An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: Incidence, risk factors and its impact on outcome

European Journal of Internal Medicine

Volumn 23, Issue 2, 2012, Pages 192-195

  Nasa, Prashant ^a   Juneja, Deven ^a   Singh, Omender ^a   Dang, Rohit ^a   Singh, Akhilesh ^a  

^a MAX SUPER SPECIALITY HOSPITAL   (India)

Author keywords

Blood stream infections; ESBL; Mortality; NDM 1

Indexed keywords

AMIKACIN; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; AZTREONAM; CEFEPIME; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; OFLOXACIN; PIPERACILLIN PLUS TAZOBACTAM; POLYMYXIN B; SULPERAZON; TIGECYCLINE;

ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM ISOLATE; BLOOD CULTURE; BLOODSTREAM INFECTION; CRITICALLY ILL PATIENT; ENTEROBACTERIACEAE INFECTION; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; FEMALE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION RISK; INTENSIVE CARE; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RISK ASSESSMENT;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BETA-LACTAMASES; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; HUMANS; INCIDENCE; INDIA; INTENSIVE CARE UNITS; KLEBSIELLA; KLEBSIELLA INFECTIONS; MALE; MIDDLE AGED; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84856446853     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2011.06.016     Document Type: Article

References (27)

1. D.L. Paterson Resistance in gram-negative bacteria: Enterobacteriaceae Am J Med 119 2006 20 28
2. D.L. Paterson, W.C. Ko, A. Von Gottberg, S. Mohapatra, J.M. Casellas, and H. Goossens Antibiotic therapy for Klebsiella pneumonia bacteremia: implications of production of extended-spectrum betalactamases Clin Infect Dis 39 2004 31 37 (Pubitemid 38879546)
3. R. Ramphal, and P.G. Ambrose Extended-spectrum beta-lactamases and clinical outcomes: current data Clin Infect Dis 42 2006 S164 S172
4. S. Nathisuwan, D.S. Burgess, and J.S. Lewis II ESBLs: epidemiology, detection and treatment Pharmacotherapy 21 2001 920 928
5. S.P. Hawser, S.K. Bouchillon, D.J. Hoban, R.E. Badal, P.R. Hsueh, and D.L. Paterson Emergence of high levels of extended-spectrum-β-lactamase- producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007 Antimicrob Agents Chemother 53 2009 3280 3284
6. L.B. Rice Successful interventions for gram-negative resistance to extended-spectrum β-lactam antibiotics Pharmacotherapy 19 1999 S120 S128
7. Y. Hirakata, J. Matsuda, Y. Miyazaki, S. Kamihira, S. Kawakami, and Y. Miyazawa Regional variation in the prevalence of extended-spectrum beta-lactamase-producing clinical isolates in the Asia-Pacific region (SENTRY 1998-2002) Diagn Microbiol Infect Dis 52 2005 323 329 (Pubitemid 41297571)
8. H.S. Sader, A. Hsiung, T.R. Fritsche, and R.N. Jones Comparative activities of cefepime and piperacillin/tazobactam tested against a global collection of Escherichia coli and Klebsiella spp. with an ESBL phenotype Diagn Microbiol Infect Dis 57 2007 341 344 (Pubitemid 46330648)
9. M. Dwivedi, A. Mishra, A. Azim, R.K. Singh, A.K. Baronia, and K.N. Prasad Ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae carrying multiple metallo-beta-lactamase genes Indian J Pathol Microbiol 52 2009 339 342
10. K.K. Kumarasamy, M.A. Toleman, T.R. Walsh, J. Bagaria, F. Butt, and R. Balakrishnan Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study Lancet Infect Dis 10 2010 597 602
11. P. Deshpande, C. Rodrigues, A. Shetty, F. Kapadia, A. Hedge, and R. Soman New Delhi metallo-b lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised J Assoc Physicians India 58 2010 147 149
12. Clinical and Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing: eighteenth informational supplement 2008 M100-S18
13. V. Gupta An update on newer beta-lactamases Indian J Med Res 126 2007 417 427
14. A.D. Harris, J.C. McGregor, J.A. Johnson, S.M. Strauss, A.C. Moore, and H.C. Standiford Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission Emerg Infect Dis 13 2007 1144 1149 (Pubitemid 47359156)
15. M. Ofner-Agostini, A. Simor, M. Mulvey, A. McGeer, Z. Hirji, and M. McCracken Risk factors for and outcomes associated with clinical isolates of Escherichia coli and Klebsiella species resistant to extended-spectrum cephalosporins among patients admitted to Canadian hospitals Can J Infect Dis Med Microbiol 20 2009 e43 e48
16. M. Tumbarello, M. Sali, E.M. Trecarichi, F. Leone, M. Rossi, and B. Fiori Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy Antimicrob Agents Chemother 52 2008 3244 3252
17. M.J. Schwaber, and Y. Carmeli Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis J Antimicrob Chemother 60 2007 913 920 (Pubitemid 47617735)
18. M.E. Falagas, and D.E. Karageorgopoulos Extended-spectrum beta-lactamase-producing organisms J Hosp Infect 73 2009 345 354
19. J. Rodríguez-Baño, and A. Pascual Clinical significance of extended-spectrum beta-lactamases Expert Rev Anti Infect Ther 6 2008 671 683
20. D.A. Schiappa, M.K. Hayden, M.G. Matushek, F.N. Hashemi, J. Sullivan, and K.Y. Smith Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: a case-control and molecular epidemiologic investigation J Infect Dis 174 1996 529 536 (Pubitemid 26299686)
21. B.N. Kim, J.H. Woo, M.N. Kim, J. Ryu, and Y.S. Kim Clinical implications of extended-spectrum beta-lactamase-producing Klebsiella pneumonia bacteraemia J Hosp Infect 52 2002 99 106 (Pubitemid 38001939)
22. B. Du, Y. Long, H. Liu, D. Chen, D. Liu, and Y. Xu Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bloodstream infection: risk factors and clinical outcome Intensive Care Med 28 2002 1718 1723 (Pubitemid 35435472)
23. A. Wong-Beringer, J. Hindler, M. Loeloff, A.M. Queenan, N. Lee, and D.A. Pegues Molecular correlation for the treatment outcomes in bloodstream infections caused by Escherichia coli and Klebsiella pneumoniae with reduced susceptibility to ceftazidime Clin Infect Dis 34 2002 135 146 (Pubitemid 34028343)
24. D.L. Paterson, W.C. Ko, A. Von Gottberg, J.M. Casellas, L. Mulazimoglu, and K.P. Klugman Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum b-lactamases: implications for the clinical microbiology laboratory J Clin Microbiol 39 2001 2206 2212 (Pubitemid 32531482)
25. T.R. Walsh, M.A. Toleman, L. Poirel, and P. Nordmann Metallo- betalactamases: the quiet before the storm? Clin Microbiol Rev 18 2005 306 325
26. A.M. Queenan, and K. Bush Carbapenemases: the versatile betalactamases Clin Microbiol Rev 20 2007 440 458
27. J.J. Yan, W.C. Ko, S.H. Tsai, H.M. Wu, and J.J. Wu Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying bla(IMP-8) in a university medical center in Taiwan J Clin Microbiol 39 2001 4433 4439