Development and evaluation of multiparticulate colon targeted drug delivery system by combine approach of pH and bacteria

International Journal of PharmTech Research

Volumn 3, Issue 2, 2011, Pages 1139-1149

  Kshirsagar, Sanjay J ^a   Bhalekar, Mangesh R ^a   Shukla, Gajendra N ^a   Mohapatra, Santosh K ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

Budesonide; Colonic drug delivery; In vivo study; pH and microbial approach; Polymer

Indexed keywords

BUDESONIDE; EUDRAGIT; GUAR GUM;

ADULT; ARTICLE; COLON; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; INTESTINE TRANSIT TIME; MICROFLORA; NORMAL HUMAN; PELLET EXTRUSION; PH;

EID: 84856261984     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Davis S.S., Overcoming barriers to the oral administration of peptide drugs, Trends Pharm Sci., 1990, 11, 353-355.
2. Vanden Mooter G., Kinget R., Oral colon-specific drug delivery, a review, Drug Delivery., 1995, 2, 81-93.
3. Ashford M., Fell J.T., Targeting drugs to the colon delivery systems for oral administration, J Drug Target., 1994, 2, 241-258.
4. Friend D.R., New oral delivery systems for treatment of inflammatory bowel disease, Adv Drug Del Rev., 2005, 57, 247-265.
5. Fallingborg J., Christensen L.A., Jacobson B.A., Rasmussen S.N., Very low intraluminal colonic pH in patients with active ulcerative colitis, Dig Dis Sci., 1993, 38, 89-93.
6. Sandborn W.J., Phillips S.F., Pathophysiology of symptoms and clinical features of inflammatory bowel disease, 1995, 407-436.
7. Vandamme T.F., Lenourry A., Charrueau C., Chaumeil J.C., The use of polysaccharides to target drugs to the colon, Carbohydrate Polym., 2002, 48,219-231.
8. Evans D.F., Pye G., Bramley R., Clark A.G., Dyson T.J., Hardcastle J.D., Measurement of gastrointestinal pH profiles in normal ambulant human subjects, Gut., 1988, 29, 1035-1041.
9. Keighley MR.B., Arabi Y., Alexander-williams J., Influence of inflammatory bowel disease on intestinal microflora, Gut., 1978, 19, 1099-1106.
10. Watts P.J., Ileum L., Colonic drug delivery, Drug Dev, Ind. Pharm., 1997, 23, 893-913.
11. Sack D.M., Peppercorn M.A., Drug therapy of inflammatory bowel disease. Pharmacotherapy, 1983, 3,158-176.
12. Ashford M., Fell J.T., Attwood D., Sharma H., Woodhead P.J., An in vivo investigation into the suitability of pH dependent polymers for colonic targeting, Int.J. Pharm., 1993, 95, 193-199.
13. Press A.G., Hauptmann I.A., Fuchs B., Ewe K., Ramadore G., Gastrointestinal pH profiles in patients with inflammatory bowel disease, Aliment. Pharmacol. Ther., 1988, 12,673-678.
14. Wilding I.R., Davies S.S., Bakhshaee M., Stevens HN.E., Sparrow R.A., Brennan J., Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation. Pharm. Res., 1992, 9, 654-657.
15. Davis S., Hardy J.G., Taylor M.J., The in-vivo evaluation of an osmotic device using ¥scientigraphy, J.Pharm.Pharmacol., 36, 740-742.
16. Perkins A.C., Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system, Pharm. Res., 1999, 16, 1087-1092.
17. Kramer A., Turk S., Vrecer F., Statistical optimization of diclofenac sodium sustained release pellets coated with polymethacrylic films, Int J Pharm., 2003, 256, 43-52.
18. Hardy J.G., Wilson C.G., Wood E., Drug delivery to the proximal colon, J. Pharmacol., 1985, 37, 874-877.
19. Rodriguez M., Vila-Jato J.L., Torres D., Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region, J Control Rel., 1998, 55, 67-77.
20. Gupta V.K., Beckert T.E., Deusch N.J., Harinaraon M., Price J.C., A novel pH and time based multi potential colonic drug delivery system I. Development, Int. J Pharm., 2001, 213, 83-91.
21. Huyghebaert N., Vermeire A., Remon J.P., In vitro evaluation of coating polymers for enteric coating and human ileal targeting, International Journal of Pharmaceutics., 2005, 298,26-37.
22. Chongmin J.I., Huinan XU., In vitro evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin, Journal of Drug Targeting, February, 2007, 15,(2), 123-131.
23. Rane S., Kale V., Evaluation of modified Guar Gum as film coating material, International Journal of Chem Tech Research, April-June, 2009, 1, 180-182.
24. Liberman A.H., Lachman H., Sphwartz B.J., Pharmaceutical dosage form, Tablets.vol 1. 2nd ed. New York, Maeshal Dekker, 1989, 131-203.
25. Joshi M.R., Misra A.N., Spectrophotometrically determination of budesonide. Indian journal of pharmaceutical science, 2000, 62(2), 92-96.