Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats

Journal of Psychopharmacology

Volumn 25, Issue 12, 2011, Pages 1712-1719

  De Haas, Ria ^a   Nijdam, Annelies ^b   Westra, Tjalke A ^a   Kas, Martien J H ^a   Westenberg, Herman G M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Microdialysis; nucleus accumbens; obsessive compulsive disorder; rituals; theme

Indexed keywords

DOPAMINE; QUINPIROLE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; MALE; NEUROBIOLOGY; NONHUMAN; NUCLEUS ACCUMBENS; OBSESSIVE COMPULSIVE DISORDER; OPEN FIELD TEST; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TREATMENT DURATION;

ANIMALS; DOPAMINE; DOPAMINE AGONISTS; MALE; MICRODIALYSIS; MOTOR ACTIVITY; OBSESSIVE-COMPULSIVE DISORDER; QUINPIROLE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84856386664     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881110389093     Document Type: Article

References (34)

1. Aouizerate B, Cuny E, Bardinet E, Yelnik J, Martin-Guehl C, Rotge JY, et al. Distinct striatal targets in treating obsessive-compulsive disorder and major depression. J Neurosurg. 2009 ; 111: 775-779
2. de Oliveira AR, Reimer AE, Brandão ML. Dopamine D2 receptor mechanisms in the expression of conditioned fear. Pharmacol Biochem Behav. 2006 ; 84: 102-111 (Pubitemid 43975554)
3. Denys D, van Megen H, Westenberg H. Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: An open label study. J Clin Psychiatry. 2002 ; 63: 8
4. Denys D, Klompmakers AA, Westenberg HGM. Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine. Psychopharmacology. 2004a ; 176: 195-203 (Pubitemid 39517949)
5. Denys D, van der Wee N, Janssen J, de Geus F, Westenberg HGM. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol Psychiatry. 2004b ; 55: 1041-1045 (Pubitemid 38581920)
6. Denys D. Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders. Psychiatr Clin N Am. 2006 ; 29: 553-584
7. Denys D, Mantione M. Deep brain stimulation in obsessive-compulsive disorder. Prog Brain Res. 2009 ; 175: 419-427
8. Dvorkin A, Perreault ML, Szechtman H. Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder. Behav Brain Research. 2006 ; 169: 303-311
9. Einat H, Szechtman H. Longlasting consequences of chronic treatment with the dopamine agonist quinpirole for the undrugged behavior of rats. Behav Brain Res. 1993 ; 54: 35-41 (Pubitemid 23134664)
10. Joel D, Avisar A. Excessive lever pressing following post-training signal attenuation in rats: A possible animal model of obsessive-compulsive disorder?. Behav Brain Res. 2001 ; 123: 77-87 (Pubitemid 32506825)
11. Joel D. Current animal models of obsessive compulsive disorder: A critical review. Prog Neuropsychopharmacol Biol Psychiatry. 2006 ; 30: 374-388
12. Koeltzow TE, Austin JD, Vezina P. Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow. Neuropharmacology. 2003 ; 44: 102-110 (Pubitemid 36135847)
13. Korff S, Harvey BH. Animal models of obsessive-compulsive disorder: Rationale to understanding psychobiology and pharmacology. Psychiatr Clin N Am. 2006 ; 29: 371-390 (Pubitemid 44294451)
14. Magnusson MS. Discovering hidden time patterns in behavior: T-patterns and their detection. Behav Res Methods Instrum Comput. 2000 ; 32: 93-110
15. Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008 ; 13: 2121-2134
16. Mundt A, Klein J, Joel D, Heinz A, Djodari-Irani A, Harnack D, et al. High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur J Neurosci. 2009 ; 29: 2401-2412
17. Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, et al. Treatment non-response in OCD: Methodological issues and operational definitions. Int J Neuropsychopharmacol. 2002 ; 5: 181-191 (Pubitemid 34669829)
18. Paxinos G, Watson C The Rat Brain in Stereotaxic Coordinates. San Diego: Academic Press ; 2005 :
19. Perreault ML, Seeman P, Szechtman H. Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive compulsive disorder (OCD). Behav Neurosci. 2007 ; 121: 976-991 (Pubitemid 350051300)
20. Santiago M, Westerink BH. Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes. Naunyn Schiedebergs Arch Pharmacol. 1990 ; 342: 407-414 (Pubitemid 20284123)
21. Sasson Y, Zohar J, Chopra M, Lustig M, Iancu I, Hendler T. Epidemiology of obsessive-compulsive disorder: A world view. J Clin Psychiatry. 1997 ; 12: 7-10 (Pubitemid 27516504)
22. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998 ; 20: 22-23
23. Sturm V, Lenartz D, Koulousaki A, Treuer H, Herholz K, Klein JC, et al. The nucleus accumbens: A target for deep brain stimulation in obsessive-compulsive and anxiety disorders. J Chem Neuroanat. 2003 ; 26: 293-299 (Pubitemid 38077152)
24. Sullivan RM, Talangbayan H, Einat H, Szechtman H. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience. 1998 ; 83: 781-789 (Pubitemid 28068898)
25. Szechtman H, Eckert MJ, Tse WS, Boersma JT, Bonura CA, McClelland JZ, et al. Compulsive checking behavior of quinpirole-sensitized rats as an animal model of obsessive-compulsive disorder (OCD): Form and control. BMC Neurosci. 2001 ; 2: 4
26. Szechtman H, Sulis W, Eilam D. Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci. 1998 ; 112: 1475-1485 (Pubitemid 29052635)
27. van der Wee NJ, Stevens H, Hardeman JA, Mandl RC, Denys DA, van Megen HJ, et al. Enhanced dopamine transporter density in psychotropic-naive patients with obsessive-compulsive disorder shown by [123I]ß-CIT SPECT. Am J Psychiatry. 2004 ; 161: 2201-2206 (Pubitemid 39587284)
28. Vulink NCC, Denys D, Fluitman SBAHA, Meinardi JCM, Westenberg HGM. Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: A randomized, double-blind, placebo-controlled study of 76 patients. J Clin Psychiatry. 2009 ; 70: 1001-1008
29. Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature. 2007 ; 448: 894-900 (Pubitemid 47312780)
30. Westenberg HGM, Fineberg NA, Denys D. Neurobiology of obsessive-compulsive disorder: Serotonin and beyond. CNS Spectr. 2007 ; 12: 14-27
31. Winter C, Mundt A, Jalali R, Joel D, Harnack D, Morgenstern R, et al. High-frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats. Exp Neurol. 2008 ; 210: 217-228
32. Zadicario P, Ronen S, Eilam D. Modulation of quinpirole-induced compulsive-like behavior in rats by environmental changes: Implications for OCD rituals and for exploration and navigation. BMC Neurosci. 2007 ; 8: 23
33. Zor R, Hermesh H, Szechtman H, Eilam D. Turning order into chaos through repetition and addition of elementary acts in obsessive-compulsive disorder (OCD). World J Biol Psychiatry. 2009a ; 10: 480-487
34. Zor R, Keren H, Hermesh H, Szechtman H, Mort J, Eilam D. Obsessive-compulsive disorder: A disorder of pessimal (non-functional) motor behaviour. Acta Psychiatr Scand. 2009b ; 120: 288-298