The elements of human cyclin D1 promoter and regulation involved

Clinical Epigenetics

Volumn 2, Issue 2, 2011, Pages 63-76

  Guo, Zhi Yi ^a   Hao, Xiao Hui ^a   Tan, Fei Fei ^a   Pei, Xin ^a   Shang, Li Mei ^a   Jiang, Xue Lian ^a   Yang, Fang ^a  

^a HEBEI UNITED UNIVERSITY   (China)

Author keywords

Epigenetic regulation; Promoter; Signal transduction pathway; Transcription factor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; BETA CATENIN; BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; EARLY GROWTH RESPONSE FACTOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCTAMER TRANSCRIPTION FACTOR 1; PROTEIN ARE; PROTEIN CSL; PROTEIN CYCY; PROTEIN E BOX; PROTEIN GAS; PROTEIN GT BOX; PROTEIN TCF4; STAT3 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

EID: 84856281317     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1007/s13148-010-0018-y     Document Type: Review

References (186)

1. Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A, Harel-Bellan A (2004) A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. EMBO J 23:605-615 (Pubitemid 38282392)
2. Alao JP (2007) The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6:24
3. Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, Vigushin DM (2006a) The cyclin D1 protooncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer 5:7
4. Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM (2006b) Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer 5:8
5. Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG (1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 270:23589-23597
6. Albanese C, D'Amico M, Reutens AT, Fu M, Watanabe G, Lee RJ, Kitsis RN, Henglein B, Avantaggiati M, Somasundaram K et al (1999) Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis. J Biol Chem 274:34186-34195 (Pubitemid 129511756)
7. Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben-Ze'ev A et al (2003) IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 14:585-599 (Pubitemid 36237018)
8. Allan AL, Albanese C, Pestell RG, LaMarre J (2001) Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes. J Biol Chem 276:27272-27280
9. Artavanis-Tsakonas S, RandMD, Lake RJ (1999)Notch signaling: cell fate control and signal integration in development. Science 284:770-776 (Pubitemid 29291335)
10. Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M (2000) Cell cycledependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J 19:2056-2068 (Pubitemid 30237581)
11. Balmanno K, Cook SJ (1999) Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 18:3085-3097 (Pubitemid 29261229)
12. Bauerfeld CP, Hershenson MB, Page K (2001) Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes. Am J Physiol Lung Cell Mol Physiol 280:L974-L982
13. Behrens J (2000) Control of beta-catenin signaling in tumor development. Ann NY Acad Sci 910:21-33, discussion 33-25
14. Bennett AM, Tonks NK (1997) Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science 278:1288-1291 (Pubitemid 27495740)
15. Bennett LB, Schnabel JL, Kelchen JM, Taylor KH, Guo J, Arthur GL, Papageorgio CN, Shi H, Caldwell CW (2009) DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma. Genes Chromosom Cancer 48:828-841
16. Bhalla US, Ram PT, Iyengar R (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297:1018-1023 (Pubitemid 34856036)
17. Bienvenu F, Barre B, Giraud S, Avril S, Coqueret O (2005) Transcriptional regulation by a DNA-associated form of cyclin D1. Mol Biol Cell 16(4):1850-1858 (Pubitemid 40471954)
18. Boulon S, Dantonel JC, Binet V, Vie A, Blanchard JM, Hipskind RA, Philips A (2002) Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB-and CREB binding protein-independent mechanism. Mol Cell Biol 22:7769-7779 (Pubitemid 35217288)
19. Brabletz T, Jung A, Dag S, Hlubek F, Kirchner T (1999) Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 155:1033-1038 (Pubitemid 29488909)
20. Brabletz T, Herrmann K, Jung A, Faller G, Kirchner T (2000) Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol 156:865-870 (Pubitemid 30626945)
21. Brockman JL, Schroeder MD, Schuler LA (2002) PRL activates the cyclin D1 promoter via the Jak2/Stat pathway. Mol Endocrinol 16:774-784 (Pubitemid 34297746)
22. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr (1999) Stat3 as an oncogene. Cell 98:295-303 (Pubitemid 29380565)
23. Brown JR, Nigh E, Lee RJ, Ye H, Thompson MA, Saudou F, Pestell RG, Greenberg ME (1998) Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol 18:5609-5619 (Pubitemid 28388143)
24. Burch PM, Yuan Z, Loonen A, Heintz NH (2004) An extracellular signal-regulated kinase 1-and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry. Mol Cell Biol 24:4696-4709 (Pubitemid 38668037)
25. Calo V, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N, Russo A (2003) STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol 197:157-168 (Pubitemid 37485244)
26. Catalano A, Caprari P, Rodilossi S, Betta P, Castellucci M, Casazza A, Tamagnone L, Procopio A (2004) Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation. FASEB J 18:358-360
27. Chen L, Zeng Y, Yang H, Lee TD, French SW, Corrales FJ, Garcia-Trevijano ER, Avila MA, Mato JM, Lu SC (2004) Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J 18:914-916
28. Chien J, Narita K, Rattan R, Giri S, Shridhar R, Staub J, Beleford D, Lai J, Roberts LR, Molina J et al (2008) A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. Oncogene 27:7223-7234
29. Chu M, Guo J, Chen CY (2005) Long-term exposure to nicotine, via ras pathway, induces cyclin D1 to stimulate G1 cell cycle transition. J Biol Chem 280:6369-6379 (Pubitemid 40341183)
30. Cicatiello L, Addeo R, Sasso A, Altucci L, Petrizzi VB, Borgo R, Cancemi M, Caporali S, Caristi S, Scafoglio C et al (2004) Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. Mol Cell Biol 24:7260-7274 (Pubitemid 39014451)
31. Civenni G, Holbro T, Hynes NE (2003) Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells. EMBO Rep 4:166-171 (Pubitemid 36322158)
32. Clark JA, Black AR, Leontieva OV, Frey MR, Pysz MA, Kunneva L, Woloszynska-Read A, Roy D, Black JD (2004) Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells. J Biol Chem 279:9233-9247 (Pubitemid 38295987)
33. Coqueret O (2002) Linking cyclins to transcriptional control. Gene 299:35-55 (Pubitemid 35379826)
34. D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K et al (2000) The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMPresponsive element-binding protein-dependent pathways. J Biol Chem 275:32649-32657
35. D'Amico M, Wu K, Fu M, Rao M, Albanese C, Russell RG, Lian H, Bregman D, White MA, Pestell RG (2004) The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements. Cancer Res 64:4122-4130 (Pubitemid 38802414)
36. Dominguez G, Carballido J, Silva J, Silva JM, Garcia JM, Menendez J, Provencio M, Espana P, Bonilla F (2002) p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients. Clin Cancer Res 8:980-985 (Pubitemid 35177345)
37. Ellinger-Ziegelbauer H, Kelly K, Siebenlist U (1999) Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3. Mol Cell Biol 19:3857-3868 (Pubitemid 29193845)
38. Esufali S, Bapat B (2004) Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 23:8260-8271 (Pubitemid 39531837)
39. Eto I (2000) Molecular cloning and sequence analysis of the promoter region of mouse cyclin D1 gene: implication in phorbol esterinduced tumour promotion. Cell Prolif 33:167-187 (Pubitemid 30616163)
40. Fan J, Bertino JR (1997) Functional roles of E2F in cell cycle regulation. Oncogene 14:1191-1200 (Pubitemid 27141921)
41. Fassett JT, Tobolt D, Nelsen CJ, Albrecht JH, Hansen LK (2003) The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J Biol Chem 278:31691-31700 (Pubitemid 37048348)
42. Fox KE, Colton LA, Erickson PF, Friedman JE, Cha HC, Keller P, MacDougald OA, Klemm DJ (2008) Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation. J Biol Chem 283:35096-35105
43. Fu M, Wang C, Li Z, Sakamaki T, Pestell RG (2004) Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145:5439-5447 (Pubitemid 39564581)
44. Gille H, Downward J (1999) Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem 274:22033-22040
45. Gonzalez-Mariscal L, Tapia R, Huerta M, Lopez-Bayghen E (2009) The tight junction protein ZO-2 blocks cell cycle progression and inhibits cyclin D1 expression. Ann NY Acad Sci 1165:121-125
