S100A6 protein negatively regulates cacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Ning, Xiaoxuan ^a   Sun, Shiren ^a   Zhang, Kun ^b   Liang, Jie ^a   Chuai, Yucai ^a   Li, Yuan ^a   Wang, Xiaoming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b SHAANXI NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BINDING PROTEIN; CALCYCLIN; CALCYCLIN BINDING PROTEIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN LEF; PROTEIN S 100; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; CACYBP PROTEIN, HUMAN; CALCIUM BINDING PROTEIN; CELL CYCLE PROTEIN; S100A6 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MKN45; CONTROLLED STUDY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STOMACH CANCER; STOMACH CARCINOGENESIS; TRANSCRIPTION INITIATION; TUMOR VOLUME; UBIQUITINATION; WILD TYPE; ANIMAL; CHEMISTRY; GENE DELETION; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; STOMACH TUMOR; TUMOR CELL LINE;

EUKARYOTA;

ANIMALS; BETA CATENIN; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; MICE; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; S100 PROTEINS; SEQUENCE DELETION; STOMACH NEOPLASMS;

EID: 84856292997     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030185     Document Type: Article

References (42)

1. Heizmann CW, Fritz G, Schafer BW, (2002) S100 proteins: structure, functions and pathology. Front Biosci 7: 1356-1368.
2. Van Dieck J, Brandt T, Teufel DP, Veprintsev DB, Joerger AC, et al. (2010) Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73. Oncogene 29: 2024-2035.
3. Shimamoto S, Kubota Y, Tokumitsu H, Kobayashi R, (2010) S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett 584: 1119-1125.
4. Schafer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW, (1995) Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 protein family. Genomics 25: 638-643.
5. Schafer BW, Heizmann CW, (1996) The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 21: 134-140.
6. Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, et al. (2006) S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc Natl Acad Sci USA 103: 14825-14830.
7. Donato R, (1999) Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta 1450: 191-231.
8. Filipek A, Kuznicki J, (1998) Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin. J Neurochem 70: 1793-1798.
9. Zhao Y, You H, Liu F, An H, Shi Y, et al. (2002) Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells. Cancer Lett 185: 211-216.
10. Zhai H, Shi Y, Yu J, Hong L, Tang H, et al. (2006) Establishment and characterization of calcyclin binding protein (CacyBP) monoclonal antibody. Hybridoma 25: 91-94.
11. Sun SR, Ning XX, Liu J, Liu LL, Chen Y, et al. (2007) Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. Biochem Biophys Res Commun 356: 864-871.
12. Ning XX, Sun SR, Liu LL, Liang J, Han S, et al. (2007) Calcyclin binding protein inhibits proliferation, tumorigenicity and invasion of gastric cancer. Mol Cancer Res 5: 1254-1262.
13. Filipek A, Jastrzebska B, Nowotny M, Kuznicki J, (2002) CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. J Biol Chem 277: 28848-28852.
14. Filipek A, Michowski W, Kuznicki J, (2008) Involvement of S100A6 (calcyclin) and its binding partners in intracellular signaling pathways. Adv Enzyme Regul 48: 225-239.
15. Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, et al. (2005) The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies. Biochemistry 44: 9462-9471.
16. Schneider G, Filipek A, (2011) S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function. Amino Acids 41: 773-780.
17. Lai RH, Hsiao YW, Wang MJ, Lin HY, Wu CW, et al. (2010) SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation. Cancer Lett 288: 75-85.
18. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, et al. (1997) Constitutive transcriptional activation by a b-catenin-Tcf complex in APC-/- colon carcinoma. Science 275: 1784-1787.
19. Cho YG, Nam SW, Kim TY, Kim YS, Kim CJ, et al. (2003) Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer. APMIS 111: 539-545.
20. Mori M, Shimada H, Gunji Y, Matsubara H, Hayashi H, et al. (2004) S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. Oncol Rep 11: 1287-1293.
21. Shyu RY, Huang SL, Jiang SY, (2003) Retinoic acid increases expression of the calcium-binding protein S100P in human gastric cancer cells. J Biomed Sci 10: 313-319.
22. Ohuchida K, Mizumoto K, Ishikawa N, Fujii K, Konomi H, et al. (2005) The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Clin Cancer Res 11: 7785-7793.
23. Leśniak W, Słomnicki ŁP, Filipek A, (2009) S100A6- new facts and features. Biochem Biophys Res Commun 390: 1087-1092.
24. Anna Filipek (2006) S100A6 and CacyBP/SIP - Two Proteins Discovered in Ehrlich Ascites Tumor Cells That Are Potentially Involved in the Degradation of β -Catenin. Chemotherapy 52: 32-34.
25. Matsuzawa SI, Reed JC, (2001) Siah-1, SIP and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 7: 915-926.
26. Lee YT, Dimitrova YN, Schneider G, Ridenour WB, Bhattacharya S, et al. (2008) Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry 47: 10921-10932.
27. Santelli E, Leone M, Li C, Fukushima T, Preece NE, et al. (2005) Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem 280: 34278-34287.
28. Martensson A, Oberg A, Jung A, Cederquist K, Stenling R, et al. (2007) Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep 17: 447-452.
29. Saadeddin A, Babaei-Jadidi R, Spencer-Dene B, Nateri AS, (2009) The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Mol Cancer Res 7: 1189-1196.
30. Kolligs FT, Bommer G, Göke B, (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66: 131-144.
31. Ye YW, Wu JH, Wang CM, Zhou Y, Du CY, et al. (2011) Sox17 regulates proliferation and cell cycle during gastric cancer progression. Cancer Lett 307: 124-131.
32. Fukushima T, Zapata JM, Singha NC, Thomas M, Kress CL, et al. (2006) Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint. Immunity 24: 29-39.
33. Van Dieck J, Brandt T, Teufel DP, Veprintsev DB, Joerger AC, et al. (2010) Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73. Oncogene 29: 2024-2035.
34. Santamaria-Kisiel L, Rintala-Dempsey AC, Shaw GS, (2006) Calcium-dependent and-independent interactions of the S100 protein family. Biochem J 396: 201-214.
35. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, et al. (2003) Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. J Biol Chem 278: 26923-26928.
36. Filipek A, Michowski W, Kuznicki J, (2008) Involvement of S100A6 (calcyclin) and its binding partners in intracellular signaling pathways. Adv Enzyme Regul 48: 225-239.
37. Lustig B, Behrens J, (2003) The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 129: 199-221.
38. Kilanczyk E, Filipek S, Jastrzebska B, Filipek A, (2009) CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1. Biochem Biophys Res Commun 380: 54-59.
39. Filipek A, Schneider G, Mietelska A, Figiel I, Niewiadomska G, (2008) Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein. J Neural Transm 115: 1257-1264.
40. Schneider G, Nieznanski K, Kilanczyk E, Bieganowski P, Kuznicki J, et al. (2007) CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies. Biochim Biophys Acta 1773: 1628-1636.
41. Schneider G, Nieznanski K, Jozwiak J, Slomnicki LP, Redowicz MJ, et al. (2010) Tubulin binding protein, CacyBP/SIP, induces actin polymerization and may link actin and tubulin cytoskeletons. Biochim Biophys Acta 1803: 1308-1317.
42. Meng F, Dong B, Li H, Fan D, Ding J, (2009) RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer. Cancer Biol Ther 8: 174-179.