Presence of high-ERG expression is an independent unfavorable prognostic marker in MLL-rearranged childhood myeloid leukemia

Blood

Volumn 119, Issue 4, 2012, Pages 1086-1087

  Pigazzi, Martina ^a   Masetti, Riccardo ^b   Martinolli, Francesco ^a   Manara, Elena ^a   Beghin, Alessandra ^a   Rondelli, Roberto ^b   Locatelli, Franco ^c   Fagioli, Franca ^d   Pession, Andrea ^b   Basso, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; CHILDHOOD LEUKEMIA; ERG GENE; GENE; GENE EXPRESSION; GENE REARRANGEMENT; LETTER; PRIORITY JOURNAL;

EID: 84856296104     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-10-385815     Document Type: Letter

References (8)

1. Balgobind BV, Hollink IH, Arentsen-Peters ST, et al. Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia. Haematologica. 2011;96(10):1478-1487.
2. Martens JH. Acute myeloid leukemia: a central role for the ETS factor ERG. Int J Biochem Cell Biol. 2011;43(10):1413-1416.
3. Marcucci G, Baldus CD, Ruppert AS, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23(36):9234-9242.
4. Baldus CD, Burmeister T, Martus P, et al. High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J Clin Oncol. 2006;24(29):4714-4720. (Pubitemid 46630935)
5. Staffas A, Kanduri M, Hovland R, et al. Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia. Blood. 2011;118(22):5905-5913.
6. Pession A, C. R., MC. P, et al. Results of the AIEOP AML 2002/01 Study for treatment of children with acute myeloid leukemia. 51st ASH annual meeting and exposition. Orlando, FL. Blood. 2009;114: Abstract 17.
7. Balgobind BV, Raimondi SC, Harbott J, et al. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood. 2009;114(12):2489-2496.
8. Pigazzi M, Masetti R, Bresolin S, et al. MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study. Leukemia. 2011;25(3):560-563.