Long pentraxin 3 (PTX3) in the light of its structure, mechanism of action and clinical implications

Autoimmunity

Volumn 45, Issue 2, 2012, Pages 119-128

  Cieślik, Paweł ^a   Hrycek, Antoni ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Clinical implications; Mechanisms of action; Pentraxin 3; Structure; Synthesis

Indexed keywords

ASPARAGINE; CD40 LIGAND; COMPLEMENT COMPONENT C1Q; COMPLEMENT FACTOR H; CYSTEINE; FIBROBLAST GROWTH FACTOR 2; FICOLIN 1; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MANNOSE BINDING LECTIN; OPSONIN; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PENTRAXIN 3; PROSTAGLANDIN E2; PROTEIN; THROMBOSPONDIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PEA3; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 6; UNCLASSIFIED DRUG; ZYMOSAN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANGIOGENESIS; APOPTOSIS; ARTICLE; ASPERGILLUS FUMIGATUS; ATHEROSCLEROSIS; AUTOIMMUNITY; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CARDIOVASCULAR RISK; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME 3Q; COMPLEMENT LECTIN PATHWAY; COVALENT BOND; CROSS PRESENTATION; CYTOKINE RELEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; DISULFIDE BOND; DNA POLYMORPHISM; EXON; EXTRACELLULAR MATRIX; FEMALE FERTILITY; GENETIC ASSOCIATION; GLYCOSYLATION; HEART; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE; MOLECULAR WEIGHT; MONOCYTE; MYELOID DENDRITIC CELL; NEISSERIA MENINGITIDIS; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS; PERITONEUM MACROPHAGE; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; RESTENOSIS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; UPREGULATION; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

ANIMALS; C-REACTIVE PROTEIN; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LIGANDS; SERUM AMYLOID P-COMPONENT;

EID: 84856470326     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2011.611549     Document Type: Article

References (37)

