • (2009) Pediatrics , vol.123 , Issue.2
    • Kloosterboer, M.1    Hoffman, G.2    Rock, M.J.3
  • 7
    • 49349101590 scopus 로고    scopus 로고
    • Newborn screening for cystic fibrosis: A lesson in public health disparities
    • Ross LF. Newborn screening for cystic fibrosis: a lesson in public health disparities. J Pediatr. 2008;153(3):308-313
    • (2008) J Pediatr , vol.153 , Issue.3 , pp. 308-313
    • Ross, L.F.1
  • 8
    • 67349143664 scopus 로고    scopus 로고
    • European best practice guidelines for cystic fibrosis neonatal screening
    • Castellani C, Southern KW, Brownlee K, et al. European best practice guidelines for cystic fibrosis neonatal screening. J Cyst Fibros. 2009;8(3):153-173
    • (2009) J Cyst Fibros , vol.8 , Issue.3 , pp. 153-173
    • Castellani, C.1    Southern, K.W.2    Brownlee, K.3
  • 11
    • 25844504609 scopus 로고    scopus 로고
    • Assessing the cost of cystic fibrosis diagnosis and treatment
    • DOI 10.1016/j.jpeds.2005.08.018, PII S0022347605007638
    • Rosenberg MA, Farrell PM. Assessing the cost of cystic fibrosis diagnosis and treatment. J Pediatr. 2005;147(suppl 3):S101-S105 (Pubitemid 41400269)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Rosenberg, M.A.1    Farrell, P.M.2
  • 12
    • 33749073438 scopus 로고    scopus 로고
    • Cost-effectiveness of 4 neonatal screening strategies for cystic fibrosis
    • DOI 10.1542/peds.2005-2782
    • van den Akker-van Marle ME, Dankert HM, Verkerk PH, Dankert-Roelse JE. Cost-effectiveness of 4 neonatal screening strategies for cystic fibrosis. Pediatrics. 2006;118(3):896-905 (Pubitemid 46090029)
    • (2006) Pediatrics , vol.118 , Issue.3 , pp. 896-905
    • Van Den A.-van, M.M.E.1    Dankert, H.M.2    Verkerk, P.H.3    Dankert-Roelse, J.E.4
  • 13
    • 33846910543 scopus 로고    scopus 로고
    • Cystic fibrosis diagnosed after 2 months of age leads to worse outcomes and requires more therapy
    • DOI 10.1542/peds.2006-1498
    • Sims EJ, Clark A, McCormick J, Mehta G, Connett G, Mehta A; United Kingdom Cystic Fibrosis Database Steering Committee. Cystic fibrosis diagnosed after 2 months of age leads to worse outcomes and requires more therapy. Pediatrics. 2007;119(1):19-28 (Pubitemid 46397838)
    • (2007) Pediatrics , vol.119 , Issue.1 , pp. 19-28
    • Sims, E.J.1    Clark, A.2    McCormick, J.3    Mehta, G.4    Connett, G.5    Mehta, A.6
  • 14
    • 34047269755 scopus 로고    scopus 로고
    • Economic implications of newborn screening for cystic fibrosis: A cost of illness retrospective cohort study
    • DOI 10.1016/S0140-6736(07)60565-0, PII S0140673607605650
    • Sims EJ, Mugford M, Clark A, et al UK Cystic Fibrosis Database Steering Committee. Economic implications of newborn screening for cystic fibrosis: a cost of illness retrospective cohort study. Lancet. 2007;369(9568):1187-1195 (Pubitemid 46546435)
    • (2007) Lancet , vol.369 , Issue.9568 , pp. 1187-1195
    • Sims, E.J.1    Mugford, M.2    Clark, A.3    Aitken, D.4    McCormick, J.5    Mehta, G.6    Mehta, A.7
  • 15
    • 77950587904 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of screening urine dipsticks in well-child care
    • Sekhar DL, Wang L, Hollenbeak CS, Widome MD, Paul IM. A cost-effectiveness analysis of screening urine dipsticks in well-child care. Pediatrics. 2010;125(4):660-663
    • (2010) Pediatrics , vol.125 , Issue.4 , pp. 660-663
    • Sekhar, D.L.1    Wang, L.2    Hollenbeak, C.S.3    Widome, M.D.4    Paul, I.M.5
  • 16
