Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy

Epilepsy Research

Volumn 98, Issue 2-3, 2012, Pages 130-134

  Contin, M ^a   Mohamed, S ^a   Albani, F ^a   Riva, R ^a   Baruzzi, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Elderly and very elderly patients; Levetiracetam; Oral clearance; Pharmacokinetics; Therapeutic drug monitoring

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CARBAMAZEPINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PROTON PUMP INHIBITOR; RUFINAMIDE; SEROTONIN UPTAKE INHIBITOR; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

AGED; ARTICLE; CONFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG MONITORING; EPILEPSY; FATIGUE; FEMALE; GERIATRIC PATIENT; HUMAN; INCIDENCE; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PARESTHESIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIDE EFFECT; SOMNOLENCE; STEADY STATE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; EPILEPSY; FEMALE; GERIATRICS; HUMANS; MALE; MIDDLE AGED; PIRACETAM; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES;

EID: 84856427715     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.08.020     Document Type: Article

References (13)

1. Contin M., Albani F., Riva R., Baruzzi A. Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. Ther. Drug Monit. 2004, 26:375-379.
2. Contin M., Mohamed S., Albani F., Riva R., Baruzzi A. Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2008, 873:129-132.
3. Dahlin M.G., Wide K., Ohman I. Age and comedication influence levetiracetam pharmacokinetics in children. Pediatr. Neurol. 2010, 43:231-235.
4. Ferrendelli J.A., French J., Leppik I., Morrell M.J., Herbeuval A., Han J., Magnus L. Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial. Epilepsy Behav. 2003, 4:702-709.
5. Forsgren L., Bucht G., Eriksson S., Bergmark L. Incidence and clinical characterization of unproved seizures in adults. A prospective population-based study. Epilepsia 1996, 37:224-229.
6. Freitas-Lima P., Alexandre V., Pereira L.R., Feletti F., Perucca E., Sakamoto A.C. Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. Epilepsy Res. 2011, 94:117-120.
7. French J. Use of levetiracetam in special populations. Epilepsia 2001, 42(Suppl. 4):40-43.
8. Hirsch L.J., Arif H., Buchsbaum R., Weitraub D., Lee J., Chag J.T., Resor S.R., Bazil C.W. Effect of age and comedication on levetiracetam pharmacokinetics and tolerability. Epilepsia 2007, 48:1351-1359.
9. Kutlu G., Gomceli Y.B., Unal Y., Inan L.E. Levetiracetam monotherapy for late poststroke seizures in the elderly. Epilepsy Behav. 2008, 13:542-544.
10. May T.W., Rambeck B., Jurgens U. Serum concentration of levetiracetam in epileptic patients: the influence of dose and comedication. Ther. Drug Monit. 2003, 25:690-699.
11. Patsalos P.N. The pharmacokinetic characteristics of levetiracetam. Methods Find. Exp. Clin. Pharmacol. 2003, 25:123-129.
12. Perucca E., Gidal B.E., Baltes E. Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials. Epilepsy Res. 2003, 53:47-56.
13. Poza J.J. Management of epilepsy in the elderly. Neuropsychiatr. Dis. Treat. 2007, 3:723-728.