46. Gotoh J, Obata M, Yoshie M, Kasai S, Ogawa K (2003) Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis. Carcinogenesis 24:435-442 (Pubitemid 36432638)
47. Graham NA, Asthagiri AR (2004) Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells. J Biol Chem 279:23517-23524 (Pubitemid 38685664)
48. Greulich H, Erikson RL (1998) An analysis of Mek1 signaling in cell proliferation and transformation. J Biol Chem 273:13280-13288 (Pubitemid 28246901)
49. Grosch S, Tegeder I, Schilling K, Maier TJ, Niederberger E, Geisslinger G (2003) Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FASEB J 17:1316-1318
50. Grueneberg DA, Pablo L, Hu KQ, August P, Weng Z, Papkoff J (2003) A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the betacatenin signaling pathway. Mol Cell Biol 23:3936-3950 (Pubitemid 36597472)
51. Guillemot L, Levy A, Raymondjean M, Rothhut B (2001) Angiotensin II-induced transcriptional activation of the cyclin D1 gene is mediated by Egr-1 in CHO-AT(1A) cells. J Biol Chem 276:39394-39403 (Pubitemid 37371317)
52. Guo Y, Harwalkar J, Stacey DW, Hitomi M (2005) Destabilization of cyclin D1 message plays a critical role in cell cycle exit upon mitogen withdrawal. Oncogene 24:1032-1042 (Pubitemid 40313880)
53. Guo Z, Wang J, Yang J, Wu NH, Zhang Y, Shen YF (2009) An inhibitory role of p53 via NF-kappaB element on the cyclin D1 gene under heat shock. Biochim Biophys Acta 1789:758-762
54. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr (1999) NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19:5785-5799 (Pubitemid 29339933)
55. Hamelers IH, van Schaik RF, Sipkema J, Sussenbach JS, Steenbergh PH (2002) Insulin-like growth factor I triggers nuclear accumulation of cyclin D1 in MCF-7 S breast cancer cells. J Biol Chem 277:47645-47652 (Pubitemid 36159286)
56. Hashiguchi Y, Tsuda H, Yamamoto K, Inoue T, Ishiko O, Ogita S (2001) Combined analysis of p53 and RB pathways in epithelial ovarian cancer. Hum Pathol 32:988-996 (Pubitemid 32911323)
57. Herber B, Truss M, Beato M, Muller R (1994a) Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:1295-1304 (Pubitemid 24095043)
58. Herber B, Truss M, Beato M, Muller R (1994b) Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:2105-2107
59. Hervouet E, Vallette FM, Cartron PF (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4:487-499
60. Hilton TL, Li Y, Dunphy EL, Wang EH (2005) TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter. Mol Cell Biol 25:4321-4332 (Pubitemid 40617676)
61. Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M (1999) NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19:2690-2698 (Pubitemid 29144513)
62. Holnthoner W, Pillinger M, Groger M, Wolff K, Ashton AW, Albanese C, Neumeister P, Pestell RG, Petzelbauer P (2002) Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem 277:45847-45853 (Pubitemid 35417563)
63. Hsiang CH, Straus DS (2002) Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells. Oncogene 21:2212-2226 (Pubitemid 34311375)
64. Hulit J, Bash T, Fu M, Galbiati F, Albanese C, Sage DR, Schlegel A, Zhurinsky J, Shtutman M, Ben-Ze'ev A et al (2000) The cyclin D1 gene is transcriptionally repressed by caveolin-1. J Biol Chem 275:21203-21209 (Pubitemid 30481815)
65. Hutter G, Scheubner M, Zimmermann Y, Kalla J, Katzenberger T, Hubler K, Roth S, Hiddemann W, Ott G, Dreyling M (2006) Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphoma. Genes Chromosom Cancer 45:203-210 (Pubitemid 43191027)
66. Ilnytskyy Y, Zemp FJ, Koturbash I, Kovalchuk O (2008) Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun 377:41-45
67. Inoshita S, Terada Y, Nakashima O, Kuwahara M, Sasaki S, Marumo F (1999) Roles of E2F1 in mesangial cell proliferation in vitro. Kidney Int 56:2085-2095 (Pubitemid 30004737)
68. Janssen JW, Imoto I, Inoue J, Shimada Y, Ueda M, Imamura M, Bartram CR, Inazawa J (2002) MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. J Hum Genet 47:460-464 (Pubitemid 34988280)
69. Jeffries S, Robbins DJ, Capobianco AJ (2002) Characterization of a high-molecular-weight Notch complex in the nucleus of Notch (ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol 22:3927-3941 (Pubitemid 34525231)