1. Bottazzi B, Bastone A, Doni A, Garlanda C, Valentino S, Deban L, Maina V, Cotena A, Moalli F, Vago L, Salustri A, Romani L, Mantovani A. The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. Leukoc Biol 2006;79:909-912. (Pubitemid 44835576)
2. Bozza S, Bistoni F, Gaziano R, Pitzurra L, Zelante T, Bonifazi P, Perruccio K, Bellocchio S, Neri M, Iorio AM, Salvatori G, De Santis R, Calvitti M, Doni A, Garlanda C, Mantovani A, Romani L. Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation. Blood 2006;108:3387-3396.
3. Kunes? P, Lonský V, Mand'ák J, Brtko M, Kolácková M, Andrýs C, Kudlová M, Krejsek J. Essential PTX3 biology (not only) for cardiologists and cardiac surgeons. Acta Medica (Hradec Králové) 2007;50:29-33.
4. Presta M, Camozzi M, Salvatori G, Rusnati M. Role of the soluble pattern recognition receptor PTX3 in vascular biology. J Cell Mol Med 2007;4:723-738. (Pubitemid 47313297)
5. Rusnati M, Camozzi M, Moroni E, Bottazzi B, Peri G, Indraccolo S, Amadori A, Mantovani A, Presta M. Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis. Blood 2004;104:92-99. (Pubitemid 38879843)
6. Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G. Long pentraxin 3: A marker of inflammation in untreated psoriatic patients. Int J Mol Med 2006;18:415-423.
7. Kravitz MS, Shoenfeld Y. Autoimmunity to protective molecules: Is it the perpetuum mobile (vicious cycle) of autoimmune rheumatic diseases? Nat Clin Pract Rheumatol 2006 9 481-490. (Pubitemid 44340424)
8. Rovere P, Peri G, Fazzini F, Bottazzi B, Doni A, Bondanza A, Zimmermann VS, Garlanda C, Fascio U, Sabbadini MG, Rugarli C, Mantovani A, Manfredi AA. The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells. Blood 2000;96:4300-4306.
9. van Rossum AP, Pas HH, Fazzini F, Huitema MG, Limburg PC, Jonkman MF, Kallenberg CG. Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis. Arthritis Rheum 2006;54: 986-991.
10. Ortega-Hernandez OD, Bassi N, Shoenfeld Y, Anaya JM. The long pentraxin 3 and its role in autoimmunity. Semin Arthritis Rheum 2009;39:38-54.
11. Inforzato A, Jaillon S, Moalli F, Barbati E, Bonavita E, Bottazzi B, Mantovani A, Garlanda C. The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. Tissue Antigens 2011;77:271-282.
12. Fazzini F, Peri G, Doni A, Dell'Antonio G, Dal Cin E, Bozzolo E, D'Auria F, Praderio L, Ciboddo G, Sabbadini MG, Manfredi AA, Mantovani A, Querini PR. PTX3 in small-vessel vasculitides. Arthritis Rheum 2001;44:2841-2850.
13. Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol 2010;11:328-334.
14. Nebuloni M, Pasqualini F, Zerbi P, Lauri E, Mantovani A, Vago L, Garlanda C. PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis. Cardiovasc Pathol 2011;20:e27-35, Available: Doi:10.1016/ j.carpath.2010.02.005 via the INTERNET.
15. Jaillon S, Peri G, Delneste Y, Frémaux I, Doni A, Moalli F, Garlanda C, Romani L, Gascan H, Bellocchio S, Bozza S, Cassatella MA, Jeannin P, Mantovani A. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 2007;204: 793-804. (Pubitemid 46631609)
16. Luchetti MM, Piccinini G, Mantovani A, PeriG, Matteucci C, Pomponio G, Fratini M, Fraticelli P, Sambo P, Di Loreto C, Doni A, Introna M, Gabrielli A. Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA). Clin Exp Immunol 2000;119:196-202. (Pubitemid 30064610)
17. Bosutti A, Grassi G, Zanetti M, Aleksova A, Zecchin M, Sinagra G, Biolo G, Guarnieri G. Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66 (ShcA) in pacemaker-implanted patients. Clin Exp Med 2007;7:16-23. (Pubitemid 46475004)
18. Norata GD, Marchesi P, Pirillo A, Uboldi P, Chiesa G, Maina V, Garlanda C, Mantovani A, Catapano AL. Long pentraxin 3, a key component of innate immunity, is modulated by highdensity lipoproteins in endothelial cells. Arterioscler Thromb Vasc Biol 2008;28:925-931. (Pubitemid 351544109)
19. Inoue K, Sugiyama A, Reid PC, Ito Y, Miyauchi K, Mukai S, Sagara M, Miyamoto K, Satoh H, Kohno I, Kurata T, Ota H, Mantovani A, Hamakubo T, Daida H, Kodama T. Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol 2007;27:161-167. (Pubitemid 46360394)
20. Bussolati B, Peri G, Salvidio G, Verzola D, Mantovani A, Camussi G. The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. J Immunol 2003;170:1466-1472. (Pubitemid 36139516)
