-
1
-
-
43749104249
-
A chemical approach to stem-cell biology and regenerative medicine
-
DOI 10.1038/nature07042, PII NATURE07042
-
Xu Y., Shi Y., Ding S.. A Chemical Approach to Stem-Cell Biology and Regenerative Medicine. Nature. 2008 ; 453: 338-344 (Pubitemid 351693140)
-
(2008)
Nature
, vol.453
, Issue.7193
, pp. 338-344
-
-
Xu, Y.1
Shi, Y.2
Ding, S.3
-
2
-
-
72749089194
-
Small Molecules That Modulate Embryonic Stem Cell Fate and Somatic Cell Reprogramming
-
Li W., Ding S.. Small Molecules That Modulate Embryonic Stem Cell Fate and Somatic Cell Reprogramming. Trends Pharmacol. Sci. 2010 ; 31: 36-45
-
(2010)
Trends Pharmacol. Sci
, vol.31
, pp. 36-45
-
-
Li, W.1
Ding, S.2
-
3
-
-
65449133561
-
Identification of Small-Molecule Modulators of Mouse SVZ Progenitor Cell Proliferation and Differentiation through High-Throughput Screening
-
Liu Y., Lacson R., Cassaday J., Ross D. A., Kreamer A., Hudak E., Peltier R., McLaren D., Muñoz-Sanjuan I., Santini F., et al. Identification of Small-Molecule Modulators of Mouse SVZ Progenitor Cell Proliferation and Differentiation through High-Throughput Screening. J. Biomol. Screen. 2009 ; 14: 319-329
-
(2009)
J. Biomol. Screen
, vol.14
, pp. 319-329
-
-
Liu, Y.1
Lacson, R.2
Cassaday, J.3
Ross, D.A.4
Kreamer, A.5
Hudak, E.6
Peltier, R.7
McLaren, D.8
Muñoz-Sanjuan, I.9
Santini, F.10
-
4
-
-
46949085597
-
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
-
DOI 10.1038/nbt1418, PII NBT1418
-
Huangfu D., Maehr R., Guo W., Eijkelenboom A., Snitow M., Chen A. E., Melton D. A.. Induction of Pluripotent Stem Cells by Defined Factors Is Greatly Improved by Small-Molecule Compounds. Nat. Biotechnol. 2008 ; 26: 795-797 (Pubitemid 351961456)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.7
, pp. 795-797
-
-
Huangfu, D.1
Maehr, R.2
Guo, W.3
Eijkelenboom, A.4
Snitow, M.5
Chen, A.E.6
Melton, D.A.7
-
5
-
-
54949115497
-
Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds
-
Shi Y., Desponts C., Do J. T., Hahm H. S., Schöler H. R., Ding S.. Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds. Cell Stem Cell. 2008 ; 3: 568-574
-
(2008)
Cell Stem Cell
, vol.3
, pp. 568-574
-
-
Shi, Y.1
Desponts, C.2
Do, J.T.3
Hahm, H.S.4
Schöler, H.R.5
Ding, S.6
-
6
-
-
67049158201
-
Reprogramming of Murine Fibroblasts to Induced Pluripotent Stem Cells with Chemical Complementation of Klf4
-
Lyssiotis C. A., Foreman R. K., Staerk J., Garcia M., Mathur D., Markoulaki S., Hanna J., Lairson L. L., Charette B. D., et al. Reprogramming of Murine Fibroblasts to Induced Pluripotent Stem Cells with Chemical Complementation of Klf4. Proc. Natl. Acad. Sci. U. S. A.. 2009 ; 106: 8912-8917
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 8912-8917
-
-
Lyssiotis, C.A.1
Foreman, R.K.2
Staerk, J.3
Garcia, M.4
Mathur, D.5
Markoulaki, S.6
Hanna, J.7
Lairson, L.L.8
Charette, B.D.9
-
7
-
-
34247626853
-
The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARγ Expression
-
DOI 10.1016/j.cmet.2007.03.010, PII S1550413107000733
-
