메뉴 건너뛰기




Volumn 17, Issue 15, 2011, Pages 1436-1442

Restless legs syndrome in children: A review and update on pharmacological options

Author keywords

Augmentation; Dopamine agonist; Ferritin; Genetics; Pediatric; Restless legs syndrome; Rls; Treatment

Indexed keywords

AMANTADINE; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; BROMOCRIPTINE; CABERGOLINE; CARBAMAZEPINE; CLONAZEPAM; CLONIDINE; DIHYDROERGOCRYPTINE; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; GABAPENTIN; GABAPENTIN ENACARBIL; IRON; LEVODOPA; LISURIDE; METHADONE; OPIATE; OXYCODONE; PERGOLIDE; PRAMIPEXOLE; PREGABALIN; ROPINIROLE; ROTIGOTINE; SUMANIROLE; TOPIRAMATE; TRAMADOL; UNINDEXED DRUG; VALPROIC ACID; ZOLPIDEM;

EID: 84856254541     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211796197142     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 70349865294 scopus 로고    scopus 로고
    • Restless legs syndrome
    • Ekbom K, Ulfberg J. Restless legs syndrome. J Intern Med 2009; 266: 419-31.
    • (2009) J Intern Med , vol.266 , pp. 419-431
    • Ekbom, K.1    Ulfberg, J.2
  • 2
    • 2542490412 scopus 로고    scopus 로고
    • Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: The REST (RLS epidemiology, symptoms, and treatment) primary care study
    • Hening W, Walters AS, Allen RP, Montplaisir J, Myers A, Ferini- Strambi L. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 2004; 5: 237-46.
    • (2004) Sleep Med , vol.5 , pp. 237-246
    • Hening, W.1    Walters, A.S.2    Allen, R.P.3    Montplaisir, J.4    Myers, A.5    Ferini-Strambi, L.6
  • 3
    • 0031027378 scopus 로고    scopus 로고
    • Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria
    • Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lesperance P. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord 1997; 12: 61-5
    • (1997) Mov Disord , vol.12 , pp. 61-65
    • Montplaisir, J.1    Boucher, S.2    Poirier, G.3    Lavigne, G.4    Lapierre, O.5    Lesperance, P.6
  • 6
    • 0037738587 scopus 로고    scopus 로고
    • Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health
    • Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health. Sleep Med 2003; 4: 101-19.
    • (2003) Sleep Med , vol.4 , pp. 101-119
    • Allen, R.P.1    Picchietti, D.2    Hening, W.A.3    Trenkwalder, C.4    Walters, A.S.5    Montplaisir, J.6
  • 7
    • 77954958574 scopus 로고    scopus 로고
    • Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment
    • Picchietti MA, Picchietti DL. Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment. Sleep Med 2010; 11: 643-51.
    • (2010) Sleep Med , vol.11 , pp. 643-651
    • Picchietti, M.A.1    Picchietti, D.L.2
  • 8
    • 0001936579 scopus 로고    scopus 로고
    • Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset
    • Allen RP, Earley CJ. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset. Sleep Med 2000; 1: 11-9.
    • (2000) Sleep Med , vol.1 , pp. 11-19
    • Allen, R.P.1    Earley, C.J.2
  • 9
    • 51749084267 scopus 로고    scopus 로고
    • Early manifestations of restless legs syndrome in childhood and adolescence
    • Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Med 2008; 9: 770-81.
    • (2008) Sleep Med , vol.9 , pp. 770-781
    • Picchietti, D.L.1    Stevens, H.E.2
  • 10
    • 77954855475 scopus 로고    scopus 로고
    • Restless legs syndrome: Pathophysiology, clinical presentation and management
    • Trenkwalder C, Paulus W. Restless legs syndrome: pathophysiology, clinical presentation and management. Nat Rev Neurol 2010; 6: 337-46.
    • (2010) Nat Rev Neurol , vol.6 , pp. 337-346
    • Trenkwalder, C.1    Paulus, W.2
  • 11
    • 0028631901 scopus 로고
    • Restless legs syndrome and sleep bruxism: Prevalence and association among Canadians
    • Lavigne GJ, Montplaisir JY. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep 1994; 17: 739-43.
    • (1994) Sleep , vol.17 , pp. 739-743
    • Lavigne, G.J.1    Montplaisir, J.Y.2
  • 13
    • 20144387708 scopus 로고    scopus 로고
    • Restless legs syndrome: Confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity
    • Desautels A, Turecki G, Montplaisir J, et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol 2005; 62: 591-6.
    • (2005) Arch Neurol , vol.62 , pp. 591-596
    • Desautels, A.1    Turecki, G.2    Montplaisir, J.3
  • 14
    • 33244486964 scopus 로고    scopus 로고
    • Evidence for further genetic locus heterogeneity and confirmation of RLS-1 in restless legs syndrome
    • Winkelmann J, Lichtner P, Pütz B, et al. Evidence for further genetic locus heterogeneity and confirmation of RLS-1 in restless legs syndrome. Mov Disord 2006; 21: 28-33.
    • (2006) Mov Disord , vol.21 , pp. 28-33
    • Winkelmann, J.1    Lichtner, P.2    Pütz, B.3
  • 15
    • 2542595563 scopus 로고    scopus 로고
    • The 14q restless legs syndrome locus in the French Canadian population
    • Levchenko A, Montplaisir J, Dubé M, et al. The 14q restless legs syndrome locus in the French Canadian population. Ann Neurol 2004; 55: 887-91.