21. Inforzato A, Baldock C, Jowitt TA, Holmes DF, Lindstedt R, Marcellini M, Rivieccio V, Briggs DC, Kadler KE, Verdoliva A, Bottazzi B, Mantovani A, Salvatori G, Day AJ. The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2. J Biol Chem 2010;285:17681-17692.
22. Inforzato A, Peri G, Doni A, Garlanda C, Mantovani A, Bastone A, Carpentieri A, Amoresano A, Pucci P, Roos A, Daha MR, Vincenti S, Gallo G, Carminati P, De Santis R, Salvatori G. Structure and function of the long pentraxin PTX3 glycosidic moiety: Fine-tuning of the interaction with C1q and complement activation. Biochemistry 2006;45: 11540-11551. (Pubitemid 44454002)
23. Deban L, Jarva H, Lehtinen MJ, Bottazzi B, Bastone A, Doni A, Jokiranta TS, Mantovani A, Meri S. Binding of the long pentraxin PTX3 to factor H: Interacting domains and function in the regulation of complement activation. J Immunol 2008; 181:8433-8440.
24. Gout E, Moriscot C, Doni A, Dumestre-Pérard C, Lacroix M, Pérard J, Schoehn G, Mantovani A, Arlaud GJ, Thielens NM. Soluble pattern-recognition molecules PTX3: A novel case of cross-talk between M-Ficolin interacts with the long pentraxin. J Immunol 2011;186:5815-5822.
25. Ma YJ, Doni A, Skjoedt MO, Honoré C, Arendrup M, Mantovani A, Garred P. Heterocomplexes of mannosebinding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. J Biol Chem 2011;286:3405-3417.
26. Camozzi M, Zacchigna S, Rusnati M, Coltrini D, Ramirez- Correa G, Bottazzi B, Mantovani A, Giacca M, Presta M. Pentraxin 3 inhibits fibroblast growth factor 2 dependent activation of smooth muscle cells in vitro and neointima formation in vivo. Arterioscler Thromb Vasc Biol 2005;25: 1837-1842. (Pubitemid 41243451)
27. Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, Deban L, Bastone A, Salvatori G, Mantovani A, Siracusa G, Salustri A. PTX3 interacts with inter-alfa-trypsin inhibitor. Implications for hyaluronan organization and cumulus oophorus expansion. J Biol Chem 2007;282:30161-30170.
28. Ma YJ, Doni A, Hummelshøj T, Honoré C, Bastone A, Mantovani A, Thielens NM, Garred P. Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem 2009;284: 28263-28275.
29. Reading PC, Bozza S, Gilbertson B, Tate M, Moretti S, Job ER, Crouch EC, Brooks AG, Brown LE, Bottazzi B, Romani L, Mantovani A. Antiviral activity of the long chain Pentraxin PTX3 against influenza viruses. J Immunol 2008;180: 3391-3398.
30. Bijl M, Horst G, Bijzet J, Bootsma H, Limburg PC, Kallenberg CG. Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages. Arthritis Rheum 2003;48:248-254. (Pubitemid 36091670)
31. Deban L, Bottazzi B, Garlanda C, Martinez de la Torre Y, Mantovani A. Pentraxins: Multifunctional proteins at the interface of innate immunity and inflammation. Biofactors 2009;35:138-145.
32. Deban L, Jaillon S, Garlanda C, Bottazzi B, Mantovani A. Pentraxins in innate immunity: Lessons from PTX3. Cell Tissue Res 2011;343:237-249.
33. Baruah P, Propato A, Dumitriu IE, Rovere-Querini P, Russo V, Fontana R, Accapezzato D, Peri G, Mantovani A, Barnaba V, Manfredi AA. The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens. Blood 2006;107:151-158. (Pubitemid 43053537)
34. Hollan I, Bottazzi B, Cuccovillo I, Førre ØT, Mikkelsen K, Saatvedt K, Almdahl SM,Mantovani A, Meroni PL. Increased levels of serum Pentraxin 3, a novel cardiovascular biomarker, in patients with inflammatory rheumatic disease. Arthrit Care Res 2010;62:378-385.
35. Matsui S, Ishii J, Kitagawa F, Kuno A, Hattori K, Ishikawa M, Okumura M, Kan S, Nakano T, Naruse H, Tanaka I, Nomura M, Hishida H, Ozaki Y. Pentraxin 3 in unstable angina and non-ST-segment elevation myocardial infarction. Atherosclerosis 2010;210:220-225.
36. Latini R, Maggioni AP, Peri G, Gonzini L, Lucci D, Mocarelli P, Vago L, Pasqualini F, Signorini S, Soldateschi D, Tarli L, Schweiger C, Fresco C, Cecere R, Tognoni G, Mantovani A. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation 2004;110:2349-2354. (Pubitemid 39407338)
37. Brügger-Andersen T, Pö nitz V, Kontny F, Staines H, Grundt H, Sagara M, Nilsen DW. The long pentraxin 3 (PTX3): A novel prognostic inflammatory marker for mortality in acute chest pain. Thromb Haemost 2009;102:555-563.