Waki H., Park K. W., Mitro N., Pei L., Damoiseaux R., Wilpitz D. C., Reue K., Saez E., Tontonoz P.. The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARgamma Expression. Cell Metab. 2007 ; 5: 357-370 (Pubitemid 46667757)
-
(2007)
Cell Metabolism
, vol.5
, Issue.5
, pp. 357-370
-
-
Waki, H.1
Park, K.W.2
Mitro, N.3
Pei, L.4
Damoiseaux, R.5
Wilpitz, D.C.6
Reue, K.7
Saez, E.8
Tontonoz, P.9
-
8
-
-
33646414025
-
Orally bioavailable GSK-3α/β dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
-
DOI 10.1359/jbmr.060316
-
Kulkarni N. H., Onyia J. E., Zeng Q., Tian X., Liu M., Halladay D. L., Frolik C. A., Engler T., Wei T., Kriauciunas A.. Orally Bioavailable GSK-3alpha/beta Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo. J. Bone Miner. Res. 2006 ; 21: 910-920 (Pubitemid 43787998)
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.6
, pp. 910-920
-
-
Kulkarni, N.H.1
Onyia, J.E.2
Zeng, Q.3
Tian, X.4
Liu, M.5
Halladay, D.L.6
Frolik, C.A.7
Engler, T.8
Wei, T.9
Kriauciunas, A.10
Martin, T.J.11
Sato, M.12
Bryant, H.U.13
Ma, Y.L.14
-
9
-
-
38849130851
-
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
-
DOI 10.1172/JCI33102
-
Mukherjee S., Raje N., Schoonmaker J. A., Liu J. C., Hideshima T., Wein M. N., Jones D. C., Vallet S., Bouxsein M. L., Pozzi S., et al. Pharmacologic Targeting of a Stem/Progenitor Population In Vivo Is Associated with Enhanced Bone Regeneration in Mice. J. Clin. Invest. 2008 ; 118: 491-504 (Pubitemid 351206540)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.2
, pp. 491-504
-
-
Mukherjee, S.1
Raje, N.2
Schoonmaker, J.A.3
Liu, J.C.4
Hideshima, T.5
Wein, M.N.6
Jones, D.C.7
Vallet, S.8
Bouxsein, M.L.9
Pozzi, S.10
Chhetri, S.11
Seo, Y.D.12
Aronson, J.P.13
Patel, C.14
Fulciniti, M.15
Purton, L.E.16
Glimcher, L.H.17
Lian, J.B.18
Stein, G.19
Anderson, K.C.20
Scadden, D.T.21
more..
-
10
-
-
44349152907
-
High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells
-
DOI 10.1016/j.stem.2008.05.010, PII S1934590908002245
-
Desbordes S. C., Placantonakis D. G., Ciro A., Socci N. D., Lee G., Djaballah H., Studer L.. High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells. Cell Stem Cell. 2008 ; 2: 602-612 (Pubitemid 351729221)
-
(2008)
Cell Stem Cell
, vol.2
, Issue.6
, pp. 602-612
-
-
Desbordes, S.C.1
Placantonakis, D.G.2
Ciro, A.3
Socci, N.D.4
Lee, G.5
Djaballah, H.6
Studer, L.7
-
11
-
-
34248393912
-
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
-
DOI 10.1073/pnas.0701331104
-
Miyabayashi T., Teo J. L., Yamamoto M., McMillan M., Nguyen C., Kahn M.. Wnt/beta-catenin/CBP Signaling Maintains Long-Term Murine Embryonic Stem Cell Pluripotency. Proc. Natl. Acad. Sci. U. S. A.. 2007 ; 104: 5668-5673 (Pubitemid 47175738)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.13
, pp. 5668-5673
-
-
Miyabayashi, T.1
Teo, J.-L.2
Yamamoto, M.3
McMillan, M.4
Nguyen, C.5
Kahn, M.6
-
12
-
-
0037446546
-
Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
-
DOI 10.1161/01.CIR.0000064899.53876.A3
-
Takahashi T., Lord B., Schulze P. C., Fryer R., Sarang S. S., Gullans S. R., Lee R. T.. Ascorbic Acid Enhances Differentiation of Embryonic Stem Cells into Cardiac Myocytes. Circulation. 2003 ; 107: 1912-1916 (Pubitemid 36444134)
