Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipients

Human Immunology

Volumn 73, Issue 2, 2012, Pages 186-192

  Sadeghi, Mahmoud ^a   Lahdou, Imad ^a   Daniel, Volker ^a   Schnitzler, Paul ^a   Fusch, Gerhard ^b   Schefold, Joerg C ^c   Zeier, Martin ^a   Iancu, Mircea ^a   Opelz, Gerhard ^a   Terness, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MCMASTER UNIVERSITY   (Canada)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Inflammatory mediators; Kidney allograft; Metabolism; Viral infection

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; KYNURENINE; PHENYLALANINE; QUINOLINIC ACID; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; DISEASE SEVERITY; FEMALE; GRAFT RECIPIENT; HUMAN; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TH1 CELL; TH2 CELL;

CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PHENYLALANINE; TRYPTOPHAN; UP-REGULATION;

EID: 84856335453     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.11.002     Document Type: Article

References (34)

1. Ricart M.J., Malaise J., Moreno A., Crespo M., Fernández-Cruz L. Cytomegalovirus: occurrence, severity, and effect on graft survival in simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 2005, 20(suppl 2):25-32. Euro-SPK Study Group.
2. Randhawa P., Uhrmacher J., Pasculle W., Vats A., Shapiro R., Eghtsead B., et al. A comparative study of BK and JC virus infections in organ transplant recipients. J Med Virol 2005, 77:238-243.
3. Eid A.J., Razonable R.R. New developments in the management of cytomegalovirus infection after solid organ transplantation. Drugs 2010, 70:965-981.
4. Kotton C.N., Kumar D., Caliendo A.M., Asberg A., Chou S., Snydman D.R., et al. International consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation 2010, 89:779-795.
5. Beisel W.R. Herman Award Lecture, 1995: infection-induced malnutrition-from cholera to cytokines. Am J Clin Nutr 1995, 62:813-819.
6. Matthews D.E. An overview of phenylalanine and tyrosine kinetics in humans. J Nutr 2007, 137(suppl 1):1549S-1555S.
7. Klassen P., Fürst P., Schulz C., Mazariegos M., Solomons N.W. Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue. Am J Clin Nutr 2001, 73:647-652.
8. Zangerle R., Kurz K., Neurauter G., Kitchen M., Sarcletti M., Fuchs D. Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy. Brain Behav Immun 2010, 24:403-408.
9. Hehir D.J., Jenkins R.L., Bistrian B.R., Wagner D., Moldawer L.L., Young V.R., et al. Abnormal phenylalanine hydroxylation and tyrosine oxidation in a patient with acute fulminant liver disease with correction by liver transplantation. Gastroenterology 1985, 89:659-663.
10. Moffett J.R., Namboodiri M.A. Tryptophan and the immune response. Immunol Cell Biol 2003, 81:247-265.
11. Curti A., Trabanelli S., Salvestrini V., Baccarani M., Lemoli R.M. The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology. Blood 2009, 113:2394-2401.
12. Vincendeau P., Lesthelle S., Bertazzo A., Okomo-Assoumou M.C., Allegri G., Costa C.V. Importance of l-tryptophan metabolism in trypanosomiasis. Adv Exp Med Biol 1999, 467:525-531.
13. Zelante T., Fallarino F., Bistoni F., Puccetti P., Romani L. Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host. Microbes Infect 2009, 11:133-141.
14. Terness P., Chuang J.J., Opelz G. The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends Immunol 2006, 27:68-73.
15. Zeden J.P., Fusch G., Holtfreter B., Schefold J.C., Reinke P., Domanska G., et al. Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. Anaesthesiol Intensive Care 2010, 38:307-316.
16. Bechert C.J., Schnadig V.J., Payne D.A., Dong J. Monitoring of BK viral load in renal allograft recipients by real-time PCR assays. Am J Clin Pathol 2010, 133:242-250.
17. Asadullah K., Prösch S., Audring H., Büttnerova I., Volk H.D., Sterry W., et al. A high prevalence of cytomegalovirus antigenaemia in patients with moderate to severe chronic plaque psoriasis: an association with systemic tumour necrosis factor alpha overexpression. Br J Dermatol 1999, 141:94-102.
18. Sadeghi M., Daniel V., Schnitzler P., Lahdou I., Naujokat C., Zeier M., et al. Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation 2009, 88:1109-1116.
19. Landry M.L., Ferguson D. Comparison of quantitative cytomegalovirus antigenemia assay with culture methods and correlation with clinical disease. J Clin Microbiol 1993, 31:2851-2856.
20. Schefold J.C., Zeden J.P., Fotopoulou C., von Haehling S., Pschowski R., Hasper D., et al. Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. Nephrol Dial Transplant 2009, 24:1901-1908.
21. Widner B., Sepp N., Kowald E., Ortner U., Wirleitner B., Fritsch P., et al. Enhanced tryptophan degradation in systemic lupus erythematosus. Immunobiology 2000, 201:621-630.
22. Chan D.L., Rozanski E.A., Freeman L.M. Relationship among plasma amino acids, C-reactive protein, illness severity, and outcome in critically ill dogs. J Vet Intern Med 2009, 23:559-563.
23. Costalonga E.C., Melo N.C., Rodrigues C.E., Sette L.H., Ianhez L.E. The potential role of C-reactive protein in distinguishing cytomegalovirus from tuberculosis and bacterial infections in renal transplant recipients. Clin Transpl 2009, 23:710-715.
24. Rowshani A.T., Bemelman F.J., van Leeuwen E.M., van Lier R.A., ten Berge I.J. Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation 2005, 79:381-386.
25. Marcén R. Immunosuppressive drugs in kidney transplantation: impact on patient survival, and incidence of cardiovascular disease, malignancy and infection. Drugs 2009, 69:2227-2243.
26. Schroecksnadel K., Zangerle R., Bellmann-Weiler R., Garimorth K., Weiss G., Fuchs D. Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infection. Curr Drug Metab 2007, 8:225-236.
27. Eggers V., Schilling A., Kox W.J., Spies C. [Septic encephalopathy. Diagnosis und therapy]. Anaesthesist 2003, 52:294-303.
28. van de Poll M.C., Soeters P.B., Deutz N.E., Fearon K.C., Dejong C.H. Renal metabolism of amino acids: its role in interorgan amino acid exchange. Am J Clin Nutr 2004, 79:185-197.
29. Li J., Dangott L.J., Fitzpatrick P.F. Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry. Biochemistry 2010, 49:3227-3235.
30. Neurauter G., Schröcksnadel K., Scholl-Bürgi S., Sperner-Unterweger B., Schubert C., Ledochowski M., et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr Drug Metab 2008, 9:622-627.
31. Bodaghi B., Goureau O., Zipeto D., Laurent L., Virelizier J.L., Michelson S. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells. J Immunol 1999, 162:957-964.
32. Zhang Y., Gu X., Yuan X. Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons. Eur J Neurosci 2007, 25:1341-1348.
33. Jitkaew S., Trebinska A., Grzybowska E., Carlsson G., Nordström A.Lehtiö J., et al. N(alpha)-tosyl-l-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1. J Biol Chem 2009, 284:27827-27837.
34. Schumacher U., Lukacs Z., Kaltschmidt C., Freudlsperger C., Schulz D., Kompisch K., et al. High concentrations of phenylalanine stimulate peroxisome proliferator-activated receptor gamma: implications for the pathophysiology of phenylketonuria. Neurobiol Dis 2008, 32:385-390.