    • 33646136004 scopus 로고    scopus 로고
    • The cost-effectiveness of neonatal screening for cystic fibrosis: An analysis of alternative scenarios using a decision model
    • Simpson N, Anderson R, Sassi F, et al. The cost-effectiveness of neonatal screening for cystic fibrosis: an analysis of alternative scenarios using a decision model. Cost Eff Resour Alloc. 2005;3:8
    • (2005) Cost Eff Resour Alloc , vol.3 , pp. 8
    • Simpson, N.1    Anderson, R.2    Sassi, F.3
  • 18
    • 0029989213 scopus 로고    scopus 로고
    • The incidence of cystic fibrosis
    • DOI 10.1002/(SICI)1097-0258(19960315)15:5<449::AID-SIM173>3.0.CO;2- X
    • Kosorok MR, Wei WH, Farrell PM. The incidence of cystic fibrosis. Stat Med. 1996;15(5):449-462 (Pubitemid 26073580)
    • (1996) Statistics in Medicine , vol.15 , Issue.5 , pp. 449-462
    • Kosorok, M.R.1    Wei, W.-H.2    Farrell, P.M.3
  • 19
    • 40049109565 scopus 로고    scopus 로고
    • Newborn screening showing decreasing incidence of cystic fibrosis
    • DOI 10.1056/NEJMc0707530
    • Hale JE, Parad RB, Comeau AM. Newborn screening showing decreasing incidence of cystic fibrosis. N Engl J Med. 2008;358(9):973-974 (Pubitemid 351397113)
    • (2008) New England Journal of Medicine , vol.358 , Issue.9 , pp. 973-974
    • Hale, J.E.1    Parad, R.B.2    Comeau, A.M.3
  • 20
    • 72549092953 scopus 로고    scopus 로고
    • Association between carrier screening and incidence of cystic fibrosis
    • Castellani C, Picci L, Tamanini A, Girardi P, Rizzotti P, Assael BM. Association between carrier screening and incidence of cystic fibrosis. JAMA. 2009;302(23):2573-2579
    • (2009) JAMA , vol.302 , Issue.23 , pp. 2573-2579
    • Castellani, C.1    Picci, L.2    Tamanini, A.3    Girardi, P.4    Rizzotti, P.5    Assael, B.M.6
  • 21
    • 77953745081 scopus 로고    scopus 로고
    • Declining prevalence of cystic fibrosis since the introduction of newborn screening
    • Massie J, Curnow L, Gaffney L, Carlin J, Francis I. Declining prevalence of cystic fibrosis since the introduction of newborn screening. Arch Dis Child. 2010;95(7):531-533
    • (2010) Arch Dis Child , vol.95 , Issue.7 , pp. 531-533
    • Massie, J.1    Curnow, L.2    Gaffney, L.3    Carlin, J.4    Francis, I.5
  • 22
    • 0035746363 scopus 로고    scopus 로고
    • Laboratory standards and guidelines for population-based cystic fibrosis carrier screening
    • Subcommittee on Cystic Fibrosis Screening, Accreditation of Genetic Services Committee, ACMG. American College of Medical Genetics
    • Grody WW, Cutting GR, Klinger KW, Richards CS, Watson MS, Desnick RJ; Subcommittee on Cystic Fibrosis Screening, Accreditation of Genetic Services Committee, ACMG. American College of Medical Genetics. Laboratory standards and guidelines for population-based cystic fibrosis carrier screening. Genet Med. 2001;3(2):149-154
    • (2001) Genet Med , vol.3 , Issue.2 , pp. 149-154
    • Grody, W.W.1    Cutting, G.R.2    Klinger, K.W.3    Richards, C.S.4    Watson, M.S.5    Desnick, R.J.6
  • 23
    • 0942285246 scopus 로고    scopus 로고
    • Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: A cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections
    • DOI 10.1542/peds.113.6.1573
    • Comeau AM, Parad RB, Dorkin HL, et al. Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: a cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections. Pediatrics. 2004;113(6):1573-1581 (Pubitemid 38697961)
    • (2004) Pediatrics , vol.113 , Issue.6 I , pp. 1573-1581