70. Jirmanova L, Afanassieff M, Gobert-Gosse S, Markossian S, Savatier P (2002) Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21:5515-5528 (Pubitemid 34983541)
71. Jones SM, Kazlauskas A (2001) Growth factor-dependent signaling and cell cycle progression. FEBS Lett 490:110-116 (Pubitemid 32171929)
72. Joyce D, Bouzahzah B, Fu M, Albanese C, D'Amico M, Steer J, Klein JU, Lee RJ, Segall JE, Westwick JK et al (1999) Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem 274:25245-25249
73. Jung C, Kim RS, Lee SJ, Wang C, Jeng MH (2004) HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Cancer Res 64:3046-3051 (Pubitemid 38581403)
74. Kabotyanski EB, Rosen JM (2003) Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. J Biol Chem 278:17218-17227 (Pubitemid 36799603)
75. Kawanaka H, Tomikawa M, Baatar D, Jones MK, Pai R, Szabo IL, Sugimachi K, Sarfeh IJ, Tarnawski AS (2001) Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Life Sci 69:3019-3033 (Pubitemid 33044696)
76. Kawauchi S, Liu XP, Kawasaki K, Hirakawa T, Amada S, Furuya T, Oga A, Sasaki K (2004) Significance of beta-catenin and pRB pathway components in malignant ovarian germ cell tumours: INK4A promoter CpG island methylation is associated with cell proliferation. J Pathol 204:268-276 (Pubitemid 39430085)
77. Kijima T, Niwa H, Steinman RA, Drenning SD, Gooding WE, Wentzel AL, Xi S, Grandis JR (2002) STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ 13:355-362
78. Kikuchi A (2000) Regulation of beta-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 268:243-248 (Pubitemid 30119606)
79. Kim AL, Gautier J, Bickers DR, Athar M (2002) Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas. Biochem Biophys Res Commun 298:377-382 (Pubitemid 35333716)
80. Kintscher U, Bruemmer D, Blaschke F, Unger T, Law RE (2003) p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells. Biochem Biophys Res Commun 305:552-556 (Pubitemid 36579266)
81. Kitazawa S, Kitazawa R, Maeda S (1999) Transcriptional regulation of rat cyclin D1 gene by CpG methylation status in promoter region. J Biol Chem 274:28787-28793
82. Klein A, Guhl E, Tzeng YJ, Fuhrhop J, Levrero M, Graessmann M, Graessmann A (2003) HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53. Oncogene 22:2910-2919 (Pubitemid 36648917)
83. Knezevic D, Brash DE (2004) Role of E2F1 in apoptosis: a case study in feedback loops. Cell Cycle 3:729-732 (Pubitemid 40187900)
84. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT et al (2004) Mouse development and cell proliferation in the absence of D-cyclins. Cell 118:477-491 (Pubitemid 39485667)
85. Krieger S, Grunau C, Sabbah M, Sola B (2005) Cyclin D1 gene activation in human myeloma cells is independent of DNA hypomethylation or histone hyperacetylation. Exp Hematol 33:652-659 (Pubitemid 40725831)
86. Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME (2003) A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114:323-334 (Pubitemid 36962931)
87. Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA (2009) Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS ONE 4:e5711
88. Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271:20608-20616 (Pubitemid 26281839)
89. Lee RJ, Albanese C, Stenger RJ, Watanabe G, Inghirami G, Haines GK 3rd, Webster M, Muller WJ, Brugge JS, Davis RJ, Pestell RG (1999) pp 60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signalregulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. J Biol Chem 274:7341-7350
90. Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, Haines GK 3rd, Siegel PM, Hung MC, Yarden Y et al (2000) Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 20:672-683 (Pubitemid 30023109)
91. Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA (2004) Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 5:91-102 (Pubitemid 38121599)
92. Leshchenko VV, Kuo PY, Shaknovich R, Yang DT, Gellen T, Petrich A, Yu Y, Remache Y, Weniger MA, Rafiq S et al (2010) Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma. Blood 116(7):1025-1034
93. Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C et al (2006) Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 66:2544-2552
94. Lin HM, Pestell RG, Raz A, Kim HR (2002) Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. Oncogene 21:8001-8010 (Pubitemid 35430611)
95. Liu H, Wang J, Epner EM (2004) Cyclin D1 activation in B-cell malignancy: association with changes in histone acetylation, DNA methylation, and RNA polymerase II binding to both promoter and distal sequences. Blood 104:2505-2513 (Pubitemid 39331854)
96. Liu H, Huang J, Wang J, Jiang S, Bailey AS, Goldman DC, Welcker M, Bedell V, Slovak ML, Clurman B et al (2008a) Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma. J Exp Med 205:1843-1858
97. Liu T, Niu Y, Feng Y, Niu R, Yu Y, Lv A, Yang Y (2008b) Methylation of CpG islands of p16(INK4a) and cyclinD1 overexpression associated with progression of intraductal proliferative lesions of the breast. Hum Pathol 39:1637-1646
98. Magne S, Caron S, Charon M, Rouyez MC, Dusanter-Fourt I (2003) STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. Mol Cell Biol 23:8934-8945 (Pubitemid 37499784)
99. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S, Dubus P, Barbacid M (2004) Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118:493-504 (Pubitemid 39485668)
100. Marampon F, Casimiro MC, Fu M, Powell MJ, Popov VM, Lindsay J, Zani BM, Ciccarelli C, Watanabe G, Lee RJ, Pestell RG (2008) Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factorkappaB. Mol Biol Cell 19:2566-2578
101. Marino M, Acconcia F, Trentalance A (2003) Biphasic estradiolinduced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells. Mol Biol Cell 14:2583-2591 (Pubitemid 36724344)
102. Martin V, Valencia A, Agirre X, Cervera J, San Jose-Eneriz E, Vilas-Zornoza A, Rodriguez-Otero P, Sanz MA, Herrera C, Torres A et al (2009) Epigenetic regulation of the noncanonical Wnt pathway in acute myeloid leukemia. Cancer Sci 101:425-432
103. Masuda M, Suzui M, Weinstein IB (2001) Effects of epigallocatechin-3- gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res 7:4220-4229 (Pubitemid 34044648)
104. Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S, Weinstein IB (2002) Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62:3351-3355 (Pubitemid 34651376)
105. Matsuda Y (2008) Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma. World J Gastroenterol 14:1734-1740 (Pubitemid 351493379)
106. Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG, Kanakura Y (1999) Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 18:1367-1377 (Pubitemid 29110320)
107. McMahon C, Suthiphongchai T, DiRenzo J, Ewen ME (1999) P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor. Proc Natl Acad Sci USA 96:5382-5387 (Pubitemid 29234626)
108. Mechta F, Lallemand D, Pfarr CM, Yaniv M (1997) Transformation by ras modifies AP1 composition and activity. Oncogene 14:837-847 (Pubitemid 27100028)
109. Morin PJ (1999) beta-catenin signaling and cancer. Bioessays 21:1021-1030
110. Motokura T, Arnold A (1993) PRAD1/cyclin D1 proto-oncogene: genomic organization, 5′ DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosom Cancer 7:89-95 (Pubitemid 23163655)
111. Muller H, Moroni MC, Vigo E, Petersen BO, Bartek J, Helin K (1997) Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol 17:5508-5520 (Pubitemid 27357647)
112. Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E et al (2004) Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol 24:2890-2904 (Pubitemid 38381278)
113. Mulloy R, Salinas S, Philips A, Hipskind RA (2003) Activation of cyclin D1 expression by the ERK5 cascade. Oncogene 22:5387-5398 (Pubitemid 37072193)
114. Musa NL, Ramakrishnan M, Li J, Kartha S, Liu P, Pestell RG, Hershenson MB (1999) Forskolin inhibits cyclin D1 expression in cultured airway smooth-muscle cells. Am J Respir Cell Mol Biol 20:352-358 (Pubitemid 129504897)
115. Nagata D, Suzuki E, Nishimatsu H, Satonaka H, Goto A, Omata M, Hirata Y (2001) Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells. J Biol Chem 276:662-669 (Pubitemid 32050363)
116. Nheu T, He H, Hirokawa Y, Walker F, Wood J, Maruta H (2004) PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle 3:71-74 (Pubitemid 40268591)