-
(2003)
Circulation
, vol.107
, Issue.14
, pp. 1912-1916
-
-
Takahashi, T.1
Lord, B.2
Schulze, P.C.3
Fryer, R.M.4
Sarang, S.S.5
Gullans, S.R.6
Lee, R.T.7
-
13
-
-
62649138086
-
A Small Molecule That Directs Differentiation of Human ESCs into the Pancreatic Lineage
-
Chen S., Borowiak M., Fox J. L., Maehr R., Osafune K., Davidow L., Lam K., Peng L. F., Schreiber S. L., Rubin L. L., et al. A Small Molecule That Directs Differentiation of Human ESCs into the Pancreatic Lineage. Nat. Chem. Biol. 2009 ; 5: 258-265
-
(2009)
Nat. Chem. Biol
, vol.5
, pp. 258-265
-
-
Chen, S.1
Borowiak, M.2
Fox, J.L.3
Maehr, R.4
Osafune, K.5
Davidow, L.6
Lam, K.7
Peng, L.F.8
Schreiber, S.L.9
Rubin, L.L.10
-
14
-
-
65349086683
-
A Small Molecule Primes Embryonic Stem Cells for Differentiation
-
Zhu S., Wurdak H., Wang J., Lyssiotis C. A., Peters E. C., Cho C. Y., Wu X., Schultz P. G.. A Small Molecule Primes Embryonic Stem Cells for Differentiation. Cell Stem Cell. 2009 ; 4: 416-426
-
(2009)
Cell Stem Cell
, vol.4
, pp. 416-426
-
-
Zhu, S.1
Wurdak, H.2
Wang, J.3
Lyssiotis, C.A.4
Peters, E.C.5
Cho, C.Y.6
Wu, X.7
Schultz, P.G.8
-
15
-
-
47749109128
-
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation
-
DOI 10.1073/pnas.0710413105
-
Hahn C. K., Ross K. N., Warrington I. M., Mazitschek R., Kanegai C. M., Wright R. D., Kung A. L., Golub T. R., Stegmaier K.. Expression-Based Screening Identifies the Combination of Histone Deacetylase Inhibitors and Retinoids for Neuroblastoma Differentiation. Proc. Natl. Acad. Sci. U. S. A.. 2008 ; 105: 9751-9756 (Pubitemid 352031372)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.28
, pp. 9751-9756
-
-
Hahn, C.K.1
Ross, K.N.2
Warrington, I.M.3
Mazitschek, R.4
Kanegai, C.M.5
Wright, R.D.6
Kung, A.L.7
Golub, T.R.8
Stegmaier, K.9
-
16
-
-
1442335997
-
Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation
-
DOI 10.1038/ng1305
-
Stegmaier K., Ross K. N., Colavito S. A., O'Malley S., Stockwell B. R., Golub T. R.. Gene Expression-Based High-Throughput Screening(GE-HTS) and Application to Leukemia Differentiation. Nat. Genet. 2004 ; 36: 257-263 (Pubitemid 38282750)
-
(2004)
Nature Genetics
, vol.36
, Issue.3
, pp. 257-263
-
-
Stegmaier, K.1
Ross, K.N.2
Colavito, S.A.3
O'Malley, S.4
Stockwell, B.R.5
Golub, T.R.6
-
17
-
-
34247217907
-
Chemical genetics reveals a complex functional ground state of neural stem cells
-
DOI 10.1038/nchembio873, PII NCHEMBIO873
-
Diamandis P., Wildenhain J., Clarke I. D., Sacher A. G., Graham J., Bellows D. S., Ling E. K., Ward R. J., Jamieson L. G., Tyers M., et al. Chemical Genetics Reveals a Complex Functional Ground State of Neural Stem Cells. Nat. Chem. Biol. 2007 ; 3: 268-273 (Pubitemid 46625832)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.5
, pp. 268-273
-
-
Diamandis, P.1
Wildenhain, J.2
Clarke, I.D.3
Sacher, A.G.4
Graham, J.5
Bellows, D.S.6
Ling, E.K.M.7
Ward, R.J.8
Jamieson, L.G.9
Tyers, M.10
Dirks, P.B.11
-
18
-
-
0028641559
-
Stimulation of Adipogenesis in Fibroblasts by PPAR gamma 2, a Lipid-Activated Transcription Factor
