The metabolically healthy but obese phenotype in African Americans

Journal of Clinical Hypertension

Volumn 14, Issue 2, 2012, Pages 92-96

  Cherqaoui, Rabia ^a   Kassim, Thaslim A ^a   Kwagyan, John ^b   Freeman, Clyde ^a   Nunlee Bland, Gail ^a   Ketete, Muluemebet ^a   Xu, Shichen ^a   Randall, Otelio S ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Delaware   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AFRICAN AMERICAN; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLICALLY HEALTHY BUT OBESE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PULSE PRESSURE; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADULT; AFRICAN AMERICANS; BODY MASS INDEX; CHOLESTEROL, HDL; FEMALE; HUMANS; MALE; OBESITY; OBESITY, ABDOMINAL; PHENOTYPE; WAIST-HIP RATIO; YOUNG ADULT;

EID: 84856298509     PISSN: 15246175     EISSN: 17517176     Source Type: Journal    
DOI: 10.1111/j.1751-7176.2011.00565.x     Document Type: Article

References (39)

1. Haslam DW, James WP. Obesity. Lancet. 2005;366:1197-1209.
2. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549-1555.
3. Brochu M, Tchernof A, Dionne IJ, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab. 2001;86:1020-1025.
4. Stefan N, Kantartzis K, Machann J, et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med. 2008;168:1609-1616.
5. Ferrannini E, Haffner SM, Mitchell BD, et al. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 1991;34:416-422.
6. Bonora E, Kiechl S, Willeit J, et al. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes. 1998;47:1643-1649.
7. Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008;168:1617-1624.
8. Karelis AD, St-Pierre DH, Conus F, et al. Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab. 2004;89:2569-2575.
9. Marin P, Andersson B, Ottosson M, et al. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism. 1992;41:1242-1248.
10. Albu JB, Curi M, Shur M, et al. Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity. Am J Physiol. 1999;277:E551-E560.
11. Carroll JF, Fulda KG, Chiapa AL, et al. Impact of race/ethnicity on the relationship between visceral fat and inflammatory biomarkers. Obesity. 2009;17:1420-1427.
12. Hill JO, Sidney S, Lewis CE, et al. Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) Study. Am J Clin Nutr. 1999;69:381-387.
13. Perry AC, Applegate EB, Jackson ML, et al. Racial differences in visceral adipose tissue but not anthropometric markers of health-related variables. J Appl Physiol. 2000;89:636-643.
14. Carroll JF, Chiapa AL, Rodriquez M, et al. Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity. 2008;16:600-607.
15. Bray GA, Jablonski KA, Fujimoto WY, et al.; Diabetes Prevention Program Research Group. Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program. Am J Clin Nutr. 2008;87:1212-1218.
16. Goran MI, Nagy TR, Treuth MS, et al. Visceral fat in white and African-American prepubertal children. Am J Clin Nutr. 1997;65:1703-1708.
17. Huang TT, Johnson MS, Figueroa-Colon R, et al. Growth of visceral fat, subcutaneous abdominal fat, and total body fat in children. Obes Res. 2001;9:283-289.
18. Owens S, Gutin B, Barbeau P, et al. Visceral adipose tissue and markers of the insulin resistance syndrome in obese black and white teenagers. Obes Res. 2000;8:287-293.
19. Randall OS, Retta TM, Kwagyan J, et al. Obese African Americans: the prevalence of dyslipidemia, hypertension and diabetes mellitus. Ethn Dis. 2004;14:384-388.
20. Aguilar-Salinas CA, García EG, Robles L, et al. High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab. 2008;93:4075-4079.
21. Karelis AD, Brochu M, Rabasa-Lhoret R. Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab. 2004;30:569-57.
22. Dempster P, Aitkens S. A new air displacement method for the determination of human body composition. Med Sci Sports Exerc. 1995;27:1692-1697.
23. Calle EE, Thun MJ, Petrelli JM, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097-1105.
24. Peter WF, Wilson RB, D'Agostino LS, et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867-1872.
25. Kraja AT, Borecki IB, North K, et al. Longitudinal and age trends of metabolic syndrome and its risk factors: the Family Heart Study. Nutr Metab (Lond). 2006;3:41.
26. Messier V, Karelis AD, Robillard M, et al. Metabolically healthy but obese individuals: relationship with hepatic enzymes. Metab Clin Exp. 2010;59:20-24.
27. Ferrannini E, Natali A, Bell P, et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest. 1997;100:1166-1173.
28. Karelis AD, Faraj M, Bastard JP, et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90:4145-4150.
29. Karelis AD, Rabasa-Lhoret R. Inclusion of C-reactive protein in the identification of metabolically healthy but obese (MHO) individuals. Diabetes Metab. 2008;34:183-184.
30. Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism. 2001;50:1499-1504.
31. Lemieux S, Després JP. Metabolic complications of visceral obesity: contribution to the etiology of type 2 diabetes and implications for prevention and treatment. Diabetes Metab. 1994;20:375-393.
32. Després JP, Lemieux I, Prud'homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ. 2001;322:716-720.
33. Lemieux I, Drapeau V, Richard D, et al. Waist girth does not predict metabolic complications in severely obese men. Diabetes Care. 2006;29:1417-1419.
34. Drapeau V, Lemieux I, Richard D, et al. Waist circumference is useless to assess the prevalence of metabolic abnormalities in severely obese women. Obes Surg. 2007;17:905-909.
35. Lakka HM, Lakka TA, Tuomilehto J, et al. Abdominal obesity is associated with increased risk of acute coronary events in men. Eur Heart J. 2002;23:706-713.
36. Price GM, Uauy R, Breeze E, et al. Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. Am J Clin Nutr. 2006;84:449-460.
37. Gelber RP, Gaziano JM, Orav EJ, et al. Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol. 2008;52:605-615.
38. Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women aged 18-79years. J Chronic Dis. 1987;40:421-428.
39. Freedman DS, Srinivasan SR, Harsha DW, et al. Relation of body fat patterning to lipid and lipoprotein concentrations in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr. 1989;50:930-939.