Adverse drug events in intensive care units: A cross-sectional study of prevalence and risk factors

American Journal of Critical Care

Volumn 20, Issue 6, 2011, Pages

  Seynaeve, Simon ^a   Verbrugghe, Walter ^a   Claes, Brigitte ^a   Vandenplas, Dirk ^a   Reyntiens, Dirk ^a   Jorens, Philippe G ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BELGIUM; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; DRUG TOXICITY; ECONOMICS; FEMALE; HEALTH CARE QUALITY; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MALE; MIDDLE AGED; NURSING CARE; RISK FACTOR; STATISTICAL MODEL; WORKLOAD;

ADULT; AGED; AGED, 80 AND OVER; BELGIUM; CROSS-SECTIONAL STUDIES; DRUG TOXICITY; FEMALE; HUMANS; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; NURSING CARE; QUALITY OF HEALTH CARE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; WORKLOAD;

EID: 84856517145     PISSN: 10623264     EISSN: None     Source Type: Journal    
DOI: 10.4037/ajcc2011818     Document Type: Article

References (33)

1. Stump LS. Re-engineering the medication error-reporting process: removing the blame and improving the system. Am J Health Syst Pharm. 2000;57(suppl 4):S10-S17.
2. Kane-Gill SL, Jacobi J, Rothschild JM. Adverse drug events in intensive care units: risk factors, impact, and the role of team care. Crit Care Med. 2010;38(6 suppl):S83-S89.
3. Bates DW, Spell N, Cullen DJ, et al; Adverse Drug Events Prevention Study Group. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277(4):307-311.
4. Nebeker JR, Barach P, Samore MH. Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting. Ann Intern Med. 2004;140(10):795-801.
5. Rothschild JM, Landrigan CP, Cronin JW, et al. The Critical Care Safety Study: the incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med. 2005;33(8):1694-1700.
6. Shamliyan TA, Duval S, Du J, Kane RL. Just what the doctor ordered: review of the evidence of the impact of computerized physician order entry system on medication errors. Health Serv Res. 2008;43(1 pt 1):32-53.
7. Rozich JD, Haraden CR, Resar RK. Adverse drug event trigger tool: a practical methodology for measuring medication related harm. Qual Saf Health Care. 2003;12(3):194-200.
8. Classen DC, Pestotnik SL, Evans RS, Burke JP. Computerized surveillance of adverse drug events in hospital patients. JAMA. 1991;266(20):2847-2851.
9. Griffin FA, Resar RK. IHI Global Trigger Tool for Measuring Adverse Events. IHI innovation series white paper. Cambridge, MA: Institute for Healthcare Improvement; 2007.
10. National Coordinating Council for Medication Error Reporting and Prevention. Taxonomy of medication errors. 2001. http://www.nccmerp.org/pdf/indexBW2001-06-12.pdf.
11. Knaus WA, Zimmerman JE, Wagner DP, Draper EA, Lawrence DE. APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med. 1981;9(8):591-597.
12. Vincent JL, Moreno R, Takala J, et al; on behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/ failure. Intensive Care Med. 1996;22(7):707-710.
13. Miranda DR, de Rijk A, Schaufeli W. Simplified Therapeutic Intervention Scoring System: the TISS-28 items-results from a multicenter study. Crit Care Med. 1996;24(1):64-73.
14. Moreno R, Morais P. Validation of the Simplified Therapeutic Intervention Scoring System on an independent database. Intensive Care Med. 1997;23(6):640-644.
15. Jakob SM, Rothen HU. Intensive care 1980-1995: change in patient characteristics, nursing workload and outcome. Intensive Care Med. 1997;23(11):1165-1170.
16. Cullen DJ, Bates DW, Leape LL. Prevention of adverse drug events: a decade of progress in patient safety. J Clin Anesth. 2000;12(8):600-614.
17. Valentin A, Capuzzo M, Guidet B, et al. Patient safety in intensive care: results from the multinational Sentinel Events Evaluation (SEE) study. Intensive Care Med. 2006;32(10): 1591-1598.
18. Resar RK, Rozich JD, Simmonds T, Haraden CR. A trigger tool to identify adverse events in the intensive care unit. Jt Comm J Qual Patient Saf. 2006;32(10):585-590.
19. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359-1367.
20. De Block C, Manuel-y-Keenoy B, Rogiers P, Jorens P, Van Gaal L. Glucose control and use of continuous glucose monitoring in the intensive care unit: a critical review. Curr Diabetes Rev. 2008;4(3):234-244.
21. Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283-1297.
22. Vriesendorp TM, van Santen S, DeVries JH, et al. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med. 2006;34(1):96-101.
23. Azevedo JR, Lima ER, Cossetti RJ, Azevedo RP. Intensive insulin therapy versus conventional glycemic control in patients with acute neurological injury: a prospective controlled trial. Arq Neuropsiquiatr. 2007;65(3B):733-738.
24. Kanjanarat P, Winterstein AG, Johns TE, Hatton RC, Gonzalez- Rothi R, Segal R. Nature of preventable adverse drug events in hospitals: a literature review. Am J Health Syst Pharm. 2003;60(17):1750-1759.
25. Grenouillet-Delacre M, Verdoux H, Moore N, et al. Lifethreatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital. Intensive Care Med. 2007;33(12):2150-2157.
26. Giraud T, Dhainaut JF, Vaxelaire JF, et al. Iatrogenic complications in adult intensive care units: a prospective twocenter study. Crit Care Med. 1993;21(1):40-51.
27. Valentin A, Capuzzo M, Guidet B, et al; Research Group on Quality Improvement of the European Society of Intensive Care Medicine (ESICM); Sentinel Events Evaluation (SEE) Study Investigators. Errors in administration of parenteral drugs in intensive care units: multinational prospective study. BMJ. 2009;338:b814.
28. Aragon D. Evaluation of nursing work effort and perceptions about blood glucose testing in tight glycemic control. Am J Crit Care. 2006;15(4):370-377.
29. West E, Mays N, Rafferty AM, Rowan K, Sanderson C. Nursing resources and patient outcomes in intensive care: a systematic review of the literature. Int J Nurs Stud. 2009; 46(7):993-1011.
30. Amaravadi RK, Dimick JB, Pronovost PJ, Lipsett PA. ICU nurse-to-patient ratio is associated with complications and resource use after esophagectomy. Intensive Care Med. 2000;26(12):1857-1862.
31. Thorens JB, Kaelin RM, Jolliet P, Chevrolet JC. Influence of the quality of nursing on the duration of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med. 1995;23(11):1807-1815.
32. Pronovost PJ, Jenckes MW, Dorman T, et al. Organizational characteristics of intensive care units related to outcomes of abdominal aortic surgery. JAMA. 1999;281(14):1310-1317.
33. Aiken LH, Clarke SP, Sloane DM, Sochalski J, Silber JH. Hospital nurse staffing and patient mortality, nurse burnout, and job dissatisfaction. JAMA. 2002;288(16):1987-1993.