The Impact of Alcohol on BCG-Induced Immunity Against Mycobacterium tuberculosis

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 2, 2012, Pages 310-317

  Porretta, Elizabeth ^a   Happel, Kyle I ^a   Teng, Xu S ^a   Ramsay, Alistair ^b   Mason, Carol M ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; BCG Vaccination; CD4 + Lymphocytes; IFN ; Mycobacterium tuberculosis

Indexed keywords

ALCOHOL; BCG VACCINE; GAMMA INTERFERON;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; IMMUNE RESPONSE; IMMUNITY; LYMPH NODE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS; VACCINATION;

ALCOHOLISM; ANIMALS; BCG VACCINE; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DIET; INTERFERON-GAMMA; INTERLEUKIN-10; LUNG; LYMPH NODES; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

MURINAE; MUS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 84856365979     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01624.x     Document Type: Article

References (60)

1. Anderson G, Jenkinson E, Moore N, Owen J (1993) MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature362:70-73.
2. Antas PRZ, Castello-Branco LRR (2008) New vaccines against tuberculosis: lessons learned from BCG immunization in Brazil. Trans R Soc Trop Med Hyg102:628-630.
3. ATS/CDC (2000) Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med161:S221-S247.
4. Baldwin S, D'Souza C, Roberts A, Kelly B, Frank A, Lui M, Ulmer J, Huygen K, McMurray D, Orme I (1998) Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect Immun66:2951-2959.
5. Barber A, Coyle S, Marano M, Fischer E, Calvano S, Fong Y, Moldawer L, Lowry S (1993) Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol150:1999-2006.
6. Borgdorff M, Veen J, Kalisvaart N, Nagelkerke N (1998) Mortality among tuberculosis patients in the Netherlands in the period 1993-1995. Eur Respir J11:816-820.
7. Bourke G, Daly L, McGilvray J (1985) Interpretation and Uses of Medical Statistics. 3rd ed. Blackwell Scientific Publications, Oxford.
8. Brooks J, Frank A, Keen M, Belisle J, Orme I (2001) Boosting vaccine for tuberculosis. Infect Immun69:2714-2717.
9. Buskin S, Gale J, Weiss N, Nolan C (1994) Tuberculosis risk factors in adults in King County, Washington, 1988 through 1990. Am J Public Health84:1750-1756.
10. Collins C, Norris S, McEntee G, Traynor O, Bruno L, Boehmer HV, Hegarty J, O'Farrelly C (1996) RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation. Eur J Immunol26:3114-3118.
11. Cooper A, Dalton D, Stewart T, Griffin J, Russell D, Orme I (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med178:2243-2247.
12. Deaciuc I, Alappat J, McDonough K, D'Souza N (1996) Interleukin-6 and tumor necrosis factor-α clearance and metabolism in vivo and by the isolated, perfused liver in the rat: effect of acute alcohol administration. Alcohol Clin Exp Res20:293-301.
13. Department of Health and Human Services (2009) Biosafety level 3, in Biosafety in Microbiological and Biomedical Laboratories [Centers for Disease Control website]. 5th ed. (Wilson D, Chosewood L eds), pp 38-45. US Government Printing Office, Washington. Available at: Accessed December 28, 2010.
14. D'Souza N, Bagby G, Nelson S, Lang C, Spitzer J (1989) Acute alcohol infusion suppresses endotoxin-induced serum tumor necrosis factor. Alcohol Clin Exp Res13:295-298.
15. Edsen-Moore M, Fan J, Ness K, Marietta J, Cook R, Schleuter A (2008) Effects of chronic ethanol feeding on murine dendritic cell numbers, turnover rate, and dendropoiesis. Alcohol Clin Exp Res32:1309-1320.
16. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N, Brenner D, Thurman R (2001) Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Alcohol Clin Exp Res25:1360-1367.
