Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1

Journal of Allergy and Clinical Immunology

Volumn 129, Issue 2, 2012, Pages

  Pedroza, Luis A ^a,b,c   Kumar, Vipul ^b   Sanborn, Keri B ^b,d   MacE, Emily M ^b   Niinikoski, Harri ^e   Nadeau, Kari ^f   De Moraes Vasconcelos, Dewton ^c   Perez, Elena ^g   Jyonouchi, Soma ^b   Jyonouchi, Harumi ^h   Banerjee, Pinaki P ^b   Ruuskanen, Olli ^e   Condino Neto, Antonio ^c   Orange, Jordan S ^b,d  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

^h RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

chronic mucocutaneous candidiasis; innate immunity; monocytes; Primary immunodeficiency

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; BETA GLUCAN; CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECUITMENT DOMAIN PROTEIN 9; DECTIN 1; PROTEIN KINASE SYK; RAF PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; AUTOIMMUNITY; CANDIDA; CANDIDIASIS; CELL MEMBRANE; CELL PROLIFERATION; CELL SELECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; INNATE IMMUNITY; MOLECULAR RECOGNITION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 84856481340     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.08.027     Document Type: Article

References (37)

1. Finnish-German APECED Consortium An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains Nat Genet 17 1997 399 403
2. D. Mathis, and C. Benoist Aire Annu Rev Immunol 27 2009 287 312
3. K. Kisand, A.S. Boe Wolff, K.T. Podkrajsek, L. Tserel, M. Link, and K.V. Kisand Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines J Exp Med 207 2010 299 308
4. A. Puel, R. Doffinger, A. Natividad, M. Chrabieh, G. Barcenas-Morales, and C. Picard Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I J Exp Med 207 2010 291 297
5. K. Kogawa, S. Nagafuchi, H. Katsuta, J. Kudoh, S. Tamiya, and Y. Sakai Expression of AIRE gene in peripheral monocyte/dendritic cell lineage Immunol Lett 80 2002 195 198
6. M.G. Netea, G.D. Brown, B.J. Kullberg, and N.A. Gow An integrated model of the recognition of Candida albicans by the innate immune system Nat Rev Microbiol 6 2008 67 78
7. H.S. Goodridge, C.N. Reyes, C.A. Becker, T.R. Katsumoto, J. Ma, and A.J. Wolf Activation of the innate immune receptor Dectin-1 upon formation of a "phagocytic synapse." Nature 472 2011 471 475
8. S. LeibundGut-Landmann, O. Gross, M.J. Robinson, F. Osorio, E.C. Slack, and S.V. Tsoni Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 Nat Immunol 8 2007 630 638
9. B. Ferwerda, G. Ferwerda, T.S. Plantinga, J.A. Willment, A.B. van Spriel, and H. Venselaar Human dectin-1 deficiency and mucocutaneous fungal infections N Engl J Med 361 2009 1760 1767
10. E.O. Glocker, A. Hennigs, M. Nabavi, A.A. Schaffer, C. Woellner, and U. Salzer A homozygous CARD9 mutation in a family with susceptibility to fungal infections N Engl J Med 361 2009 1727 1735
11. S.I. Gringhuis, J. den Dunnen, M. Litjens, M. van der Vlist, B. Wevers, and S.C. Bruijns Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk Nat Immunol 10 2009 203 213
12. J. Brannstrom, S. Hassler, L. Peltonen, B. Herrmann, and O. Winqvist Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens Clin Immunol 121 2006 265 273
13. N. Pontynen, M. Strengell, N. Sillanpaa, J. Saharinen, I. Ulmanen, and I. Julkunen Critical immunological pathways are downregulated in APECED patient dendritic cells J Mol Med 86 2008 1139 1152
14. B.J. Ferguson, C. Alexander, S.W. Rossi, I. Liiv, A. Rebane, and C.L. Worth AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity J Biol Chem 283 2008 1723 1731
