Extremely sensitive and selective antibodies against the explosive 2,4,6-trinitrotoluene by rational design of a structurally optimized hapten

Journal of Molecular Recognition

Volumn 25, Issue 2, 2012, Pages 89-97

  Ramin, Steffen ^a   Weller, Michael G ^a  

^a BAM FEDERAL INSTITUTE FOR MATERIALS RESEARCH AND TESTING   (Germany)

Author keywords

ELISA; immunoassay; security; terrorism

Indexed keywords

ANTIBODY; BOVINE SERUM ALBUMIN; EXPLOSIVE; HAPTEN; TRINITROTOLUENE;

ANIMAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CALIBRATION; CATTLE; CHEMISTRY; CROSS REACTION; DRUG DESIGN; IMMUNIZATION; IMMUNOLOGY; NITROSATION; RABBIT; REVIEW; SYNTHESIS; TITRIMETRY;

ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CALIBRATION; CATTLE; CROSS REACTIONS; DRUG DESIGN; EXPLOSIVE AGENTS; HAPTENS; IMMUNIZATION; NITROSATION; RABBITS; SERUM ALBUMIN, BOVINE; TITRIMETRY; TRINITROTOLUENE;

BOVINAE; ORYCTOLAGUS CUNICULUS;

EID: 84856433261     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.2162     Document Type: Review

References (21)

1. Bahlmann A, Weller MG, Panne U, Schneider RJ,. 2009. Monitoring carbamazepine in surface and wastewaters by an immunoassay based on a monoclonal antibody. Anal. Bioanal. Chem. 395: 1809-1820.
2. Bauminger S, Kohen F, Lindner HR,. 1974. Steroids as haptens-Optimal design of antigens for formation of antibodies to steroid-hormones. J. Steroid Biochem. Mol. Biol. 5: 739-747.
3. Bhattacharjee Y,. 2008. Combating terrorism-New efforts to detect explosives require advances on many fronts. Science 320: 1416-1417. (Pubitemid 351929408)
4. Chappey ON, Sandouk P, Scherrmann JMG,. 1992. Monoclonal antibodies in hapten immunoassays. Pharm. Res. 9: 1375-1379.
5. Crampton MR, Cropper EL, Gibbons LM, Millar RW,. 2002. The nitration of arenes in perfluorocarbon solvents. Green Chem. 4: 275-278.
6. Ekins R,. 1981. The "Precision Profile": Its use in RIA assessment and design. The Ligand Quarterly 4: 33-44.
7. Goldman ER, Cohill TJ, Patterson CH, Anderson GP, Kusterbeck AW, Mauro JM,. 2003. Detection of 2,4,6-trinitrotoluene in environmental samples using a homogeneous fluoroimmunoassay. Environ. Sci. Technol. 37: 4733-4736. (Pubitemid 37266393)
8. Krämer PM, Kremmer E, Weber CM, Ciumasu IM, Forster S, Kettrup AA,. 2005. Development of new rat monoclonal antibodies with different selectivities and sensitivities for 2,4,6-trinitrotoluene (TNT) and other nitroaromatic compounds. Anal. Bioanal. Chem. 382: 1919-1933. (Pubitemid 41204522)
9. Little JR, Eisen HN,. 1966. Preparation and characterization of antibodies specific for 2,4,6-trinitrophenyl group. Biochemistry 5: 3385-3395.
10. Marco MP, Gee S, Hammock BD,. 1995. Immunochemical techniques for environmental-analysis. 2. Antibody-production and immunoassay development. Trends Analyt. Chem. 14: 415-425.
11. Newsome WH, Yeung JM, Collins PG,. 1993. Development of enzyme-immunoassay for captan and its degradation product tetrahydrophthalimide in foods. J. AOAC Int. 76: 381-386.
12. Rodbard D,. 1978. Statistical estimation of minimal detectable concentration (sensitivity) for radioligand assays. Anal. Biochem. 90: 1-12. (Pubitemid 9062229)
13. Smith RG, D'Souza N, Nicklin S,. 2008. A review of biosensors and biologically-inspired systems for explosives detection. Analyst 133: 571-584. (Pubitemid 351572825)
14. Szurdoki F, Bekheit HKM, Marco MP, Goodrow MH, Hammock BD,. 1995. Important factors in hapten design and enzyme-linked immunosorbent assay development. In New frontiers in agrochemical immunoassay, Kurtz DA, Skerritt JA, Stanker L, (eds). AOAC International: Gaithersburg; 38-62.
15. Walter MA, Panne U, Weller MG,. 2011. A novel immunoreagent for the specific and sensitive detection of the explosive triacetone triperoxide (TATP). Biosensors 1: 93-106.
16. Weller MG,. 1992. Strukturelle und kinetische Untersuchungen zur Entwicklung und Optimierung von Hapten-Enzymimmunoassays (ELISAs) am Beispiel der Bestimmung von Triazinherbiziden. PhD Thesis. Technische Universität München (German).
17. Weller MG, Schuetz AJ, Winklmair M, Niessner R,. 1999. Highly parallel affinity sensor for the detection of environmental contaminants in water. Anal. Chim. Acta 393: 29-41. (Pubitemid 29335988)
18. Wilbrand J,. 1863. Notiz über Trinitrotoluol. Justus Liebigs Ann. Chem. 128: 178-179.
19. Zeck A, Weller MG, Niessner R,. 1999. Characterization of a monoclonal TNT-antibody by measurement of the cross-reactivities of nitroaromatic compounds. Fresenius J. Anal. Chem. 364: 113-120.
20. Zeck A, Eickenberg A, Weller MG, Niessner R,. 2001. Highly sensitive immunoassay based on a monoclonal antibody specific for [4-arginine] microcystins. Anal. Chim. Acta 441: 1-13. (Pubitemid 32710098)
21. Zettner A, Duly PE,. 1974. Principles of competitive binding assays (saturation analyses). 2. Sequential saturation. Clin. Chem. 20: 5-14.