Acute and subchronic toxicity assessment of the hydroalcoholic extract of Stachys lavandulifolia in mice

Acta Medica Iranica

Volumn 49, Issue 12, 2011, Pages 769-775

  Monji, Faezeh ^a   Tehrani, Hiva Hossein ^a   Halvaei, Zahra ^a   Bidgoli, Sepideh Arbabi ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Acute toxicity; NOAEL; Stachys lavandulifolia; Subacute toxicity; Subchronic toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CHOLESTEROL; CREATININE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; STACHYS LAVANDULIFOLIA EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ACUTE TOXICITY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CHRONIC TOXICITY; CLINICAL OBSERVATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HEMATOLOGY; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; ORGAN WEIGHT; PERCOLATION METHOD; PLANT LEAF; STACHYS; STACHYS LAVANDULIFOLIA; TOXICITY TESTING; WEIGHT CHANGE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; EATING; FEMALE; MAXIMUM TOLERATED DOSE; MICE; ORGAN SIZE; PLANT EXTRACTS; STACHYS; TOXICITY TESTS, ACUTE; TOXICITY TESTS, SUBCHRONIC;

EID: 84856460383     PISSN: 00446025     EISSN: 17359694     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Skaltsa HD, Mavrommati A, Constantinidis T. A chemotaxonomic investigation of volatile constituents in Stachys subsect. Swainsonianeae (Labiatae). Phytochemistry 2001;57(2):235-44.
2. Skaltsa HD, Lazari DM, Chinou IB, Loukis AE. Composition and antibacterial activity of the essential oils of Stachys candida and S. chrysantha from southern Greece. Planta Med 1999;65(3):255-6.
3. Mozaffarian V. A dictionary of Iranian plant names. Iran: Farhang Moaser Press; 1996.
4. Rechinger KH. Labiatae. In: Rechinger KH, editor. Flora Iranica, No. 150. Graz: Akademische, Druck- und Verlagsanstalt; 1982; p. 354-95.
5. Basaran AA, Calis I, Anklin C, Nishibe S, Sticher O. Lavandulifolioside: a new phenylpropanoid glycoside from Stachys lavandulifolia. Helvetica Chimica Acta 1988;71(6):1483-90
6. Amin GH. Popular Medicinal Plants of Iran. Tehran: Health Ministry Press; 1991.
7. Rabbani M, Sajjadi SE, Zarei HR. Anxiolytic effects of Stachys lavandulifolia Vahl on the elevated plus-maze model of anxiety in mice. J Ethnopharmacol 2003;89(2-3):271-6.
8. Rabbani M, Sajjadi SE, Jalali A. Hydroalcohol extract and fractions of Stachys lavandulifolia Vahl: effects on spontaneous motor activity and elevated plus-maze behaviour. Phytother Res 2005;19(10):854-8.
9. Saeedi M, Morteza-Semnani K, Mahdavi MR, Rahimi F. Antimicrobial studies on extracts of four species of stachys. Indian J Pharm Sci 2008;70(3):403-6.
10. Khanavi M, Sharifzadeh M, Hadjiakhoondi A, Shafiee A. Phytochemical investigation and anti-inflammatory activity of aerial parts of Stachys byzanthina C. Koch. J Ethnopharmacol 2005;97(3):463-8.
11. Ramezani M, Hassanzadeh MK and Safdarabadi DM. Volatile constituents of Stachys lavandulifolia Vahl growing in Iran. ACGC Chem Res Commun 2002;15:15:20-3.
12. Javidnia K, Mojab F, Mojahedi SA. Chemical constituents of the essential oil of Stachys lavandulifolia Vahl from Iran. Iran J Pharmaceutical Res 2004;3:61-3.
13. http://www.unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev00/English/GHS-PART-3e.pdf.
14. Delazar A, Delnavazi MR, Nahar L, Moghadam SB, Mojarab M, Gupta A, Williams AS, Mukhlesur Rahman M, Sarker SD. Lavandulifolioside B: a new phenylethanoid glycoside from the aerial parts of Stachys lavandulifolia Vahl. Nat Prod Res 2011;25(1):8-16.
15. McNaught AD, Wilkinson A. Compendium of Chemical Terminology: IUPAC. Recommendations. 2nd ed. Oxford: Blackwell Scientific Publications; 1997.