-
Tontonoz P., Hu E., Spiegelman B. M.. Stimulation of Adipogenesis in Fibroblasts by PPAR gamma 2, a Lipid-Activated Transcription Factor. Cell. 1994 ; 79: 1147-1156
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
19
-
-
2342424743
-
Development of definitive endoderm from embryonic stem cells in culture
-
DOI 10.1242/dev.01044
-
Kubo A., Shinozaki K., Shannon J. M., Kouskoff V., Kennedy M., Woo S., Fehling H. J., Keller G.. Development of Definitive Endoderm from Embryonic Stem Cells in Culture. Development. 2004 ; 131: 1651-1662 (Pubitemid 38559291)
-
(2004)
Development
, vol.131
, Issue.7
, pp. 1651-1662
-
-
Kubo, A.1
Shinozaki, K.2
Shannon, J.M.3
Kouskoff, V.4
Kennedy, M.5
Woo, S.6
Fehling, H.J.7
Keller, G.8
-
20
-
-
28644448149
-
Efficient differentiation of human embryonic stem cells to definitive endoderm
-
DOI 10.1038/nbt1163
-
D'Amour K. A., Agulnick A. D., Eliazer S., Kelly O. G., Kroon E., Baetge E. E.. Efficient Differentiation of Human Embryonic Stem Cells to Definitive Endoderm. Nat. Biotechnol. 2005 ; 23: 1534-1541 (Pubitemid 41752931)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.12
, pp. 1534-1541
-
-
D'Amour, K.A.1
Agulnick, A.D.2
Eliazer, S.3
Kelly, O.G.4
Kroon, E.5
Baetge, E.E.6
-
21
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
DOI 10.1038/nm979
-
Sato N., Meijer L., Skaltsounis L., Greengard P., Brivanlou A. H.. Maintenance of Pluripotency in Human and Mouse Embryonic Stem Cells through Activation of Wnt Signaling by a Pharmacological GSK-3-Specific Inhibitor. Nat. Med. 2004 ; 10: 55-63 (Pubitemid 38524699)
-
(2004)
Nature Medicine
, vol.10
, Issue.1
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
22
-
-
44949240499
-
Chemicals that modulate stem cell differentiation
-
DOI 10.1073/pnas.0802825105
-
Hwang K. C., Kim J. Y., Chang W., Kim D. S., Lim S., Kang S. M., Song B. W., Ha H. Y., Huh Y. J., Choi I. G., et al. Chemicals That Modulate Stem Cell Differentiation. Proc. Natl. Acad. Sci. U. S. A.. 2008 ; 105: 7467-7471 (Pubitemid 351830041)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.21
, pp. 7467-7471
-
-
Hwang, K.-C.1
Kim, J.Y.2
Chang, W.3
Kim, D.-S.4
Lim, S.5
Kang, S.-M.6
Song, B.-W.7
Ha, H.-Y.8
Huh, Y.J.9
Choi, I.-G.10
Hwang, D.-Y.11
Song, H.12
Jang, Y.13
Chung, N.14
Kim, S.-H.15
Kim, D.-W.16
-
23
-
-
0034737742
-
Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
-
DOI 10.1074/jbc.275.13.9645
-
Jaiswal R. K., Jaiswal N., Bruder S. P., Mbalaviele G., Marshak D. R., Pittenger M. F.. Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-Activated Protein Kinase. J. Biol. Chem. 2000 ; 275: 9645-9652 (Pubitemid 30185197)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.13
, pp. 9645-9652
-
-
Jaiswal, R.K.1
Jaiswal, N.2
Bruder, S.P.3
Mbalaviele, G.4
Marshak, D.R.5
Pittenger, M.F.6
-
24
-
-
33745128352
-
Dexamethasone facilitates erythropoiesis in murine embryonic stem cells differentiating into hematopoietic cells in vitro
-
DOI 10.1016/j.bbrc.2006.05.130, PII S0006291X06012071
-
