Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C 4 synthase

Biochemistry

Volumn 51, Issue 4, 2012, Pages 848-856

  Rinaldo Matthis, Agnes ^a   Ahmad, Shabbir ^a   Wetterholm, Anders ^a   Lachmann, Peter ^b   Morgenstern, Ralf ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANION FORMATION; CATALYTIC CYCLES; CATALYTIC MECHANISMS; DISSOCIATION CONSTANT; DRUG TARGETS; GLUTATHIONE TRANSFERASE; GLUTATHIONES; HOMOTRIMERS; INFLAMMATORY RESPONSE; INTEGRAL MEMBRANE PROTEINS; KINETIC CHARACTERIZATION; OVERALL REACTIONS; RATE-LIMITING STEPS; RELEASE EXPERIMENTS; SYNTHASES; THIOLATES;

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CRYSTALLOGRAPHY; DISSOCIATION; ENZYMES; PEPTIDES;

IONS;

ANION; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GLUTATHIONESULFONIC ACID; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE D4; LEUKOTRIENE E4; MONOMER; PROTON; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; CHEMICAL REACTION; CRYSTALLOGRAPHY; DISSOCIATION CONSTANT; ENZYME BINDING; HUMAN; INFLAMMATION; KINETICS; MOLECULE; PRIORITY JOURNAL; STEADY STATE; STOICHIOMETRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARGININE; BINDING, COMPETITIVE; BIOCATALYSIS; CATALYTIC DOMAIN; CYSTEINE; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; KINETICS; LEUKOTRIENE A4; LEUKOTRIENE C4; MOLECULAR TARGETED THERAPY; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECOMBINANT PROTEINS;

KOBUS;

EID: 84856444639     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201402s     Document Type: Article

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