PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

Biochemical Society Transactions

Volumn 40, Issue 1, 2012, Pages 210-214

  Edwards, Helen V ^a   Scott, John D ^b   Baillie, George S ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cardioprotection; Heat shock protein 20 (Hsp20); Phosphodiesterase type 4 (PDE4); Phosphorylation; Protein kinase A (PKA); Small heat shock protein

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HEAT SHOCK PROTEIN 20;

ADRENERGIC SYSTEM; APOPTOSIS; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; APOPTOSIS; CARDIOMEGALY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEART; HSP20 HEAT-SHOCK PROTEINS; HUMANS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

MUS;

EID: 84856280870     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110673     Document Type: Review

References (29)

1. Tissieres, A., Mitchell, H.K. and Tracy, U.M. (1974) Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J. Mol. Biol. 85, 389-398
2. Qian, J., Ren, X.P., Wang, X.H., Zhang, P.Y., Jones, W.K., Molkentin, J.D., Fan, G.C. and Kranias, E.G. (2009) Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circ. Res. 105, 1223-1231
3. Morimoto, R.I. (1993) Cells in stress: transcriptional activation of heat shock genes. Science 259, 1409-1410
4. Sciandra, J.J. and Subjeck, J.R. (1983) The effects of glucose on protein synthesis and thermostability in Chinese hamster ovary cells. J. Biol. Chem. 258, 12091-12093 (Pubitemid 14229994)
5. Willis, M.S. and Patterson, C. (2010) Hold me tight: role of the heat shock protein family of chaperones in cardiac disease. Circulation 122, 1740-1751
6. Fan, G.C. and Kranias, E.G. (2011) Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. J. Mol. Cell. Cardiol. 51, 574-577
7. Fan, G.C., Chu, G.X. and Kranias, E.G. (2005) Hsp20 and its cardioprotection. Trends Cardiovasc. Med. 15, 138-141
8. Kappe, G., Franck, E., Verschuure, P., Boelens, W.C., Leunissen, J.A.M. and De Jong, W.W. (2003) The human genome encodes 10 α-crystallin-related small heat shock proteins: HspB1-10. Cell Stress Chaperones 8, 53-61 (Pubitemid 36444090)
9. Dreiza, C.M., Komalavilas, P., Furnish, E.J., Flynn, C.R., Sheller, M.R., Smoke, C.C., Lopes, L.B. and Brophy, C.M. (2010) The small heat shock protein, HSPB6, in muscle function and disease. Cell Stress Chaperones 15, 1-11
10. Beall, A., Bagwell, D., Woodrum, D., Stoming, T.A., Kato, K., Suzuki, A., Rasmussen, H. and Brophy, C.M. (1999) The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation. J. Biol. Chem. 274, 11344-11351
11. Rembold, C.M., Foster, D.B., Strauss, J.D., Wingard, C.J. and Van Eyk, J.E. (2000) cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery. J. Physiol. 524, 865-878
12. Flynn, C.R., Komalavilas, P., Tessier, D., Thresher, J., Niederkofler, E.E., Dreiza, C.M., Nelson, R.W., Panitch, A., Joshi, L. and Brophy, C.M. (2003) Transduction of biologically active motifs of the small heat shock-related protein, HSP20, leads to relaxation of vascular smooth muscle. FASEB J. 17, 1358-1360
13. Mudd, J.O. and Kass, D.A. (2008) Tackling heart failure in the twenty-first century. Nature 451, 919-928 (Pubitemid 351301747)
14. El-Armouche, E. and Eschenhagen, T. (2009) β-Adrenergic stimulation and myocardial function in the failing heart. Heart Failure Rev. 14, 225-241
15. Houslay, M.D., Baillie, G.S. and Maurice, D.M. (2007) cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ. Res. 100, 950-966 (Pubitemid 46598920)
16. Baillie, G.S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS J. 276, 1790-1799
17. Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F., Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. J. Mol. Cell. Cardiol. 50, 872-883
18. Welch, E.J., Jones, B.W. and Scott, J.D. (2010) Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol. Interventions 10, 86-97
19. Carnegie, G.K., Soughayer, J., Smith, F.D., Pedroja, B.S., Zhang, F., Diviani, D., Bristow, M.R., Kunkel, M.T., Newton, A.C., Langeberg, L.K. and Scott, J.D. (2008) AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol. Cell 32, 169-179
20. Buja, L.M. (2005) Myocardial ischemia and reperfusion injury. Cardiovasc. Pathol. 14, 170-175
21. Murphy, E. and Steenburgen, C. (2008) Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 88, 581-609 (Pubitemid 351520088)
22. Fan, G.C., Ren, X.P., Qian, J., Yuan, Q.Y., Nicolaou, P., Wang, Y., Jones, W.K., Chu, G.X. and Kranias, E.G. (2005) Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation 111, 1792-1799 (Pubitemid 40525144)
23. Fan, G.C., Chu, G.X., Mitton, B., Song, Q.J., Yuan, Q.Y. and Kranias, E.G. (2004) Small heat-shock protein Hsp20 phosphorylation inhibits β-agonist-induced cardiac apoptosis. Circ. Res. 94, 1474-1482 (Pubitemid 38780320)
24. Gustaffson, A.B. and Gottlieb, R. (2009) Autophagy in ischemic heart disease. Circ. Res. 104, 150-158
25. Nicolaou, P., Knoll, R., Haghighi, K., Fan, G.C., Dorn, G.W., Hasenfuss, G. and Kranias, E.G. (2008) Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. J. Biol. Chem. 283, 33465-33471
26. Fan, G.C., Yuan, Q.Y., Song, G.J., Wang, Y.G., Chen, G.L., Qian, J., Zhou, X.Y., Lee, Y.J., Ashraf, M. and Kranias, E.G. (2006) Small heat-shock protein Hsp20 attenuates β-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ. Res. 99, 1233-1242 (Pubitemid 44808660)
27. Golenhofen, N., Perng, M.D., Quinlan, R.A. and Drenckhahn, D. (2004) Comparison of the small heat shock proteins αB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle. Histochem. Cell Biol. 122, 415-425 (Pubitemid 40379011)
28. Brophy, C.M., Lamb, S. and Graham, A. (1999) The small heat shock-related protein-20 is an actin-associated protein. J. Vasc. Surg. 29, 326-333 (Pubitemid 29085292)
29. Dreiza, C.M., Brophy, C.M., Komalavilas, P., Furnish, E.J., Joshi, L., Pallero, M.A., Murphy-Ullrich, J.E., von Rechenberg, M., Ho, Y.-S. J., Richardson, B. et al. (2005) Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics. FASEB J. 19, 261-263 (Pubitemid 40189275)