Pretransplant immune regulation predicts allograft outcome: Bidirectional regulation correlates with excellent renal transplant function in living-related donor-recipient pairs

Transplantation

Volumn 93, Issue 3, 2012, Pages 283-290

  Jankowska Gan, Ewa ^a   Sheka, Adam ^a   Sollinger, Hans W ^a   Pirsch, John D ^a   Hofmann, R Michael ^a   Haynes, Lynn D ^a   Armbrust, Michael J ^a   Mezrich, Joshua D ^a   Burlingham, William J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Indirect pathway; Kidney transplantation; Prediction of outcome; Pretransplant bidirectional regulation

Indexed keywords

ALEMTUZUMAB; BASILIXIMAB; CREATININE; HLA ANTIGEN; RITUXIMAB;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DONOR SELECTION; FEMALE; GRAFT FAILURE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERSENSITIVITY; IMMUNE STATUS; IMMUNOREGULATION; IN VIVO STUDY; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVING DONOR; MALE; MONOCYTE; OUTCOME ASSESSMENT; PERIPHERAL BLOOD MONOCYTE CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTION; PRIORITY JOURNAL;

ADULT; ANIMALS; FEMALE; GLOMERULAR FILTRATION RATE; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HUMANS; IMMUNE TOLERANCE; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; MICE; MICE, SCID; MIDDLE AGED; SIBLINGS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84856483844     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31823e46a0     Document Type: Article

References (34)

1. Owen RD, Wood HR, Foord AG, et al. Evidence for actively acquired tolerance to Rh antigens. Proc Natl Acad Sci USA 1954; 40: 420.
2. Claas FH, Gijbels Y, van Der Velden-de Munck J, et al. Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science 1988; 241: 1815.
3. Burlingham WJ, Grailer AP, Heisey DM, et al. The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors. N Engl J Med 1998; 339: 1657.
4. Ichinohe T, Uchiyama T, Shimazaki C, et al. Feasibility of HLAhaploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism. Blood 2004; 104: 3821.
5. van Rood JJ, Loberiza FR Jr, Zhang MJ, et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLAhaploidentical sibling. Blood 2002; 99: 1572.
6. Opelz G, Study FTCT. Analysis of the 'NIMA effect' in renal transplantation. In: Terasaki PI, ed. Clinical transplantation. Los Angeles, CA, UCLA Tissue Typing Laboratory 1990, pp 63.
7. Miles CD, Schaubel DE, Liu D, et al. The role of donor-recipient relationship in long-term outcomes of living donor renal transplantation. Transplantation 2008; 85: 1483.
8. van Halteren AG, Jankowska-Gan E, Joosten A, et al. Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood 2009; 114: 2263.
9. Cai J, Lee J, Jankowska-Gan E, et al. Minor H antigen HA-1-specific regulator and effector CD8- T cells, and HA-1 microchimerism, in allograft tolerance. J Exp Med 2004; 199: 1017.
10. Dutta P, Dart M, Roenneburg DA, et al. Pretransplant immuneregulation predicts allograft tolerance. Am J Transplant 2011; 11: 1296.
11. HaynesLD,Jankowska-Gan E, Sheka A, et al. Donor-specific indirect pathway analysis reveals aBcell-independent signature which reflects outcomes in kidney transplant recipients.AmJ Transplant 2011; [published onlineaheadof print December 7, 2011] doi:10.1111/j.1600-6143.2011.03869.x.
12. Mold JE, Michaelsson J, Burt TD, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008; 322: 1562.
13. Hadley GA, Phelan DL, Duffy BF, et al. Lack of T-cell tolerance of noninherited maternal HLA antigens in normal humans. Hum Immunol 1990; 28: 373.
14. Roelen DL, van Bree FP, van Beelen E, et al. No evidence of an influence of the non-inherited maternal HLA antigens on the alloreactive T cell repertoire in healthy individuals. Transplantation 1995; 59: 1728.
15. van den Boogaardt DE, van Miert PP, Koekkoek KM, et al. No in vitro evidence for a decreased alloreactivity toward noninherited maternal HLA antigens in healthy individuals. Hum Immunol 2005; 66: 1203.
16. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance [see comments]. Hepatology 1993; 17: 1127.
17. Starzl TE, Demetris AJ, Trucco M, et al. Systemic chimerism in human female recipients of male livers. Lancet 1992; 340: 876.
18. Wood KJ, Sachs DH. Chimerism and transplantation tolerance: Cause and effect. Immunol Today 1998; 17: 584.
19. Burlingham WJ, Grailer AP, Fechner JHJ, et al. Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 1995; 59: 1147.
20. Ko S, Deiwick A, Jager MD, et al. The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. Nat Med 1999; 5: 1292.
21. Bishop GA, Sun J, Sheil AG, et al. High-dose/activation-associated tolerance: Amechanism for allograft tolerance. Transplantation 1997; 64: 1377.
22. Torrealba JR, Katayama M, Fechner JH Jr, et al. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1-CD4- T regulatory cell infiltrates. J Immunol 2004; 172: 5753.
23. Xu Q, Lee J, Jankowska-Gan E, et al. Human CD4-CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 2007; 178: 3983.
24. WangC,CordobaS,HuM,et al. Spontaneous acceptance ofmousekidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transpl Immunol 2011; 24: 149.
25. Lafferty KJ, Cooley MA, Woolnough J, et al. Thyroid allograft immunogenicity is reduced after a period in organ culture. Science 1975; 188: 259.
26. Lechler RI, Batchelor JR. Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient. J Exp Med 1982; 156: 1835.
27. Chan WF, Perez-Diez A, Razavy H, et al. The ability of natural tolerance to be applied to allogeneic tissue: Determinants and limits. Biol Direct 2007; 2: 10.
28. Mezrich JD, Yamada K, Lee RS, et al. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation 2003; 76: 625.
29. Steinmuller D. Immunization with skin isografts taken from tolerant mice. Science 1967; 158: 127.
30. Rosengard BR, Kortz EO, Guzzetta PC, et al. Transplantation in miniature swine: Analysis of graft-infiltrating lymphocytes provides evidence for local suppression. Hum Immunol 1990; 28: 153.
31. Mathew JM, Ciancio G, Burke GW, et al. Immune "tolerance profiles" in donor bone marrow infused kidney transplant patients using multiple ex vivo functional assays. Hum Immunol 2010; 71: 566.
32. Molitor-Dart ML, Andrassy J, Haynes LD, et al. Tolerance induction or sensitization in mice exposed to noninherited maternal antigens (NIMA). Am J Transplant 2008; 8: 2307.
33. Burlingham WJ, Jankowska-Gan E. Mouse strain and injection site are crucial for detecting linked suppression in transplant recipients by trans-vivo DTH assay. Am J Transplant 2007; 7: 466.
34. VanBuskirk AM, Burlingham WJ, Jankowska-Gan E, et al. Human allograft acceptance is associated with immune regulation. J Clin Invest 2000; 106: 145.