117. Oktay M, Wary KK, Dans M, Birge RB, Giancotti FG (1999) Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol 145:1461-1469 (Pubitemid 29310003)
118. Page K, Li J, Hershenson MB (1999a) Platelet-derived growth factor stimulation of mitogen-activated protein kinases and cyclin D1 promoter activity in cultured airway smooth-muscle cells. Role of Ras. Am J Respir Cell Mol Biol 20:1294-1302 (Pubitemid 129503248)
119. Page K, Li J, Hodge JA, Liu PT, Vanden Hoek TL, Becker LB, Pestell RG, Rosner MR, Hershenson MB (1999b) Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J Biol Chem 274:22065-22071
120. Page K, Li J, Wang Y, Kartha S, Pestell RG, Hershenson MB (2000) Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells. Am J Respir Cell Mol Biol 23:436-443
121. Page K, Li J, Hershenson MB (2001) p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 280:L955-L964
122. Page K, Li J, Corbit KC, Rumilla KM, Soh JW, Weinstein IB, Albanese C, Pestell RG, Rosner MR, Hershenson MB (2002) Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol 27:204-213 (Pubitemid 34780800)
123. Paramio JM, Navarro M, Segrelles C, Gomez-Casero E, Jorcano JL (1999) PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 18:7462-7468 (Pubitemid 30035047)
124. Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S (2001a) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 276:27462-27469
125. Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S (2001b) Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol 153:1161-1174
126. Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ, Arnold A (1999) The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20:501-534 (Pubitemid 30647078)
127. Philipp A, Schneider A, Vasrik I, Finke K, Xiong Y, Beach D, Alitalo K, Eilers M (1994) Repression of cyclin D1: a novel function of MYC. Mol Cell Biol 14:4032-4043 (Pubitemid 24160809)
128. Pierce AM, Fisher SM, Conti CJ, Johnson DG (1998a) Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene 16:1267-1276 (Pubitemid 28138199)
129. Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (1998b) Differential activities of E2F family members: unique functions in regulating transcription. Mol Carcinog 22:190-198 (Pubitemid 28348021)
130. Pradeep A, Sharma C, Sathyanarayana P, Albanese C, Fleming JV, Wang TC, Wolfe MM, Baker KM, Pestell RG, Rana B (2004) Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene 23:3689-3699 (Pubitemid 38658436)
131. Pruitt K, Pruitt WM, Bilter GK, Westwick JK, Der CJ (2002) Rafindependent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation. J Biol Chem 277:31808-31817 (Pubitemid 34968987)
132. Qin L, Li X, Ko JK, Partridge NC (2005) Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase. J Biol Chem 280:3104-3111 (Pubitemid 40189421)
133. Quintanilla-Martinez L, Kremer M, Specht K, Calzada-Wack J, Nathrath M, Schaich R, Hofler H, Fend F (2003) Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. Am J Pathol 162:1449-1461 (Pubitemid 36512827)
134. Ramakrishnan M, Musa NL, Li J, Liu PT, Pestell RG, Hershenson MB (1998) Catalytic activation of extracellular signal-regulated kinases induces cyclin D1 expression in primary tracheal myocytes. Am J Respir Cell Mol Biol 18:736-740 (Pubitemid 128358419)
135. Recio JA, Merlino G (2002) Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1. Oncogene 21:1000-1008 (Pubitemid 34174512)
136. Rocha S, Martin AM, Meek DW, Perkins ND (2003) p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1. Mol Cell Biol 23:4713-4727 (Pubitemid 36740458)
137. Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004) The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression. Oncogene 23:8185-8195 (Pubitemid 39531830)
138. Ronchini C, Capobianco AJ (2001) Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 21:5925-5934 (Pubitemid 32737809)
139. Roovers K, Assoian RK (2003) Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol 23:4283-4294 (Pubitemid 36666430)
140. Roovers K, Klein EA, Castagnino P, Assoian RK (2003) Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression. Dev Cell 5:273-284 (Pubitemid 37006471)
