Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 2, 2012, Pages 155-157

  Roman Campos, Danilo ^a   Carneiro Júnior, Miguel A ^b   Prímola Gomes, Thales N ^b   Silva, Karina A ^b   Quintão Júnior, Judson F ^b   Gondim, Antonio N S ^a,c   Duarte, Hugo L ^b   Cruz, Jader S ^a   Natali, Antonio J ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

^c University of Bahia State   (Brazil)

Author keywords

Action potential duration; Potassium current; Spontaneous hypertensive rat; Treadmill running

Indexed keywords

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE WALL; HEART MUSCLE CELL; MALE; NONHUMAN; POTASSIUM CURRENT; RAT; SITTING; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; HEART VENTRICLES; HYPERTENSION; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, WISTAR; VENTRICULAR FUNCTION, LEFT;

EID: 84856427816     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05669.x     Document Type: Article

References (17)

1. Hasenfuss G. Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc. Res. 1998; 39: 60-76.
2. Cerbai E, Barbieri M, Li Q, Mugelli A. Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovasc. Res. 1994; 28: 1180-7.
3. Benitah JP, Gomez AM, Bailly P et al. Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. J. Physiol. 1993; 469: 111-38.
4. Hart G. Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc. Res. 1994; 28: 933-46.
5. Evans SJ, Levi AJ, Jones JV. Wall stress induced arrhythmia is enhanced by low potassium and early left ventricular hypertrophy in the working rat heart. Cardiovasc. Res. 1995; 29: 555-62.
6. Shipsey SJ, Bryant SM, Hart G. Effects of hypertrophy on regional action potential characteristics in the rat left ventricle: A cellular basis for T-wave inversion? Circulation 1997; 96: 2061-8.
7. 2+ handing and vulnerability to ventricular fibrillation in spontaneously hypertensive rats. Hypertension 1997; 30: 461-7.
8. Nho H, Tanaka K, Kim HS, Watanabe Y, Hiyama T. Exercise training in female patients with a family history of hypertension. Eur. J. Appl. Physiol. Occup. Physiol. 1998; 78: 1-6.
9. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS Jr. Relative intensity of physical activity and risk of coronary heart disease. Circulation 2003; 107: 1110-6.
10. Collins HL, Loka AM, DiCarlo SE. Daily exercise-induced cardioprotection is associated with changes in calcium proteins in hypertensive rats. Am. J. Physiol. Heart Circ. Physiol. 2005; 288: H532-40.
11. Gava NS, Veras-Silva AS, Negrao CE, Krieger EM. Low-intensity exercise training attenuates cardiac beta-adrenergic tone during exercise in spontaneously hypertensive rats. Hypertension 1995; 26: 1129-33.
12. Hefti F, Fischli W, Gerold M. Cilazapril prevents hypertension in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 1986; 8: 641-8.
13. Roman-Campos D, Duarte HL, Gomes ER et al. Investigation of the cardiomyocyte dysfunction in bradykinin type 2 receptor knockout mice. Life Sci. 2010; 87: 715-23.
14. + current in spontaneously hypertensive rats. Cardiovasc. Res. 2007; 74: 85-95.
15. Wolkowicz PE, Huang J, Umeda PK et al. Pharmacological evidence for Orai channel activation as a source of cardiac abnormal automaticity. Eur. J. Pharmacol. 2011; 668: 208-16.
16. Gioda CR, Roman-Campos D, Carneiro-Junior MA et al. Impaired cellular contractile function in thiamine-deficient rat cardiomyocytes. Eur. J. Heart Fail. 2009; 11: 1126-8.
17. McCrossan ZA, Billeter R, White E. Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy. Cardiovasc. Res. 2004; 63: 283-92.