Srivastava A. S., Kaushal S., Mishra R., Lane T. A., Carrier E.. Dexamethasone Facilitates Erythropoiesis in Murine Embryonic Stem Cells Differentiating into Hematopoietic Cells In Vitro. Biochem. Biophys. Res. Commun. 2006 ; 346: 508-516 (Pubitemid 43902713)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.346
, Issue.2
, pp. 508-516
-
-
Srivastava, A.S.1
Kaushal, S.2
Mishra, R.3
Lane, T.A.4
Carrier, E.5
-
25
-
-
34347221578
-
Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines
-
DOI 10.1038/nprot.2007.18, PII NPROT.2007.18
-
Soto-Gutierrez A., Navarro-Alvarez N., Zhao D., Rivas-Carrillo J. D., Lebkowski J., Tanaka N., Fox I. J., Kobayashi N.. Differentiation of Mouse Embryonic Stem Cells to Hepatocyte-Like Cells by Co-culture with Human Liver Nonparenchymal Cell Lines. Nat. Protoc. 2007 ; 2: 347-356 (Pubitemid 47040050)
-
(2007)
Nature Protocols
, vol.2
, Issue.2
, pp. 347-356
-
-
Soto-Gutierrez, A.1
Navarro-Alvarez, N.2
Zhao, D.3
Rivas-Carrillo, J.D.4
Lebkowski, J.5
Tanaka, N.6
Fox, I.J.7
Kobayashi, N.8
-
26
-
-
14644400268
-
Chondrogenic differentiation of murine embryonic stem cells: Effects of culture conditions and dexamethasone
-
DOI 10.1002/jcb.20171
-
Tanaka H., Murphy C. L., Murphy C., Kimura M., Kawai S., Polak J. M.. Chondrogenic Differentiation of Murine Embryonic Stem Cells: Effects of Culture Conditions and Dexamethasone. J. Cell Biochem. 2004 ; 93: 454-462 (Pubitemid 44264181)
-
(2004)
Journal of Cellular Biochemistry
, vol.93
, Issue.3
, pp. 454-462
-
-
Tanaka, H.1
Murphy, C.L.2
Murphy, C.3
Kimura, M.4
Kawai, S.5
Polak, J.M.6
-
27
-
-
0031012411
-
Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
-
DOI 10.1002/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I
-
Jaiswal N., Haynesworth S. E., Caplan A. I., Bruder S. P.. Osteogenic Differentiation of Purified, Culture-Expanded Human Mesenchymal Stem Cells In Vitro. J. Cell Biochem. 1997 ; 64: 295-312 (Pubitemid 27065443)
-
(1997)
Journal of Cellular Biochemistry
, vol.64
, Issue.2
, pp. 295-312
-
-
Jaiswal, N.1
Haynesworth, S.E.2
Caplan, A.I.3
Bruder, S.P.4
-
28
-
-
58049211656
-
Bromodeoxyuridine Induces Senescence in Neural Stem and Progenitor Cells
-
Ross H. H., Levkoff L. H., Marshall G. P., Caldeira M., Steindler D. A., Reynolds B. A., Laywell E. D.. Bromodeoxyuridine Induces Senescence in Neural Stem and Progenitor Cells. Stem Cells. 2008 ; 26: 3218-3227
-
(2008)
Stem Cells
, vol.26
, pp. 3218-3227
-
-
Ross, H.H.1
Levkoff, L.H.2
Marshall, G.P.3
Caldeira, M.4
Steindler, D.A.5
Reynolds, B.A.6
Laywell, E.D.7
-
29
-
-
34250206996
-
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
-
DOI 10.1038/nbt1310, PII NBT1310
-
Watanabe K., Ueno M., Kamiya D., Nishiyama A., Matsumura M., Wataya T., Takahashi J. B., Nishikawa S., Nishikawa S., Muguruma K., et al. A ROCK Inhibitor Permits Survival of Dissociated Human Embryonic Stem Cells. Nat. Biotechnol. 2007 ; 25: 681-686 (Pubitemid 46897207)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.6
, pp. 681-686
-
-
Watanabe, K.1
Ueno, M.2
Kamiya, D.3
Nishiyama, A.4
Matsumura, M.5
Wataya, T.6
Takahashi, J.B.7
Nishikawa, S.8
Nishikawa, S.-I.9
Muguruma, K.10
Sasai, Y.11
|