Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors

Journal of Biological Chemistry

Volumn 287, Issue 5, 2012, Pages 2963-2970

  Fernández, José A ^a   Skryma, Roman ^b   Bidaux, Gabriel ^b   Magleby, Karl L ^c   Scholfield, C Norman ^d   McGeown, J Graham ^a   Prevarskaya, Natalia ^b   Zholos, Alexander V ^a,e  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Université des Sciences et Technologies de Lille   (France)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d NARESUAN UNIVERSITY   (Thailand)

^e TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM INFLUX; CARBOXAMIDES; CELL SIGNALING; CHANNEL GATING; CHEMICAL INHIBITORS; COEXPRESSED; COMMON FEATURES; COMPLEX REGULATION; ENVIRONMENTAL FACTORS; GATING MECHANISMS; HEK293 CELLS; INCREASED TEMPERATURE; ISOFORMS; MEMBRANE POTENTIALS; SHORT CHANNELS; SINGLE-CHANNEL; SINGLE-CHANNEL ANALYSIS; TRANSIENT RECEPTOR POTENTIALS;

BIOCHEMISTRY; BIOLOGY;

CELLS;

CLOTRIMAZOLE; ISOENZYME; N (4 TERT BUTYLPHENYL) 4 (3 CHLORO 2 PYRIDINYL) 1 PIPERAZINECARBOXAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8 ISOFORM 6; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; HEAT SENSITIVITY; HIGH TEMPERATURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TEMPERATURE SENSITIVITY;

ANTIFUNGAL AGENTS; CLOTRIMAZOLE; HEK293 CELLS; HOT TEMPERATURE; HUMANS; ION CHANNEL GATING; PROTEIN ISOFORMS; PYRAZINES; PYRIDINES; THERMORECEPTORS; TRPM CATION CHANNELS;

EID: 84856278971     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.272823     Document Type: Article

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