17. Fan J, Edsen-Moore MR, Turner LE, Cook RT, Legge KL, Waldschmidt TJ, Schlueter AJ (2011) Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res35:47-59.
18. Flynn J (2004) Immunology of tuberculosis and implications in vaccine development. Tuberculosis84:93-101.
19. Flynn J, Chan J, Triebold K, Dalton D, Stewart T, Bloom B (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med178:2249-2254.
20. Friedman L, Sullivan G, Bevilaqua R, Loscos R (1987) Tuberculosis screening in alcohol and drug addicts. Am Rev Respir Dis136:1188-1192.
21. Goonetilleke N, McShane H, Hannan C, Anderson R, Brookes R, Hill A (2003) Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of Bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus ankara. J Immunol171:1602-1609.
22. Grode L, Seiler P, Baumann S, Hess J, Brinkmann V, Eddine A, Mann P, Goosmann C, Bandermann S, Smith D, Bancroft G, Reyrat J, vanSoolingen D, Raupach B, Kaufmann S (2005) Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis Bacille Calmette-Guérin mutant that secrete listeriolysin. J Clin Invest115:2472-2479.
23. Grossman A, Astley S, Liggitt H, Clarren S, Shiota F, Kennedy B, Thouless M, Maggio-Price L (1993) Immune function in offspring of nonhuman primates (Macaca nemestrina) exposed to 1.8g/kg ethanol during pregnancy: preliminary observations. Alcohol Clin Exp Res17:822-827.
24. Gurung P, Young BM, Coleman RA, Wiechert S, Turner LE, Ray NB, Waldschmidt TJ, Legge KL, Cook RT (2009) Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation. J Leuko Biol85:34-43.
25. Hagedorn H, Rettmann N, Dieperink E, Durfee J, Aqel B (2010) Antibody response to hepatitis B vaccine in substance abuse disorder patients. Drug Alcohol Depend107:39-43.
26. Heinz R, Waltenbaugh C (2007) Ethanol consumption modifies dendritic cell antigen presentation in mice. Alcohol Clin Exp Res31:1759-1771.
27. Hinchey J, Lee S, Jeon B, Basaraba R, Venkataswamy M, Chen B, Chan J, Braunstein M, Orme I, Derrick S, Morris S, Jacobs WJr, Porcelli S (2007) Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. J Clin Invest117:2279-2288.
28. Hong F, Kim W, Tian Z, Jaruga B, Ishac E, Shen X, Gao B (2002) Elevated IL-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins. Oncogene21:32-43.
29. Hudolin V (1975) Tuberculosis and alcoholism. Ann NY Acad Sci252:353-364.
30. Kamimura S, Tsukamoto H (1995) Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatol21:1304-1309.
31. Kaufmann SHE, Hussey G, Lambert PH (2010) New vaccines for tuberculosis. Lancet375:2110-2119.
32. Kim H, Harrington R, VanRompaey S, Kitahata M (2008) Independent clinical predictors of impaired response to hepatitis B vaccination in HIV-infected persons. Int J STD AIDS19:600-604.
33. Kline S, Hedemark L, Davies S (1995) Outbreak of tuberculosis among regular patrons of a neighborhood bar. N Engl J Med333:222-227.
34. Kulkarni P, Raut S, Patki P, Phadke M, Jadhav S, Kapre S, Dhorje S, Godse S (2006) Immunogenicity of a new, low-cost recombinant hepatitis B vaccine derived from Hansenula polymorpha in adults. Vaccine24:3457-3460.
35. Lau A, Abe M, Thomson A (2006) Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J Leukoc Biol79:941-953.
36. Lin H, Yang S, Zeldin G, Diehl A (1998) Chronic ethanol consumption induces the production of tumor necrosis factor-α and related cytokines in liver and adipose tissue. Alcohol Clin Exp Res22:231S-237S.
37. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G (2004) Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J Immunol173:3398-3407.
38. Martinez F, Abril E, Earnest D, Watson R (1992) Ethanol and cytokine secretion. Alcohol9:455-458.
39. Mason C, Dobard E, Kolls J, Nelson S (1998) Effect of alcohol on bacterial translocation in rats. Alcohol Clin Exp Res22:1640-1645.
