QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone

Human Psychopharmacology

Volumn 27, Issue 1, 2012, Pages 39-42

  Suzuki, Yutaro ^a   Fukui, Naoki ^a   Watanabe, Junzo ^a   Ono, Shin ^a   Sugai, Takuro ^a   Tsuneyama, Nobuto ^a   Saito, Mami ^a   Inoue, Yoshimasa ^b   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b MP Technopharma Corporation Technology Department   (Japan)

Author keywords

paliperidone; pharmacodynamics; pharmacokinetics; QT interval; risperidone (RIS)

Indexed keywords

PALIPERIDONE; RISPERIDONE;

ADULT; ARTICLE; BEDTIME DOSAGE; DELUSIONAL DISORDER; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG METABOLISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; PRIORITY JOURNAL; PSYCHOSIS; QT INTERVAL; QT PROLONGATION; SCHIZOPHRENIA; SUDDEN DEATH;

ADULT; AGE FACTORS; ANTIPSYCHOTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; ISOXAZOLES; LONG QT SYNDROME; MALE; PYRIMIDINES; RISPERIDONE; YOUNG ADULT;

EID: 84856361240     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.1258     Document Type: Article

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