Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas

Histopathology

Volumn 60, Issue 3, 2012, Pages 516-519

  Halle, Mari Kyllesø ^a,b   Werner, Henrica Maria Johanna ^a,b   Krakstad, Camilla ^a,b   Birkeland, Even ^a,b   Wik, Elisabeth ^a,b   Trovik, Jone ^a,b   Salvesen, Helga B ^a,b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FORMALDEHYDE; HEMATOXYLIN; PHOSPHATIDYLINOSITOL 3 KINASE;

AGE DISTRIBUTION; AGED; CANCER PATIENT; CANCER SURVIVAL; COPY NUMBER VARIATION; DISEASE SPECIFIC SURVIVAL; ENDOMETRIUM CARCINOMA; FEMALE; FROZEN SECTION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LETTER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METHYLATION; PATIENT SELECTION; PHENOTYPE; PREMENOPAUSE; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; TUMOR CELL;

ADENOCARCINOMA; CELL COUNT; CELL PROLIFERATION; CRYOPRESERVATION; ENDOMETRIAL NEOPLASMS; FEMALE; FROZEN SECTIONS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; TISSUE BANKS;

EID: 84856303989     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04057.x     Document Type: Letter

References (6)

1. Trovik J, Wik E, Stefansson IM et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin. Cancer Res. 2011; 17; 3368-3377.
2. Hudson TJ, Anderson W, Artez A et al. International network of cancer genome projects. Nature 2010; 464; 993-998.
3. Salvesen HB, Carter SL, Mannelqvist M et al. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc. Natl Acad. Sci. USA 2009; 106; 4834-4839.
4. Engelsen IB, Mannelqvist M, Stefansson IM et al. Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma. Br. J. Cancer 2008; 98; 1662-1669.
5. Salvesen HB, Das S, Akslen LA. Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis. Clin. Cancer Res. 2000; 6; 153-159.
6. Bast RC Jr, Hennessy B, Mills GB. The biology of ovarian cancer: new opportunities for translation. Nat. Rev. Cancer 2009; 9; 415-428.