    • Comeau, A.M.1    Parad, R.B.2    Dorkin, H.L.3    Dovey, M.4    Gerstle, R.5    Haver, K.6    Lapey, A.7    O'Sullivan, B.P.8    Waltz, D.A.9    Zwerdling, R.G.10    Eaton, R.B.11
  • 25
    • 35349017871 scopus 로고    scopus 로고
    • Diagnosis of cystic fibrosis in the Republic of Ireland: Epidemiology and costs
    • Farrell PM, Joffe S, Foley L, Canny GJ, Mayne P, Rosenberg M. Diagnosis of cystic fibrosis in the Republic of Ireland: epidemiology and costs. Ir Med J. 2007;100(8):557-560
    • (2007) Ir Med J , vol.100 , Issue.8 , pp. 557-560
    • Farrell, P.M.1    Joffe, S.2    Foley, L.3    Canny, G.J.4    Mayne, P.5    Rosenberg, M.6
  • 26
    • 25844520151 scopus 로고    scopus 로고
    • Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: Screening efficacy and diagnostic outcomes
    • DOI 10.1016/j.jpeds.2005.08.005, PII S002234760500750X
    • Sontag MK, Hammond KB, Zielenski J, Wagener JS, Accurso FJ. Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: screening efficacy and diagnostic outcomes. J Pediatr. 2005;147(suppl 3):S83-S88 (Pubitemid 41400265)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Sontag, M.K.1    Hammond, K.B.2    Zielenski, J.3    Wagener, J.S.4    Accurso, F.J.5
  • 27
    • 0025936890 scopus 로고
    • Efficacy of statewide neonatal screening for cystic fibrosis by assay of trypsinogen concentrations
    • Hammond KB, Abman SH, Sokol RJ, Accurso FJ. Efficacy of statewide neonatal screening for cystic fibrosis by assay of trypsinogen concentrations. N Engl J Med. 1991;325(11):769-774
    • (1991) N Engl J Med , vol.325 , Issue.11 , pp. 769-774
    • Hammond, K.B.1    Abman, S.H.2    Sokol, R.J.3    Accurso, F.J.4
  • 29
    • 0026294613 scopus 로고
    • Laboratory quality control issues related to screening newborns for cystic fibrosis using immunoreactive trypsin
    • Hassemer DJ, Laessig RH, Hoffman GL, Farrell PM. Laboratory quality control issues related to screening newborns for cystic fibrosis using immunoreactive trypsin. Pediatr Pulmonol Suppl. 1991;7:76-83
    • (1991) Pediatr Pulmonol Suppl , vol.7 , pp. 76-83
    • Hassemer, D.J.1    Laessig, R.H.2    Hoffman, G.L.3    Farrell, P.M.4
  • 30
    • 0029558007 scopus 로고
    • Neonatal screening for cystic fibrosis: A comparison of two strategies for case detection in 1.2 million babies
    • DOI 10.1016/S0022-3476(95)70040-4
    • Wilcken B, Wiley V, Sherry G, Bayliss U. Neonatal screening for cystic fibrosis: a comparison of two strategies for case detection in 1.2 million babies. J Pediatr. 1995;127(6):965-970 (Pubitemid 26003294)
    • (1995) Journal of Pediatrics , vol.127 , Issue.6 , pp. 965-970
    • Wilcken, B.1    Wiley, V.2    Sherry, G.3    Bayliss, U.4
  • 31
    • 0025281614 scopus 로고
    • Newborn screening for cystic fibrosis is complicated by age-related decline in immunoreactive trypsinogen levels
    • Rock MJ, Mischler EH, Farrell PM, et al. Newborn screening for cystic fibrosis is complicated by age-related decline in immunoreactive trypsinogen levels. Pediatrics. 1990;85(6):1001-1007 (Pubitemid 20184720)
    • (1990) Pediatrics , vol.85 , Issue.6 , pp. 1001-1007
    • Rock, M.J.1    Mischler, E.H.2    Farrell, P.M.3    Wei, L.-J.4    Bruns, W.T.5    Hassemer, D.J.6    Laessig, R.H.7
  • 33
    • 0942285246 scopus 로고    scopus 로고
    • Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: A cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections
    • DOI 10.1542/peds.113.6.1573
    • Comeau AM, Parad RB, Dorkin HL, et al. Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: a cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections. Pediatrics. 2004;113(6):1573-1581 (Pubitemid 38697961)
    • (2004) Pediatrics , vol.113 , Issue.6 I , pp. 1573-1581
    • Comeau, A.M.1    Parad, R.B.2    Dorkin, H.L.3    Dovey, M.4    Gerstle, R.5    Haver, K.6    Lapey, A.7    O'Sullivan, B.P.8    Waltz, D.A.9    Zwerdling, R.G.10    Eaton, R.B.11
  • 36
    • 25844459441 scopus 로고    scopus 로고
    • Communications systems and their models: Massachusetts parent compliance with recommended specialty care after positive cystic fibrosis newborn screening result
    • DOI 10.1016/j.jpeds.2005.08.007, PII S0022347605007523
    • Comeau AM, Parad R, Gerstle R, et al. Communications systems and their models: Massachusetts parent compliance with recommended specialty care after positive cystic fibrosis newborn screening result. J Pediatr. 2005;147(suppl 3):S98-S100 (Pubitemid 41400268)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Comeau, A.M.1    Parad, R.2    Gerstle, R.3    O'Sullivan, B.P.4    Dorkin, H.L.5    Dovey, M.6    Haver, K.7    Martin, T.8    Eaton, R.B.9
  • 37
    • 0034565196 scopus 로고    scopus 로고
    • Improving the health of patients with cystic fibrosis through newborn screening
    • Wisconsin Cystic Fibrosis Neonatal Screening Study Group
    • Farrell PM. Improving the health of patients with cystic fibrosis through newborn screening. Wisconsin Cystic Fibrosis Neonatal Screening Study Group. Adv Pediatr. 2000;47:79-115
    • (2000) Adv Pediatr , vol.47 , pp. 79-115
    • Farrell, P.M.1
  • 38
    • 25844445259 scopus 로고    scopus 로고
    • Newborn screening for cystic fibrosis in Wisconsin: Nine-year experience with routine trypsinogen/DNA testing
    • DOI 10.1016/j.jpeds.2005.08.004, PII S0022347605007493
    • Rock MJ, Hoffman G, Laessig RH, Kopish GJ, Litsheim TJ, Farrell PM. Newborn screening for cystic fibrosis in Wisconsin: nine-year experience with routine trypsinogen/DNA testing. J Pediatr. 2005;147(suppl 3):S73-S77 (Pubitemid 41400263)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Rock, M.J.1    Hoffman, G.2    Laessig, R.H.3    Kopish, G.J.4    Litsheim, T.J.5    Farrell, P.M.6
  • 39
    • 33846924392 scopus 로고    scopus 로고
    • The meaning of "early" diagnosis in a new era of cystic fibrosis care
    • DOI 10.1542/peds.2006-3074
    • Farrell PM. The meaning of "early" diagnosis in a new era of cystic fibrosis care. Pediatrics. 2007;119(1):156-157 (Pubitemid 46397858)
    • (2007) Pediatrics , vol.119 , Issue.1 , pp. 156-157
    • Farrell, P.M.1
  • 40
    • 0026026265 scopus 로고
    • Neonatal screening for cystic fibrosis in Wales and the West Midlands: Clinical assessment after five years of screening
    • Chatfield S, Owen G, Ryley HC, et al. Neonatal screening for cystic fibrosis in Wales and the West Midlands: clinical assessment after five years of screening. Arch Dis Child. 1991;66(1 Spec No):29-33
    • (1991) Arch Dis Child , vol.66 , Issue.1 SPEC NO , pp. 29-33
    • Chatfield, S.1    Owen, G.2    Ryley, H.C.3
  • 41
    • 17744372496 scopus 로고    scopus 로고
    • Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth
    • DOI 10.1542/peds.107.1.1
    • Farrell PM, Kosorok MR, Rock MJ, et al Wisconsin Cystic Fibrosis Neonatal Screening Study Group. Early diagnosis of cystic fibrosis through neonatal screening prevents severe malnutrition and improves long-term growth. Pediatrics. 2001;107(1):1-13 (Pubitemid 32055408)
