Anxiolytic activity of methanol leaf extract of Achyranthes aspera Linn in mice using experimental models of anxiety

Indian Journal of Pharmacology

Volumn 44, Issue 1, 2012, Pages 63-67

  Barua, Chandana C ^a   Talukdar, Archana ^a   Begum, Shameem Ara ^a   Borah, Prabodh ^a   Lahkar, Mangala ^b  

^a ASSAM AGRICULTURAL UNIVERSITY   (India)

^b GAUHATI MEDICAL COLLEGE   (India)

Author keywords

Achyranthesaspera; anxiolytic activity; elevated plus maze; hole board; light dark exploration; MEAA; open field

Indexed keywords

ACHYRANTHES ASPERA EXTRACT; DIAZEPAM; METHANOL;

ACHYRANTHES ASPERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; IMMOBILIZATION; LIGHT EXPOSURE; MALE; MAZE TEST; MEDICINAL PLANT; MOUSE; NONHUMAN; PLANT LEAF; TRANQUILIZING ACTIVITY;

EID: 84856389116     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.91869     Document Type: Article

References (22)

1. Cross-national comparisons of the prevalences and correlates of mental disorders. WHO International Consortium in Psychiatric Epidemiology. Bull World Health Organ2000;78:413-26.
2. Kaplan HI, Sadock BJ. Comprehensive Textbook of Psychiatry. New York: Lippincott Williams and Wilkins; 2005.
3. Aziz A, Rahman M, Mondal AK, Muslim T, Rahman A, Quader A. 3-Acetoxy-6-benzoyloxyapagamide from Achyranthes aspera. Pharm J 2005;4:1816-20.
4. Vetrichelvan T, Jegadeesan M. Effect of alcohol extract of Achyranthes aspera Linn. on acute and sub-acute inflammation. Phytother Res 2003;17:77-9. (Pubitemid 36205464)
5. Workineh S, Eyasu M, Legesse Z, Asfaw D. Effect of Achyranthes aspera 0L. on fetal abortion, uterine and pituitary weights, serum lipids and hormones. Afr Health Sci 2006;6:108-12.
6. Kartik R, Rao CV, Trivedi SP, Pushpangadan P, Reddy GD. Amelioration effects against N-nitrosodiethylamine and CCl 4-induced hepatocarcinogenesis in Swiss albino rats by whole plant extract of Achyranthes aspera. Indian J Pharmacol 2010;42:370-5.
7. Barua CC, Talukdar A, Begum SA, Buragohain B, Roy JD, Borah RS, et al. Antidepressant-like effects of the methanol extract of Achyranthes aspera Linn. in animal models of depression. Pharmacologyonline 2009;2:587-94.
8. Barua CC, Begum SA, Talukdar A, Pathak DC, Barua AG, Borah P, et al. Effect of Achyranthes aspera Linn on modified forced swimming in rats. Pharmacologyonline 2010;1:183-91.
9. Barua CC, Begum SA, Talukdar A, Pathak DC, S0 arma DK, Bora RS. Wound healing activity of methanolic extract of leaves of Achyranthes aspera 0Linn using in vivo and in vitro model-A preliminary study. Indian J Anim Sci 2010;80:969-72.
10. Barua CC, Talukdar A, Begum SA, Lahon LC, Sarma DK, Pathak DC, et al. Antinociceptive activity of methanolic extract of leaves of Achyranthes aspera Linn. (Amaranthaceae) in animal models of nociception. Indian J Exp Biol 2010;48:817-21.
11. Harborne JB. Phytochemical Screening-Guide to modern techniques of plant analysis.2 nd ed. NewYork: Chapman and Hall; 1991. p.653.
12. Thippeswamy BS, Mishra B, Veerapur VP, Gupta G. Anxiolytic activity of Nymphaea alba Linn. in mice as experimental models of anxiety. Indian J Pharmacol 2011;43:50-5.
13. Vogel HG. Drug discovery and evaluation: Pharmacological Assay. Berlin Heidelberg New York:2002. p. 385.
14. Sonovane GS, Sarveiya VP, Kasture VS, Kasture SB. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav 2002;71:239-44.
15. Bhattacharyya SK, Satyan KS. Experimental methods for evaluation of psychotropic agents in rodents: Anti-anxiety agents. Indian J Exp Biol 1997;35:565-75. (Pubitemid 27511787)
16. Adeyemi OO, Yetmitan OK, Taiwo AE. Neurosedative and muscle relaxant activities of ethyl acetate extract of Baphia nitida AFZEL. J Ethnopharmacol 2006;106:312-6.
17. Jain NN, Ohal CC, Shroff RH, Somani RS, Kasture VS, Kasture SB. Clitoria ternatea and the CNS. Pharmacol Biochem Behav 2003;75:529-36. (Pubitemid 36936887)
18. Takeda H, Tsuji M, Matsumiya T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 1998;350:21-9. (Pubitemid 28288304)
19. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. London: Churchill Livingstone; 2003.
20. Gupta M, Mazumder UK, Kumar RS, Siva Kumar T, Vamsi ML. Antitumour activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci 2004;94:177-84. (Pubitemid 38405132)
21. Belzung C, Misslin R, Vogel E, Dodd RH, Chapounthier G. Anxiogenic effects of methyl-carboline-carboxylate in a light-dark choice situation. Pharmacol Biochem Behav 1987;28:29-33. (Pubitemid 17142735)
22. Chiej R. The McDonald Encyclopedia of Medicinal Plants. London: McDonald and Co. Ltd.; 1998.