40. Mason C, Dobard E, Shellito J, Nelson S (2001) CD4+ lymphocyte responses to pulmonary infection with Mycobacterium tuberculosis in naive and vaccinated BALB/c mice. Tuberculosis81:327-334.
41. Mason C, Dobard E, Zhang P, Nelson S (2004) Alcohol exacerbates murine pulmonary tuberculosis. Infect Immun72:2556-2563.
42. Mikszta J, Waltenbaugh C, Kim B (1995) Impaired antigen presentation by splenocytes of ethanol-consuming C57BL/6 mice. Alcohol12:265-271.
43. Nalpas B, Thepot V, Driss F, Pol S, Courouce A, Saliou P, Berthelot P (1993) Secondary immune response to hepatitis B virus vaccine in alcoholics. Alcohol Clin Exp Res17:295-298.
44. Nelson S, Bagby G, Bainton B, Summer W (1989a) The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J Infect Dis160:422-429.
45. Nelson S, Bagby G, Summer W (1989b) Alcohol suppresses lipopolysaccharide-induced tumor necrosis factor activity in serum and lung. Life Sci44:673-676.
46. Plackett T, Jarrett J, Gamelli R, Kovacs E (2005) A low blood ethanol level is associated with improved cytokine production in aged mice after traumatic injury. J Trauma59:984-989.
47. Research Animal Resources (2004) Reference values for laboratory animals [University of Minnesota website]. Available at: Accessed December 28, 2010.
48. Siggins R, Bagby G, Molina P, Dufour J, Nelson S, Zhang P (2009) Alcohol exposure impairs myeloid dendritic cell function in rhesus macaques. Alcohol Clin Exp Res33:1524-1531.
49. Sipp T, Blank S, Lee E, Meadows G (1993) Plasma corticosterone response to chronic ethanol consumption and exercise stress. Proc Soc Exp Biol Med204:184-190.
50. Spies C, vonDossow V, Eggers V, Jetschmann G, El-Hilali R, Egert J, Fischer M, Schroder T, Hoflich C, Sinha P, Paschen C, Mirsalim P, Brunsch R, Hopf J, Marks C, Wernecke K, Pragst F, Ehrenreich H, Muller C, Tonnesen H, Oelkers W, Pohde W, Stein S, Kox W (2004) Altered cell-mediated immunity and increased post-operative infection rate in long-term alcoholic patients. Anesthesiology100:1088-1100.
51. Stoltz D, Nelson S, Kolls J, Zhang P, Bohm R, Murphy-Corb M, Bagby G (2000) In vitro ethanol suppresses alveolar macrophage TNF-alpha during simian immunodeficiency virus infection. Am J Respir Crit Care Med161:135-140.
52. Subcommittee on Laboratory Animal Nutrition, Committee on Animal Nutrition, Board on Agriculture, and National Research Council (1995) Nutrient requirements of the mouse, in Nutrient requirements of laboratory animals [National Academies Press website]. 1995 4th revised ed. Available at: Accessed December 28, 2010.
53. Szabo G (1998) Monocytes, alcohol and altered immunity. Alcohol Clin Exp Res22:216S-219S.
54. Szabo G, Catalano D, White B, Mandrekar P (2004) Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res28:824-828.
55. Szabo G, Mandrekar P, Catalano D (1995) Inhibition of superantigen-induced T cell proliferation and monocyte IL-1β, TNF-α, and IL-6 production by acute ethanol treatment. J Leukoc Biol58:342-350.
56. Waltman C, Blevins L, Boyd G, Wand G (1993) The effects of mild ethanol intoxication on the hypothalamic-pituitary-adrenal axis in nonalcoholic men. Clin Endocr Metab77:518-522.
57. Wang L, Lin H (2007) Ethnicity, substance abuse, and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination. J Hepatol46:1018-1025.
58. Wayne L, Sohaskey C (2001) Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol55:139-163.
59. World Health Organization (2010) Tuberculosis fact sheet, 2010. [World Health Organization website]. Available at: Accessed November 10, 2010.
60. Zisman D, Streiter R, Kinkel S, Tsai W, Wilkowski J, Bucknell K, Standiford T (1998) Ethanol feeding impairs innate immunity and alters the expression of Th1- and Th2-phenotype cytokines in murine Klebsiella pneumonia. Alcohol Clin Exp Res22:621-627.