    • (2001) Pediatrics , vol.107 , Issue.1 , pp. 1-13
    • Farrell, P.M.1    Kosorok, M.R.2    Rock, M.J.3    Laxova, A.4    Zeng, L.5    Lai, H.-C.6    Hoffman, G.7    Laessig, R.H.8    Splaingard, M.L.9
  • 42
    • 25844493613 scopus 로고    scopus 로고
    • Overview of published evidence on outcomes with early diagnosis from large US observational studies
    • DOI 10.1016/j.jpeds.2005.08.010, PII S0022347605007559
    • Rosenfeld M. Overview of published evidence on outcomes with early diagnosis from large US observational studies. J Pediatr. 2005;147(suppl 3):S11-S14 (Pubitemid 41400252)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Rosenfeld, M.1
  • 44
    • 25844466580 scopus 로고    scopus 로고
    • The survival advantage of patients with cystic fibrosis diagnosed through neonatal screening: Evidence from the United States cystic fibrosis Foundation Registry data
    • DOI 10.1016/j.jpeds.2005.08.014, PII S0022347605007596
    • Lai HJ, Cheng Y, Farrell PM. The survival advantage of patients with cystic fibrosis diagnosed through neonatal screening: evidence from the United States Cystic Fibrosis Foundation registry data. J Pediatr. 2005;147(suppl 3):S57-S63 (Pubitemid 41400260)
    • (2005) Journal of Pediatrics , vol.147 , Issue.3 SUPPL.
    • Lai, H.J.1    Cheng, Y.2    Farrell, P.M.3
  • 46
    • 33748153791 scopus 로고    scopus 로고
    • Potential impact of newborn screening for cystic fibrosis on child survival: A systematic review and analysis
    • DOI 10.1016/j.jpeds.2006.04.059, PII S0022347606003878
    • Grosse SD, Rosenfeld M, Devine OJ, Lai HJ, Farrell PM. Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysis. J Pediatr. 2006;149(3):362-366 (Pubitemid 44308429)
    • (2006) Journal of Pediatrics , vol.149 , Issue.3 , pp. 362-366
    • Grosse, S.D.1    Rosenfeld, M.2    Devine, O.J.3    Lai, H.J.4    Farrell, P.M.5
  • 47
    • 78449312275 scopus 로고    scopus 로고
    • The need for quality improvement in sweat testing infants after newborn screening for cystic fibrosis
    • Legrys VA, McColley SA, Li Z, Farrell PM. The need for quality improvement in sweat testing infants after newborn screening for cystic fibrosis. J Pediatr. 2010;157(6):1035-1037
    • (2010) J Pediatr , vol.157 , Issue.6 , pp. 1035-1037
    • Legrys, V.A.1    McColley, S.A.2    Li, Z.3    Farrell, P.M.4
  • 48
    • 79958244519 scopus 로고    scopus 로고
    • Optimal DNA tier for the IRT/DNA algorithm determined by CFTR mutation results over 14 years of newborn screening
    • Baker MW, Groose M, Hoffman G, Rock M, Levy H, Farrell PM. Optimal DNA tier for the IRT/DNA algorithm determined by CFTR mutation results over 14 years of newborn screening. J Cyst Fibros. 2011;10(4):278-281
    • (2011) J Cyst Fibros , vol.10 , Issue.4 , pp. 278-281
    • Baker, M.W.1    Groose, M.2    Hoffman, G.3    Rock, M.4    Levy, H.5    Farrell, P.M.6
  • 49
    • 0024386077 scopus 로고
    • A prospective randomized trial of early diagnosis and treatment of cystic fibrosis: A unique ethical dilemma
    • Fost N, Farrell PM. A prospective randomized trial of early diagnosis and treatment of cystic fibrosis: a unique ethical dilemma. Clin Res. 1989;37(3):495-500 (Pubitemid 19214804)
    • (1989) Clinical Research , vol.37 , Issue.3 , pp. 495-500
    • Fost, N.1    Farrell, P.M.2


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