141. Ryser S, Massiha A, Piuz I, Schlegel W (2004) Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter. Biochem J 378:473-484 (Pubitemid 38367237)
142. Sabbah M, Courilleau D, Mester J, Redeuilh G (1999) Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element. Proc Natl Acad Sci USA 96:11217-11222 (Pubitemid 29487361)
143. Saito T, Oda Y, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M (2001) beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours. J Pathol 195:222-228 (Pubitemid 32899032)
144. Sampson EM, Haque ZK, Ku MC, Tevosian SG, Albanese C, Pestell RG, Paulson KE, Yee AS (2001) Negative regulation of the Wntbeta-catenin pathway by the transcriptional repressor HBP1. EMBO J 20:4500-4511 (Pubitemid 32772044)
145. Schneider G, Oswald F, Wahl C, Greten FR, Adler G, Schmid RM (2002) Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter. J Biol Chem 277:43599-43607 (Pubitemid 36157774)
146. Shah S, Pishvaian MJ, Easwaran V, Brown PH, Byers SW (2002) The role of cadherin, beta-catenin, and AP-1 in retinoid-regulated carcinoma cell differentiation and proliferation. J Biol Chem 277:25313-25322 (Pubitemid 34951841)
147. Sharma C, Pradeep A, Pestell RG, Rana B (2004) Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes. J Biol Chem 279:16927-16938 (Pubitemid 38560445)
148. Shaulian E, Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390-2400 (Pubitemid 32531297)
149. Shi H, Guo J, Duff DJ, Rahmatpanah F, Chitima-Matsiga R, Al-Kuhlani M, Taylor KH, Sjahputera O, Andreski M, Wooldridge JE, Caldwell CW (2007) Discovery of novel epigenetic markers in non-Hodgkin's lymphoma. Carcinogenesis 28:60-70 (Pubitemid 44942627)
150. Shirato H, Ogawa S, Nakajima K, Inagawa M, Kojima M, Tachibana M, Shinkai Y, Takeuchi T (2009) A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem 284:733-739
151. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'AmicoM, Pestell R, Ben-Ze'ev A (1999) The cyclin D1 gene is a target of the betacatenin/LEF-1 pathway. Proc Natl Acad Sci USA 96:5522-5527 (Pubitemid 29234650)
152. Soh JW, Weinstein IB (2003) Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem 278:34709-34716 (Pubitemid 37553321)
153. Stacey DW (2003) Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol 15:158-163 (Pubitemid 36332190)
154. Stahl M, Ge C, Shi S, Pestell RG, Stanley P (2006) Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Cancer Res 66:7562-7570 (Pubitemid 44289212)
155. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kawaguchi K, Kobayashi C, Iwamoto Y, Tsuneyoshi M (2004) Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma. Cancer Sci 95:651-655 (Pubitemid 39255812)
156. Talarmin H, Rescan C, Cariou S, Glaise D, Zanninelli G, Bilodeau M, Loyer P, Guguen-Guillouzo C, Baffet G (1999) The mitogenactivated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Mol Cell Biol 19:6003-6011 (Pubitemid 29399305)
157. Tashiro E, Maruki H, Minato Y, Doki Y, Weinstein IB, Imoto M (2003) Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway. Cancer Res 63:424-431 (Pubitemid 36152503)
158. Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422-426 (Pubitemid 29180374)
159. Todd DE, Densham RM, Molton SA, Balmanno K, Newson C, Weston CR, Garner AP, Scott L, Cook SJ (2004) ERK1/2 and p38 cooperate to induce a p21(CIP1)-dependent G(1) cell cycle arrest. Oncogene 23:3284-3295 (Pubitemid 38669818)
160. Treinies I, Paterson HF, Hooper S, Wilson R, Marshall CJ (1999) Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis. Mol Cell Biol 19:321-329 (Pubitemid 29018434)
161. Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S (2003) Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278:22374-22378 (Pubitemid 36830287)
162. Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Sekimoto M, Tamura S, Yasuda T, Fujiwara Y, Monden M (2001) Correlation of beta-catenin and cyclin D1 expression in colon cancers. Oncology 61:226-233 (Pubitemid 34701538)
163. Vonlanthen S, Heighway J, Tschan MP, Borner MM, Altermatt HJ, Kappeler A, Tobler A, Fey MF, Thatcher N, Yarbrough WG, Betticher DC (1998) Expression of p16INK4a/p16alpha and p19ARF/p16beta is frequently altered in non-small cell lung cancer and correlates with p53 overexpression. Oncogene 17:2779-2785 (Pubitemid 28554237)