    • (2004) Ann Neurol , vol.55 , pp. 887-891
    • Levchenko, A.1    Montplaisir, J.2    Dubé, M.3
  • 17
    • 33747037830 scopus 로고    scopus 로고
    • RLS3: Finemapping of an autosomal dominant locus in a family with intrafamilial heterogeneity
    • Liebetanz KM, Winkelmann J, Trenkwalder C, et al. RLS3: finemapping of an autosomal dominant locus in a family with intrafamilial heterogeneity. Neurology 2006; 67: 320-21.
    • (2006) Neurology , vol.67 , pp. 320-321
    • Liebetanz, K.M.1    Winkelmann, J.2    Trenkwalder, C.3
  • 18
    • 40349112722 scopus 로고    scopus 로고
    • Evidence for linkage of restless legs syndrome to chromosome 9p: Are there two distinct loci?
    • Lohmann-Hedrich K, Neumann A, Kleensang A, et al. Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci? Neurology 2008; 70: 686-94.
    • (2008) Neurology , vol.70 , pp. 686-694
    • Lohmann-Hedrich, K.1    Neumann, A.2    Kleensang, A.3
  • 19
    • 33748696387 scopus 로고    scopus 로고
    • A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13
    • Levchenko A, Provost S, Montplaisir JY, et al. A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13. Neurology 2006; 67: 900-01.
    • (2006) Neurology , vol.67 , pp. 900-901
    • Levchenko, A.1    Provost, S.2    Montplaisir, J.Y.3
  • 20
    • 33749005651 scopus 로고    scopus 로고
    • Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate
    • Pichler I, Marroni F, Volpato CB, et al. Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate. Neurology 2006; 79: 716-23.
    • (2006) Neurology , vol.79 , pp. 716-723
    • Pichler, I.1    Marroni, F.2    Volpato, C.B.3
  • 21
    • 61449215329 scopus 로고    scopus 로고
    • Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1
    • Levchenko, A. Autosomal-dominant locus for restless legs syndrome in French-Canadians on chromosome 16p12.1. MovDisord24 (2008): 40-50.
    • (2008) MovDisord24 , pp. 40-50
    • Levchenko, A.1
  • 22
    • 34547497308 scopus 로고    scopus 로고
    • Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    • Winkelmann J, Schormair B, Lichtner P, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet; 2006; 39: 1000-6.
    • (2006) Nat Genet , vol.39 , pp. 1000-1006
    • Winkelmann, J.1    Schormair, B.2    Lichtner, P.3
  • 23
    • 48349142470 scopus 로고    scopus 로고
    • PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
    • Schormair B, Kemlink D, Roeske D, et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet 2008; 40: 946-8.
    • (2008) Nat Genet , vol.40 , pp. 946-948
    • Schormair, B.1    Kemlink, D.2    Roeske, D.3
  • 24
    • 34547926806 scopus 로고    scopus 로고
    • A genetic risk factor for periodic limb movements in sleep
    • Stefansson H, Rye DB, Hicks A, et al. A genetic risk factor for periodic limb movements in sleep. N Engl J Med 2007; 357: 639-47.
    • (2007) N Engl J Med , vol.357 , pp. 639-647
    • Stefansson, H.1    Rye, D.B.2    Hicks, A.3
  • 26
    • 34250861233 scopus 로고    scopus 로고
    • International Restless Legs Syndrome Study Group. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: Report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute
    • García-Borreguero D, Allen RP, Kohnen R, et al.; International Restless Legs Syndrome Study Group. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute. Sleep Med 2007; 8: 520-30.
    • (2007) Sleep Med , vol.8 , pp. 520-530
    • García-Borreguero, D.1    Allen, R.P.2    Kohnen, R.3
  • 29
    • 44849123222 scopus 로고    scopus 로고
    • Restless legs syndrome and periodic limb movement disorder in children and adolescents
    • Picchietti MA, Picchietti DL. Restless legs syndrome and periodic limb movement disorder in children and adolescents. Semin Pediatr Neurol 2008; 15: 91-9.
    • (2008) Semin Pediatr Neurol , vol.15 , pp. 91-99
    • Picchietti, M.A.1    Picchietti, D.L.2
  • 30
    • 60849115293 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome
    • Earley CJ, Horska A, Mohamed MA, Barker PB, Beard JL, Allen RP. A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome. Sleep Med 2009; 10: 206-11.
    • (2009) Sleep Med , vol.10 , pp. 206-211
    • Earley, C.J.1    Horska, A.2    Mohamed, M.A.3    Barker, P.B.4    Beard, J.L.5    Allen, R.P.6
  • 31
    • 69849101384 scopus 로고    scopus 로고
    • A randomized, doubleblind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome
    • Grote L, Leissner L, Hedner J, Ulfberg J. A randomized, doubleblind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome. Mov Disord 2009; 24: 1445-52.
    • (2009) Mov Disord , vol.24 , pp. 1445-1452
    • Grote, L.1    Leissner, L.2    Hedner, J.3    Ulfberg, J.4
  • 32
    • 77954953524 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled multicenter evaluation of restless legs syndrome treatment with 1000 mg of IV iron (ferric carboxymaltose)
