Are snoRNAs and snoRNA host genes new players in cancer?

Nature Reviews Cancer

Volumn 12, Issue 2, 2012, Pages 84-88

  Williams, Gwyn T ^a   Farzaneh, Farzin ^b  

^a KEELE UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5' TERMINAL OLIGOPYRIMIDINE RNA; C D BOX SMALL NUCLEOLAR RNA; DYSKERIN; GAS5 PROTEIN; H ACA BOX SMALL NUCLEOLAR RNA; MICRORNA; PROTEIN; SMALL NUCLEOLAR RNA; SNORA42 PROTEIN; TELOMERASE CAJAL BODY PROTEIN 1; UNCLASSIFIED DRUG; ZFAS1 PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL FUNCTION; CELL SURVIVAL; DYSKERATOSIS CONGENITA; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; LARGE CELL LYMPHOMA; LUNG NON SMALL CELL CANCER; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RNA PROCESSING; RNA TRANSCRIPTION; RNA TRANSPORT; TRANSCRIPTION REGULATION;

ANIMALS; HUMANS; NEOPLASMS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, SMALL NUCLEOLAR;

EID: 84856236025     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3195     Document Type: Article

References (60)

1. Lestrade, L. & Weber, M. J. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Res. 34, D158-D162 (2006).
2. Kiss-Laszlo, Z., Henry, Y., Bachellerie, J., Caizergues-Ferrer, M. & Kiss, T. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85, 1077-1088 (1996). (Pubitemid 26231174)
3. Tollervey, D. & Kiss, T. Function and synthesis of small nucleolar RNAs. Curr. Opin. Cell Biol. 9, 337-342 (1997). (Pubitemid 27263174)
4. Weinstein L. B., Steitz J. A. Guided tours: from precursor snoRNA to functional snoRNP. Curr. Opin. Cell Biol. 11, 378-384 (1999). (Pubitemid 29273810)
5. Mattick, J. & Makunin, I. Non-coding RNA. Hum. Mol. Genet. 15, R17-R29 (2006).
6. Decatur, W. & Fournier, M. rRNA modifications and ribosome function. Trends Biochem. Sci. 27, 344-351 (2002). (Pubitemid 34756517)
7. Tycowski K. T., Shu M., Kukoyi A., Steitz J. A. A conserved WD40 protein binds the cajal body localization signal of scaRNP particles. Mol. Cell 34, 47-57 (2009).
8. Tycowski, K. T., Shu, M. D. & Steitz, J. A. A mammalian gene with introns instead of exons generating stable RNA products. Nature 379, 464-466 (1996). (Pubitemid 26039529)
9. Smith, C. M. & Steitz, J. A. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5 '-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol. Cell. Biol. 18, 6897-6909 (1998). (Pubitemid 28533011)
10. Dieci, G., Preti, M. & Montanini, B. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. Genomics 94, 83-88 (2009).
11. Hoeppner, M. P., White, S., Jeffares, D. C. & Poole, A. M. Evolutionarily stable association of intronic snornas and micrornas with their host genes. Genome Biol. Evol. 1, 420-428 (2009).
12. Kino, T., Hurt, D. E., Ichijo, T., Nader, N. & Chrousos, G. P. Noncoding RNA Gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor. Sci. Signal. 3, ra8 (2010).
13. Askarian-Amiri, M. E. et al. SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA 17, 878-891 (2011).
14. Williams, G. T. et al. Isolation of genes controlling apoptosis through their effects on cell survival. Gene Ther. Mol. Biol. 10B, 255-261 (2006). (Pubitemid 351976169)
15. Mourtada-Maarabouni, M., Hedge, V. L., Kirkham, L., Farzaneh, F. & Williams, G. T. Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5) J. Cell Sci. 121, 939-946 (2008). (Pubitemid 351639413)
16. Mourtada-Maarabouni, M., Pickard, M. R., Hedge, V. L., Farzaneh, F. & Williams, G. T. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28, 195-208 (2009).
17. Dong, X. et al. Implication of snoRNA U50 in human breast cancer. J. Genet. Genomics 36, 447-454 (2009).
18. Dong, X. et al. SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum. Mol. Genet. 17, 1031-1042 (2008). (Pubitemid 351426037)
19. Gee, H. E. et al. The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br. J. Cancer 104, 1168-1177 (2011).
20. Liao, J. et al. Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol. Cancer 9, 198 (2010).
21. Martens-Uzunova, E. S. et al. Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer. Oncogene 18 Jul 2011 (doi:10.1038/onc.2011.304).
22. Scott, M. S. & Ono, M. From snoRNA to miRNA: dual function regulatory non-coding RNAs. Biochimie 93, 1987-1992 (2011).
23. Kishore, S. & Stamm, S. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311, 230-232 (2006). (Pubitemid 43108188)
24. Sahoo, T. et al. Prader-Willi phenotype caused by paternal deficiency for the HBII-85C/D box small nucleolar RNA cluster. Nature Genet. 40, 719-721 (2008). (Pubitemid 351748873)
25. Kishore, S. et al. The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum. Mol. Genet. 19, 1153-1164 (2010).
26. Tanaka, R. et al. Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6) (q27;q15) of human B-cell lymphoma. Genes Cells 5, 277-287 (2000). (Pubitemid 30253178)
27. Mei, Y.-P. et al. Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene 10 Oct 2011 (doi:10.1038/onc.2011.449).