164. Wang Z, Zhang B, Wang M, Carr BI (2003) Persistent ERK phosphorylation negatively regulates cAMP response elementbinding protein (CREB) activity via recruitment of CREBbinding protein to pp 90RSK. J Biol Chem 278:11138-11144 (Pubitemid 36792667)
165. Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG (1996a) Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci USA 93:12861-12866 (Pubitemid 26382734)
166. Watanabe G, Lee RJ, Albanese C, Rainey WE, Batlle D, Pestell RG (1996b) Angiotensin II activation of cyclin D1-dependent kinase activity. J Biol Chem 271:22570-22577 (Pubitemid 26304696)
167. Watanabe G, Albanese C, Lee RJ, Reutens A, Vairo G, Henglein B, Pestell RG (1998) Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol Cell Biol 18:3212-3222 (Pubitemid 28240494)
168. Weber JD, Hu W, Jefcoat SC Jr, Raben DM, Baldassare JJ (1997a) Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem 272:32966-32971 (Pubitemid 28023634)
169. Weber JD, Raben DM, Phillips PJ, Baldassare JJ (1997b) Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 326(Pt 1):61-68 (Pubitemid 27386918)
170. Welch HC, Coadwell WJ, Stephens LR, Hawkins PT (2003) Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett 546:93-97 (Pubitemid 36782287)
171. Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK (2001) Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 3:950-957 (Pubitemid 34428739)
172. Weng LP, Smith WM, Brown JL, Eng C (2001) PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model. Hum Mol Genet 10:605-616 (Pubitemid 32229365)
173. Westerheide SD, Mayo MW, Anest V, Hanson JL, Baldwin AS Jr (2001) The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition. Mol Cell Biol 21:8428-8436 (Pubitemid 33108602)
174. Westwick JK, Lee RJ, Lambert QT, Symons M, Pestell RG, Der CJ, Whitehead IP (1998) Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J Biol Chem 273:16739-16747 (Pubitemid 28311698)
175. Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, Mahon GM, Trzaskos JM, Kay R, Campbell SL, Der CJ (1999) Dependence of Dbl and Dbs transformation on MEK and NFkappaB activation. Mol Cell Biol 19:7759-7770 (Pubitemid 29493440)
176. Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP (2001) Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J 20:3459-3472 (Pubitemid 32634353)
177. Xie Z, Zeng X, Waldman T, Glazer RI (2003) Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 activates beta-catenin and c-Myc, and downregulates caveolin-1. Cancer Res 63:5370-5375 (Pubitemid 37139853)
178. Yan YX, Nakagawa H, Lee MH, Rustgi AK (1997) Transforming growth factor-alpha enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter. J Biol Chem 272:33181-33190 (Pubitemid 28023664)
179. Yan S, Krebs S, Leister KJ, Wenner CE (2000) Perturbation of EGFactivated MEK1 and PKB signal pathways by TGF-beta1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-beta1 in C3H 10 T1/2 cells. J Cell Physiol 185:107-116
180. Yang H, Li TW, Ko KS, Xia M, Lu SC (2009) Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. Hepatology 49:860-870
181. Zhang ZK, Davies KP, Allen J, Zhu L, Pestell RG, Zagzag D, Kalpana GV (2002) Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5. Mol Cell Biol 22:5975-5988 (Pubitemid 34815844)
182. Zhang F, Li C, Halfter H, Liu J (2003) Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22:894-905 (Pubitemid 36255825)
183. Zhao J, Pestell R, Guan JL (2001) Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell 12:4066-4077 (Pubitemid 34001092)
184. Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (2003) Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell 11:1503-1515 (Pubitemid 36776537)
185. Zhou JX, Niehans GA, Shar A, Rubins JB, Frizelle SP, Kratzke RA (2001) Mechanisms of G1 checkpoint loss in resected early stage non-small cell lung cancer. Lung Cancer 32:27-38 (Pubitemid 32224836)
186. Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E (2004) Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem 279:27790-27798 (Pubitemid 38812621)