    • Allen RP, Butcher A, Du W. Double-blind, placebo-controlled multicenter evaluation of restless legs syndrome treatment with 1000 mg of IV iron (ferric carboxymaltose). Sleep 2009; 32: A294-5.
    • (2009) Sleep , vol.32
    • Allen, R.P.1    Butcher, A.2    Du, W.3
  • 33
    • 0034000833 scopus 로고    scopus 로고
    • A randomized, doubleblind placebo-controlled trial of iron in restless legs syndrome
    • Davis BJ, Rajput A, Rajput ML, Aul EA, Eichhorn GR. A randomized, doubleblind placebo-controlled trial of iron in restless legs syndrome. Eur Neurol 2000; 43: 70-5.
    • (2000) Eur Neurol , vol.43 , pp. 70-75
    • Davis, B.J.1    Rajput, A.2    Rajput, M.L.3    Aul, E.A.4    Eichhorn, G.R.5
  • 34
    • 69949132983 scopus 로고    scopus 로고
    • Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double-blind, placebocontrolled study
    • Wang J, O'Reilly B, Venkataraman R, Mysliwiec V, Mysliwiec A. Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebocontrolled study. Sleep Med 2009; 10: 973-5.
    • (2009) Sleep Med , vol.10 , pp. 973-975
    • Wang, J.1    O'Reilly, B.2    Venkataraman, R.3    Mysliwiec, V.4    Mysliwiec, A.5
  • 35
    • 61449256613 scopus 로고    scopus 로고
    • Treatment of restless legs syndrome: An evidence-based review and implications for clinical practice
    • Trenkwalder C, Hening WA, Montagna P, et al. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Mov Disord 2008; 23: 2267-302.
    • (2008) Mov Disord , vol.23 , pp. 2267-2302
    • Trenkwalder, C.1    Hening, W.A.2    Montagna, P.3
  • 36
  • 37
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/11
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017555s070 lbl.pdf. Accessed 03/11/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 38
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/11
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019856s027 lbl.pdf. Accessed 03/11/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 39
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/14
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020667s014s017s018lbl.pdf. Accessed 03/14/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 40
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/14
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020658s018s020s021lbl.pdf. Accessed 03/14/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 42
    • 61449229152 scopus 로고    scopus 로고
    • Diagnosis and management of restless legs syndrome in children
    • Apr
    • Simakajornboon N, Kheirandish-Gozal L, Gozal D. Diagnosis and management of restless legs syndrome in children. Sleep Med Rev 2009 Apr; 13(2): 149-56.
    • (2009) Sleep Med Rev , vol.13 , Issue.2 , pp. 149-156
    • Simakajornboon, N.1    Kheirandish-Gozal, L.2    Gozal, D.3
  • 43
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/12
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020235s036,020882s022,021129s022lbl.pdf. Accessed 03/12/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 44
    • 77957343163 scopus 로고    scopus 로고
    • The use of gabapentin enacarbil in the treatment of restless legs syndrome
    • Yaltho TC, Ondo WG. The use of gabapentin enacarbil in the treatment of restless legs syndrome. Ther Adv Neurol Disord 2010; 3: 269-75.
    • (2010) Ther Adv Neurol Disord , vol.3 , pp. 269-275
    • Yaltho, T.C.1    Ondo, W.G.2
  • 45
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/10
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021446s021lbl.pdf. Accessed 03/10/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 46
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/15
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022272s006lbl.pdf. Accessed 03/15/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 47
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/15
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017058s019lbl.pdf. Accessed 03/15/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 48
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from:, Accessed 03/15
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022370s000lbl.pdf. Accessed 03/15/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 49
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/12
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/017407s036lbl.pdf. Accessed 03/12/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 50
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/12
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/017533s046s048,020813s006s007lbl.pdf. Accessed 03/12/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)
  • 51
    • 84856282018 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD. Available from, Accessed 03/12
    • US Food and Drug Administration [Home Page for the Food and Drug Administration (FDA)]. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019908s029lbl.pdf. Accessed 03/12/2011.
    • (2011) Home Page for the Food and Drug Administration (FDA)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.