15. J. Pitkanen, P. Vahamurto, K. Krohn, and P. Peterson Subcellular localization of the autoimmune regulator protein. characterization of nuclear targeting and transcriptional activation domain J Biol Chem 276 2001 19597 19602
16. R.D. Bhui, D.B. Lewis, and K.C. Nadeau A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy Ann Allergy Asthma Immunol 100 2008 169
17. A. Condino-Neto, and P.E. Newburger Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation Blood 95 2000 3548 3554
18. R.P. Deering, and J.S. Orange Development of a clinical assay to evaluate toll-like receptor function Clin Vaccine Immunol 13 2006 68 76
19. P.P. Banerjee, R. Pandey, R. Zheng, M.M. Suhoski, L. Monaco-Shawver, and J.S. Orange Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse J Exp Med 204 2007 2305 2320
20. K.B. Sanborn, G.D. Rak, S.Y. Maru, K. Demers, A. Difeo, and J.A. Martignetti Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse J Immunol 182 2009 6969 6984
21. G. Ferwerda, F. Meyer-Wentrup, B.J. Kullberg, M.G. Netea, and G.J. Adema Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages Cell Microbiol 10 2008 2058 2066
22. J.W. Hovius, M.A. de Jong, J. den Dunnen, M. Litjens, E. Fikrig, and T. van der Poll Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization PLoS Pathog 4 2008 e31
23. O. Gross, A. Gewies, K. Finger, M. Schafer, T. Sparwasser, and C. Peschel Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity Nature 442 2006 651 656
24. K.M. Dennehy, G. Ferwerda, I. Faro-Trindade, E. Pyz, J.A. Willment, and P.R. Taylor Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors Eur J Immunol 38 2008 500 506
25. L. Carsetti, L. Laurenti, S. Gobessi, P.G. Longo, G. Leone, and D.G. Efremov Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation Cell Signal 21 2009 1187 1194
26. K. Kogawa, J. Kudoh, S. Nagafuchi, S. Ohga, H. Katsuta, and H. Ishibashi Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations Clin Immunol 103 2002 277 283
27. T. Reimann, D. Buscher, R.A. Hipskind, S. Krautwald, M.L. Lohmann-Matthes, and M. Baccarini Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes J Immunol 153 1994 5740 5749
28. J. den Dunnen, S.I. Gringhuis, and T.B. Geijtenbeek Innate signaling by the C-type lectin DC-SIGN dictates immune responses Cancer Immunol Immunother 58 2009 1149 1157
29. V. Kumar, L.A. Pedroza, E.M. Mace, S. Seeholzer, G. Cotsarelis, and A. Condino-Neto The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17 Am J Pathol 178 2011 983 988
30. J. Abramson, M. Giraud, C. Benoist, and D. Mathis Aire's partners in the molecular control of immunological tolerance Cell 140 2010 123 135
31. J. Pitkanen, V. Doucas, T. Sternsdorf, T. Nakajima, S. Aratani, and K. Jensen The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein J Biol Chem 275 2000 16802 16809
32. J.P. Ting, and B.K. Davis CATERPILLER: a novel gene family important in immunity, cell death, and diseases Annu Rev Immunol 23 2005 387 414
33. K.A. Porter, L.N. Kelley, A. George, J.A. Harton, and K.M. Duus Class II transactivator (CIITA) enhances cytoplasmic processing of HIV-1 Pr55Gag PLoS One 5 2010 e11304
34. M.J. Robinson, F. Osorio, M. Rosas, R.P. Freitas, E. Schweighoffer, and O. Gross Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection J Exp Med 206 2009 2037 2051
35. S. Saijo, S. Ikeda, K. Yamabe, S. Kakuta, H. Ishigame, and A. Akitsu Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans Immunity 32 2010 681 691
36. S. Agrawal, S. Gupta, and A. Agrawal Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses PLoS One 5 2010 e13418
37. L. Ni, I. Gayet, S. Zurawski, D. Duluc, A.L. Flamar, and X.H. Li Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses J Immunol 185 2010 3504 3513