High platelet reactivity to multiple agonists during aspirin and clopidogrel treatment is indicative of a global hyperreactive platelet phenotype

Heart

Volumn 98, Issue 4, 2012, Pages 343-

  Jeong, Young Hoon ^a,b   Park, Yongwhi ^b   Bliden, Kevin P ^a   Tantry, Udaya S ^a   Gurbel, Paul A ^a  

^a SINAI CENTER FOR THROMBOSIS RESEARCH   (United States)

^b Gyeongsang National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CLOPIDOGREL; CYCLOOXYGENASE 2; THROMBOXANE A2;

BLOOD ANALYSIS; BLOOD SAMPLING; DRUG EFFECT; FUNCTION TEST; HEART MUSCLE ISCHEMIA; HUMAN; INTERMETHOD COMPARISON; LETTER; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RELIABILITY; RISK ASSESSMENT; RISK FACTOR; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ASPIRIN; ATHEROSCLEROSIS; FEMALE; HUMANS; MALE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; THROMBOSIS; TICLOPIDINE;

EID: 84856231968     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2011-301129     Document Type: Letter

References (4)

1. Breet NJ, van Werkum JW, Bouman HJ, et al. High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention. Heart 2011;97:983-90.
2. Dichiara J, Bliden KP, Tantry US, et al. Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients. Platelets 2007;18:414-23. (Pubitemid 47347051)
3. Bonello L, Tantry US, Marcucci R, et al; Working Group on High On-Treatment Platelet Reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010;56:919-33.
4. Gurbel PA, Bliden KP, DiChiara J, et al. Evaluation of dose-related effects of aspirin on platelet function: results from the ASpirin-induced Platelet EffeCT (ASPECT) study. Circulation 2007;115:3156-6.