28. Testa, J. et al. Advances in the analysis of chromosome alterations in human lung carcinomas. Cancer Genet. Cytogenet. 95, 20-32 (1997). (Pubitemid 27188444)
29. Michel, C. I. et al. Small Nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab. 14, 33-44 (2011).
30. Montanaro, L. Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer. J. Pathol. 222, 345-349 (2010).
31. Batista, L. F. Z. et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 474, 399-402 (2011).
32. Hirose, T. & Steitz, J. Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells. Proc. Natl Acad. Sci. USA 98, 12914-12919 (2001). (Pubitemid 33051294)
33. Meyuhas, O. Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267, 6321-6330 (2000).
34. Yamashita, A. et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 23, 1091-1105 (2009).
35. Schneider, C., King, R. M. & Philipson, L. Genes specifically expressed at growth arrest of mammalian-cells. Cell 54, 787-793 (1988).
36. Mourtada-Maarabouni, M., Hasan, A. M., Farzaneh, F. & Williams, G. T. Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5). Mol. Pharmacol. 78, 19-28 (2010).
37. Williams, G. T., Mourtada-Maarabouni, M. & Farzaneh, F. A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes. Biochem. Soc. Trans. 39, 482-486 (2011).
38. Meyuhas, O. & Dreazen, A. Ribosomal protein S6 kinase: from TOP mRNAs to cell size. Prog. Mol. Biol. Transl. Sci. 90, 109-153 (2009).
39. Loreni, F., Iadevaia, V., Tino, E., Caldarola, S. & Amaldi, F. RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis. FEBS Lett. 579, 5517-5520 (2005). (Pubitemid 41455624)
40. Chitpatima, S., Makrides, S., Bandyopadhyay, R. & Brawerman, G. Nucleotide-sequence of a major messenger-RNA for a 21 kilodalton polypeptide that is under translational control in mouse-tumor cells. Nucleic Acids Res. 16, 2350-2350 (1988).
41. Michiels, L., Vanderrauwelaert, E., Vanhasselt, F., Kas, K. & Merregaert, J. Fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the finkel-biskis-reilly murine sarcoma-virus. Oncogene 8, 2537-2546 (1993). (Pubitemid 23252384)
42. Mourtada-Maarabouni, M., Kirkham, L., Farzaneh, F. & Williams, G. T. Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis. J. Leukoc. Biol. 78, 503-514 (2005). (Pubitemid 41061322)
43. Mourtada-Maarabouni, M., Kirkham, L., Farzaneh, F. & Williams, G. T. Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression. Oncogene 23, 9419-9426 (2004). (Pubitemid 40069674)
44. Telerman, A. & Amson, R. The molecular programme of tumour reversion: the steps beyond malignant transformation. Nature Rev. Cancer 9, 206-215 (2009).
45. Dean, J. L. E., Sully, G., Clark, A. R. & Saklatvala, J. The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell. Signal. 16, 1113-1121 (2004). (Pubitemid 38900514)
46. Kakegawa, T. et al. Identification of AUF1 as a rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs. Arch. Biochem. Biophys. 465, 274-281 (2007). (Pubitemid 47283998)
47. Schultze, F. C., Petrova, D. T., Oellerich, M., Armstrong, V. W. & Asif, A. R. Differential proteome and phosphoproteome signatures in human T-lymphoblast cells induced by sirolimus. Cell Prolif. 43, 396-404 (2010).
48. Shchors, K. et al. Cell death inhibiting RNA (CDIR) derived from a 3 '-untranslated region binds AUF1 and heat shock protein 27. J. Biol. Chem. 277, 47061-47072 (2002). (Pubitemid 36159214)
49. Ender, C. et al. A human snoRNA with microRNA-like functions. Mol. Cell 32, 519-528 (2008).
50. Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J. Human miRNA precursors with box H/ACA snoRNA features. PLoS Comput. Biol. 5, e1000507 (2009).
51. Ono, M. et al. Identification of human miRNA precursors that resemble box C/D snoRNAs. Nucleic Acids Res. 39, 3879-3891 (2011).
52. Esquela-Kerscher, A. & Slack, F. Oncomirs-microRNAs with a role in cancer. Nature Rev. Cancer 6, 259-269 (2006).
53. Brameier, M., Herwig, A., Reinhardt, R., Walter, L. & Gruber, J. Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs. Nucleic Acids Res. 39, 675-686 (2011).
54. Xiao, J., Lin, H., Luo, X., Luo, X. & Wang, Z. miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J. 30, 524-532 (2011).
55. Montanaro, L., Trere, D. & Derenzini, M. Nucleolus, ribosomes, and cancer. Am. J. Pathol. 173, 301-310 (2008).
56. Shiue, C.-N., Berkson, R. G. & Wright, A. P. H. c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells. Oncogene 28, 1833-1842 (2009).
57. Novina, C. D. & Chabner, B. A. RNA-directed therapy: the next step in the miRNA revolution. Oncologist 13, 1-3 (2008). (Pubitemid 351206690)
58. Liu, X., Song, W., Sun, T., Zhang, P. & Wang, J. Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles. Mol. Pharm. 8, 250-259 (2011).
59. Doniger, T., Michaeli, S. & Unger, R. Families of H/ACA ncRNA molecules in trypanosomatids. RNA Biol. 6, 370-374 (2009).
60. Liang, X., Liu, Q., Liu, Q., King, T. H. & Fournier, M. J. Strong dependence between functional domains in a dual-function snoRNA infers coupling of rRNA processing and modification events. Nucleic Acids Res. 38, 3376-3387 (2010).